No retraction, correction or concern found when last checked on Oct 17, 2026.
miRNA-based biomarkers, therapies, and resistance in Cancer
Boxue He, Zhenyu Zhao, Qidong Cai and 8 more
International Journal of Biological Sciences · 2020 · Review
Abstract
MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in size, play important roles in gene regulation, and their dysregulation is implicated in human diseases including cancer. A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor immune, and function with miRNA sponges. During the last two decades, the connection between miRNAs and various cancers has been widely researched. Based on evidence about miRNA, numerous potential cancer biomarkers for the diagnosis and prognosis have been put forward, providing a new perspective on cancer screening. Besides, there are several miRNA-based therapies among different cancers being conducted, advanced treatments such as the combination of synergistic strategies and the use of complementary miRNAs provide significant clinical benefits to cancer patients potentially. Furthermore, it is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis. With the belief that studies about miRNAs in human cancer would have great clinical implications, we attempt to summarize the current situation and potential development prospects in this review.
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Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models. Cancer Lett. 2019;442:82-90.
Not in our library10.1016/j.canlet.2018.10.038
- 151.
Therapeutic Potential of LNP-Mediated Delivery of miR-634 for Cancer Therapy. Mol Ther Nucleic Acids. 2020;19:330-8.
Not in our library10.1016/j.omtn.2019.10.045
- 152.
miR-149 inhibits cell proliferation and enhances chemosensitivity by targeting CDC42 and BCL2 in neuroblastoma. Cancer Cell Int. 2019;19:357.
Not in our library10.1186/s12935-019-1082-9
- 153.
MicroRNA-137 inhibits autophagy and chemosensitizes pancreatic cancer cells by targeting ATG5. The international journal of biochemistry & cell biology. 2019;111:63-71.
Not in our library10.1016/j.biocel.2019.01.020
- 154.
Roles of MicroRNA-34a in Epithelial to Mesenchymal Transition, Competing Endogenous RNA Sponging and Its Therapeutic Potential. Int J Mol Sci. 2019;20(4):861.
Not in our library10.3390/ijms20040861
- 155.
- 156.
Up- regulation of miR-328-3p sensitizes non-small cell lung cancer to radiotherapy. Scientific reports. 2016;6:31651.
Not in our library10.1038/srep31651
- 157.
Enhancing adoptive T cell immunotherapy with microRNA therapeutics. Semin Immunol. 2016;28:45-53.
Not in our library10.1016/j.smim.2015.11.006
- 158.
miR-143 Regulates Memory T Cell Differentiation by Reprogramming T Cell Metabolism. J Immunol. 2018;201:2165-75.
Not in our library10.4049/jimmunol.1800230
- 159.
Expression of miR-17-92 enhances anti-tumor activity of T-cells transduced with the anti-EGFRvIII chimeric antigen receptor in mice bearing human GBM xenografts. J Immunother Cancer. 2013;1:21.
Not in our library10.1186/2051-1426-1-21
- 160.
Frequent methylation of the tumour suppressor miR-1258 targeting PDL1: implication in multiple myeloma-specific cytotoxicity and prognostification. Br J Haematol. 2020.
Not in our library10.1111/bjh.16517
- 161.
Simultaneous overexpression of miR-126 and miR-34a induces a superior antitumor efficacy in pancreatic adenocarcinoma. Onco Targets Ther. 2017;10:5591-604.
Not in our library10.2147/ott.s149632
- 162.
Noncoding RNAs: 'our turn' to join the p53 network. J Mol Cell Biol. 2014;6:179-80.
Not in our library10.1093/jmcb/mju022
- 163.
The RNA-binding protein SART3 promotes miR-34a biogenesis and G1 cell cycle arrest in lung cancer cells. J Biol Chem. 2019;294:17188-96.
Not in our library10.1074/jbc.ac119.010419
- 164.
A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer. Oncogene. 2015;34:3547-55.
Not in our library10.1038/onc.2014.282
- 165.
- 166.
MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance. Theranostics. 2018;8:1106-20.
Not in our library10.7150/thno.19904
- 167.
Identification and validation of microRNAs that synergize with miR-34a - a basis for combinatorial microRNA therapeutics. Cell Cycle. 2019;18:1798-811.
