miRNA-based biomarkers, therapies, and resistance in Cancer

Abstract

MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in size, play important roles in gene regulation, and their dysregulation is implicated in human diseases including cancer. A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor immune, and function with miRNA sponges. During the last two decades, the connection between miRNAs and various cancers has been widely researched. Based on evidence about miRNA, numerous potential cancer biomarkers for the diagnosis and prognosis have been put forward, providing a new perspective on cancer screening. Besides, there are several miRNA-based therapies among different cancers being conducted, advanced treatments such as the combination of synergistic strategies and the use of complementary miRNAs provide significant clinical benefits to cancer patients potentially. Furthermore, it is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis. With the belief that studies about miRNAs in human cancer would have great clinical implications, we attempt to summarize the current situation and potential development prospects in this review.

References 227

1. 1.

   Metazoan MicroRNAs. Cell. 2018;173:20-51.

   Not in our library10.1016/j.cell.2018.03.006

2. 2.

   Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell. 1993;75:855-62.

   Not in our library10.1016/0092-8674(93)90530-4

3. 3.
   miRBase: from microRNA sequences to function · 2018

   No notice
4. 4.

   Most mammalian mRNAs are conserved targets of microRNAs. Genome research. 2009;19:92-105.

   Not in our library10.1101/gr.082701.108

5. 5.

   Recent advances on nanomaterials-based fluorimetric approaches for microRNAs detection. Materials science & engineering C, Materials for biological applications. 2019;104:110007.

   Not in our library10.1016/j.msec.2019.110007

6. 6.
   Genenames.org: the HGNC and VGNC resources in 2019 · 2018

   No notice
7. 7.

   A guide to naming human non-coding RNA genes. EMBO J. 2020;39:e103777-e.

   Not in our library10.15252/embj.2019103777

8. 8.

   MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 2004;23:4051-60.

   Not in our library10.1038/sj.emboj.7600385

9. 9.

   Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA (New York, NY). 2004;10:1957-66.

   Not in our library10.1261/rna.7135204

10. 10.

    Functional Anatomy of the Human Microprocessor. Cell. 2015;161:1374-87.

    Not in our library10.1016/j.cell.2015.05.010

11. 11.

    The nuclear RNase III Drosha initiates microRNA processing. Nature. 2003;425:415-9.

    Not in our library10.1038/nature01957

12. 12.

    Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA (New York, NY). 2004;10:185-91.

    Not in our library10.1261/rna.5167604

13. 13.

    Dicer recognizes the 5' end of RNA for efficient and accurate processing. Nature. 2011;475:201-5.

    Not in our library10.1038/nature10198

14. 14.

    Single processing center models for human Dicer and bacterial RNase III. Cell. 2004;118:57-68.

    Not in our library10.1016/j.cell.2004.06.017

15. 15.

    Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis. Mol Cell. 2015;57:397-407.

    Not in our library10.1016/j.molcel.2014.11.030

16. 16.

    The N domain of Argonaute drives duplex unwinding during RISC assembly. Nat Struct Mol Biol. 2012;19:145-51.

    Not in our library10.1038/nsmb.2232

17. 17.

    Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes. Proceedings of the National Academy of Sciences of the United States of America. 2011;108:9208-13.

    Not in our library10.1073/pnas.1018023108

18. 18.

    Re-evaluation of the roles of DROSHA, Export in 5, and DICER in microRNA biogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2016;113:E1881-9.

    Not in our library10.1073/pnas.1602532113

19. 19.

    Intronic microRNA precursors that bypass Drosha processing. Nature. 2007;448:83-6.

    Not in our library10.1038/nature05983

20. 20.

    Analysis of Nearly One Thousand Mammalian Mirtrons Reveals Novel Features of Dicer Substrates. PLoS Comput Biol. 2015;11:e1004441.

    Not in our library10.1371/journal.pcbi.1004441

21. 21.

    A human snoRNA with microRNA-like functions. Mol Cell. 2008;32:519-28.

    Not in our library10.1016/j.molcel.2008.10.017

22. 22.

    Human tRNA-derived small RNAs in the global regulation of RNA silencing. RNA (New York, NY). 2010;16:673-95.

    Not in our library10.1261/rna.2000810

23. 23.

    Regulation of microRNA biogenesis and its crosstalk with other cellular pathways. Nat Rev Mol Cell Biol. 2019;20:5-20.

    Not in our library10.1038/s41580-019-0106-6

24. 24.

    Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage. The Journal of cell biology. 2017;216:2373-89.

    Not in our library10.1083/jcb.201612131

25. 25.

    Tyrosine kinase c-Abl couples RNA polymerase II transcription to DNA double-strand breaks. Nucleic acids research. 2019;47:3467-84.

    Not in our library10.1093/nar/gkz024

26. 26.

    A transfer-RNA-derived small RNA regulates ribosome biogenesis. Nature. 2017;552:57-62.

    Not in our library10.1038/nature25005

27. 27.

    A tRNA-Derived Small RNA Regulates Ribosomal Protein S28 Protein Levels after Translation Initiation in Humans and Mice. Cell reports. 2019;29:3816-24.e4.

    Not in our library10.1016/j.celrep.2019.11.062

28. 28.

    Mammalian 5'-capped microRNA precursors that generate a single microRNA. Cell. 2013;155:1568-80.

    Not in our library10.1016/j.cell.2013.11.027

29. 29.

    A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science. 2010;328:1694-8.

    Not in our library10.1126/science.1190809

30. 30.

    A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature. 2010;465:584-9.

    Not in our library10.1038/nature09092

31. 31.

    Poly(A)-specific ribonuclease mediates 3'-end trimming of Argonaute2-cleaved precursor microRNAs. Cell reports. 2013;5:715-26.

    Not in our library10.1016/j.celrep.2013.09.029

32. 32.

    Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression. Cell. 2007;131:1097-108.

    Not in our library10.1016/j.cell.2007.10.032

33. 33.

    Regulation of miRNA Biogenesis and Histone Modification by K63-Polyubiquitinated DDX17 Controls Cancer Stem-like Features. Cancer Res. 2019;79:2549-63.

    Not in our library10.1158/0008-5472.can-18-2376

34. 34.

    Target-dependent biogenesis of cognate microRNAs in human cells. Nat Commun. 2016;7:12200.

    Not in our library10.1038/ncomms12200

35. 35.

    A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis. Mol Cell. 2017;66:270-84.e13.

    Not in our library10.1016/j.molcel.2017.03.014

36. 36.

    NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing. Nat Struct Mol Biol. 2017;24:816-24.

    Not in our library10.1038/nsmb.3455

37. 37.

    Regulation of pri-miRNA processing by a long noncoding RNA transcribed from an ultraconserved region. Mol Cell. 2014;55:138-47.

    Not in our library10.1016/j.molcel.2014.05.005

38. 38.

    Making RISC. Trends Biochem Sci. 2010;35:368-76.

    Not in our library10.1016/j.tibs.2010.03.009

39. 39.

    Regulation of microRNA function in animals. Nat Rev Mol Cell Biol. 2019;20:21-37.

    Not in our library10.1038/s41580-018-0045-7

40. 40.

    MicroRNAs: target recognition and regulatory functions. Cell. 2009;136:215-33.

    Not in our library10.1016/j.cell.2009.01.002

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