Not in our library10.1080/15384101.2019.1634956
- 168.
- 169.
Clinical and biological impact of miR-18a expression in breast cancer after neoadjuvant chemotherapy. Cellular oncology (Dordrecht). 2019;42(5):627-644.
Not in our library10.1007/s13402-019-00450-2
- 170.
Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer. Oncogene. 2019;38(28):5700-5724.
Not in our library10.1038/s41388-019-0823-5
- 171.
Dual Epigenetic Regulation of ERalpha36 Expression in Breast Cancer Cells. Int J Mol Sci. 2019;20(11):2637.
Not in our library10.3390/ijms20112637
- 172.
Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancer. Oncogene. 2013;32:1173-82.
Not in our library10.1038/onc.2012.128
- 173.
A Fast Parameter Identification Framework for Personalized Pharmacokinetics. Scientific reports. 2019;9:14143.
Not in our library10.1038/s41598-019-50810-z
- 174.
Deregulation of the Genes that Are Involved in Drug Absorption, Distribution, Metabolism, and Excretion in Hepatocellular Carcinoma. The Journal of pharmacology and experimental therapeutics. 2019;368:363-81.
Not in our library10.1124/jpet.118.255018
- 175.
Current knowledge of microRNA-mediated regulation of drug metabolism in humans. Expert opinion on drug metabolism & toxicology. 2018;14:493-504.
Not in our library10.1080/17425255.2018.1472237
- 176.
Bioengineered miR-27b-3p and miR-328-3p modulate drug metabolism and disposition via the regulation of target ADME gene expression. Acta pharmaceutica Sinica B. 2019;9:639-47.
Not in our library10.1016/j.apsb.2018.12.002
- 177.
Endogenous, cholesterol-activated ATP-dependent transport in membrane vesicles from Spodoptera frugiperda cells. Eur J Pharm Sci. 2019;137:104963.
Not in our library10.1016/j.ejps.2019.104963
- 178.
MicroRNA regulates the expression of human cytochrome P450 1B1. Cancer Res. 2006;66:9090-8.
Not in our library10.1158/0008-5472.can-06-1403
- 179.
SPIN1, negatively regulated by miR-148/152, enhances Adriamycin resistance via upregulating drug metabolizing enzymes and transporter in breast cancer. Journal of experimental & clinical cancer research: CR. 2018;37:100.
Not in our library10.1186/s13046-018-0748-9
- 180.
Multiple drug resistance mechanisms in cancer. Molecular biotechnology. 2010;46:308-16.
Not in our library10.1007/s12033-010-9321-2
- 181.
MiR-138 indirectly regulates the MDR1 promoter by NF-kappaB/p65 silencing. Biochemical and biophysical research communications. 2017;484:648-55.
Not in our library10.1016/j.bbrc.2017.01.168
- 182.
Changes in the expression of miR-381 and miR-495 are inversely associated with the expression of the MDR1 gene and development of multi-drug resistance. PloS one. 2013;8:e82062.
Not in our library10.1371/journal.pone.0082062
- 183.
STAT3: A Promising Therapeutic Target in Multiple Myeloma. Cancers (Basel). 2019;11(5):731.
Not in our library10.3390/cancers11050731
- 184.
Bioinformatics-based interaction analysis of miR-92a-3p and key genes in tamoxifen-resistant breast cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018;107:117-28.
Not in our library10.1016/j.biopha.2018.07.158
- 185.
SRSF3, a Splicer of the PKM Gene, Regulates Cell Growth and Maintenance of Cancer-Specific Energy Metabolism in Colon Cancer Cells. Int J Mol Sci. 2018;19(10):3012.
Not in our library10.3390/ijms19103012
- 186.
MiR-374b re-sensitizes hepatocellular carcinoma cells to sorafenib therapy by antagonizing PKM2-mediated glycolysis pathway. American journal of cancer research. 2019;9:765-78.
Not in our library
- 187.
Tumor microenvironment confers mTOR inhibitor resistance in invasive intestinal adenocarcinoma. Oncogene. 2017;36:6480-9.
Not in our library10.1038/onc.2017.242
- 188.
miR-1271 enhances the sensitivity of colorectal cancer cells to cisplatin. Experimental and therapeutic medicine. 2019;17:4363-70.
Not in our library10.3892/etm.2019.7501
- 189.
EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks. Nat Commun. 2019;10:2135.
Not in our library10.1038/s41467-019-10153-9
- 190.
Oncogene RPA1 promotes proliferation of hepatocellular carcinoma via CDK4/Cyclin-D pathway. Biochemical and biophysical research communications. 2018;498:424-30.
Not in our library10.1016/j.bbrc.2018.02.167
- 191.
MicroRNA-146a-5p enhances radiosensitivity in hepatocellular carcinoma through replication protein A3-induced activation of the DNA repair pathway. American journal of physiology Cell physiology. 2019;316:C299-C311.
Not in our library10.1152/ajpcell.00189.2018
- 192.
Role of AKT signaling in DNA repair and clinical response to cancer therapy. Neuro Oncol. 2014;16:1313-23.
Not in our library10.1093/neuonc/nou058
- 193.
MiR-130a exerts neuroprotective effects against ischemic stroke through PTEN/PI3K/AKT pathway. Biomed Pharmacother. 2019;117:109117.
Not in our library10.1016/j.biopha.2019.109117
- 194.
Therapeutic Delivery of miR-29b Enhances Radiosensitivity in Cervical Cancer. Molecular therapy: the journal of the American Society of Gene Therapy. 2019;27:1183-94.
Not in our library10.1016/j.ymthe.2019.03.020
- 195.
Chemoresistance in gastric cancer is attributed to the overexpression of excision repair cross-complementing 1 (ERCC1) caused by microRNA-122 dysregulation. Journal of cellular physiology. 2019;234(12):22485-22492.
Not in our library10.1002/jcp.28812
- 196.
MicroRNA-210 May Be a Preoperative Biomarker of Malignant Pheochromocytomas and Paragangliomas. J Surg Res. 2019;243:1-7.
Not in our library10.1016/j.jss.2019.04.086
- 197.
A panel of seven-miRNA signature in plasma as potential biomarker for colorectal cancer diagnosis. Gene. 2019;687:246-54.
Not in our library10.1016/j.gene.2018.11.055
- 198.
MiRNA-491-5p inhibits cell proliferation, invasion and migration via targeting JMJD2B and serves as a potential biomarker in gastric cancer. Am J Transl Res. 2018;10:525-34.
Not in our library
- 199.
Exosome-encapsulated microRNA-223-3p as a minimally invasive biomarker for the early detection of invasive breast cancer. Oncol Lett. 2018;15:9584-92.
Not in our library10.3892/ol.2018.8457
- 200.
A microRNA signature from serum exosomes of patients with glioma as complementary diagnostic biomarker. J Neurooncol. 2018;136:51-62.
Not in our library10.1007/s11060-017-2639-x
- 201.
A two-miRNA signature (miR-33a-5p and miR-128-3p) in whole blood as potential biomarker for early diagnosis of lung cancer. Scientific reports. 2018;8:16699.
Not in our library10.1038/s41598-018-35139-3
- 202.
MicroRNA-214 targets PTK6 to inhibit tumorigenic potential and increase drug sensitivity of prostate cancer cells. Scientific reports. 2019;9:9776.
Not in our library10.1038/s41598-019-46170-3
- 203.
miR-221 suppression through nanoparticle-based miRNA delivery system for hepatocellular carcinoma therapy and its diagnosis as a potential biomarker. Int J Nanomedicine. 2018;13:2295-307.
Not in our library10.2147/ijn.s157805
- 204.
Serum Levels of MicroRNA miR-371a-3p: A Sensitive and Specific New Biomarker for Germ Cell Tumours. Eur Urol. 2017;71:213-20.
Not in our library10.1016/j.eururo.2016.07.029
- 205.
Circulating MicroRNA-92b-3p as a Novel Biomarker for Monitoring of Synovial Sarcoma. Scientific reports. 2017;7:14634.
Not in our library10.1038/s41598-017-12660-5
- 206.
microRNA-944 overexpression is a biomarker for poor prognosis of advanced cervical cancer. BMC Cancer. 2019;19:419.
Not in our library10.1186/s12885-019-5620-6
- 207.
Circulating miRNA-1290 as a potential biomarker for response to chemoradiotherapy and prognosis of patients with advanced oral squamous cell carcinoma: A single-center retrospective study. Tumour Biol. 2019;41:1010428319826853.
Not in our library10.1177/1010428319826853
- 208.
CircRNA circ_0026344 as a prognostic biomarker suppresses colorectal cancer progression via microRNA-21 and microRNA-31. Biochem Biophys Res Commun. 2018;503:870-5.
Not in our library10.1016/j.bbrc.2018.06.089
- 209.
Usefulness of exosome-encapsulated microRNA-451a as a minimally invasive biomarker for prediction of recurrence and prognosis in pancreatic ductal adenocarcinoma. J Hepatobiliary Pancreat Sci. 2018;25:155-61.
Not in our library10.1002/jhbp.524
- 210.
miRNA profiling of small intestinal neuroendocrine tumors defines novel molecular subtypes and identifies miR-375 as a biomarker of patient survival. Mod Pathol. 2018;31:1302-17.
Not in our library10.1038/s41379-018-0010-1
- 211.
Identification of a sixteen-microRNA signature as prognostic biomarker for stage II and III colon cancer. Oncotarget. 2017;8:87837-47.
Not in our library10.18632/oncotarget.21237
- 212.
- 213.
MicroRNA-296-5p Promotes Cell Invasion and Drug Resistance by Targeting Bcl2-Related Ovarian Killer, Leading to a Poor Prognosis in Pancreatic Cancer. Digestion. 2019;1-13.
Not in our library10.1159/000503225
- 214.
MicroRNA-135a-3p as a promising biomarker and nucleic acid therapeutic agent for ovarian cancer. Cancer science. 2017;108:886-96.
Not in our library10.1111/cas.13210
- 215.
MicroRNA-155-5p Overexpression in Peripheral Blood Mononuclear Cells of Chronic Lymphocytic Leukemia Patients Is a Novel, Independent Molecular Biomarker of Poor Prognosis. Dis Markers. 2017;2017:2046545.
Not in our library10.1155/2017/2046545
- 216.
Low Expression of miR-424-3p is Highly Correlated with Clinical Failure in Prostate Cancer. Scientific reports. 2019;9:10662.
Not in our library10.1038/s41598-019-47234-0
- 217.
MicroRNA 362-3p Reduces hERG-related Current and Inhibits Breast Cancer Cells Proliferation. Cancer genomics & proteomics. 2019;16:433-42.
Not in our library10.21873/cgp.20147
- 218.
Identification of a three-miRNA signature as a novel potential prognostic biomarker in patients with clear cell renal cell carcinoma. J Cell Biochem. 2019;120(8):13751-13764.
Not in our library10.1002/jcb.28648
- 219.
Manipulating microRNAs for the Treatment of Malignant Pleural Mesothelioma: Past, Present and Future. Front Oncol. 2020;10:105.
Not in our library10.3389/fonc.2020.00105
- 220.
Non-coding RNAs: the cancer genome dark matter that matters! Clin Chem Lab Med. 2017;55:705-14.
Not in our library10.1515/cclm-2016-0740
- 221.
Role of microRNAs in antiviral responses to dengue infection. J Biomed Sci. 2020;27:4.
Not in our library10.1186/s12929-019-0614-x
- 222.
Expression and Role of MicroRNAs from the miR-200 Family in the Tumor Formation and Metastatic Propensity of Pancreatic Cancer. Mol Ther Nucleic Acids. 2019;17:491-503.
Not in our library10.1016/j.omtn.2019.06.015
- 223.
- 224.
MicroRNA-1294 inhibits the proliferation and enhances the chemosensitivity of glioma to temozolomide via the direct targeting of TPX2. American journal of cancer research. 2018;8:291-301.
Not in our library
- 225.
Up-regulation of miR-383-5p suppresses proliferation and enhances chemosensitivity in ovarian cancer cells by targeting TRIM27. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019;109:595-601.
Not in our library10.1016/j.biopha.2018.10.148
- 226.
- 227.
Exosome-mediated microRNA-497 delivery for anti-cancer therapy in a microfluidic 3D lung cancer model. Lab Chip. 2020;20:548-57.
Not in our library10.1039/c9lc00958b
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