No retraction, correction or concern found when last checked on Oct 20, 2026.

Biofilms: Formation, drug resistance and alternatives to conventional approaches

Ruba Mirghani, Tania Saba, Hebba Khaliq and 11 more

AIMS Microbiology · 2022 · Review

doi:10.3934/microbiol.2022019

Abstract

<abstract> <p>Biofilms are aggregates of bacteria, in most cases, which are resistant usually to broad-spectrum antibiotics in their typical concentrations or even in higher doses. A trend of increasing multi-drug resistance in biofilms, which are responsible for emerging life-threatening nosocomial infections, is becoming a serious problem. Biofilms, however, are at various sensitivity levels to environmental factors and are versatile in infectivity depending on virulence factors. This review presents the fundamental information about biofilms: formation, antibiotic resistance, impacts on public health and alternatives to conventional approaches. Novel developments in micro-biosystems that help reveal the new treatment tools by sensing and characterization of biofilms will also be discussed. Understanding the formation, structure, physiology and properties of biofilms better helps eliminate them by the usage of appropriate antibiotics or their control by novel therapy approaches, such as anti-biofilm molecules, effective gene editing, drug-delivery systems and probiotics.</p> </abstract>

References 297

1.
Silva VO, Soares LO, Silva Júnior A, et al. Biofilm formation on biotic and abiotic surfaces in the presence of antimicrobials by Escherichia coli isolates from cases of bovine mastitis. Appl Environ Microbiol. 2014;80:6136-6145.
Not in our library10.1128/aem.01953-14
2.
Biofilms: Microbial Life on Surfaces · 2002
No notice
3.
Biofilms: The Microbial “Protective Clothing” in Extreme Environments · 2019
No notice
4.
Crenarchaeal biofilm formation under extreme conditions. · 2010
Not checked
5.
Chen Y, Yan F, Chai Y, et al. Biocontrol of tomato wilt disease by Bacillus subtilis isolates from natural environments depends on conserved genes mediating biofilm formation. Environ Microbiol. 2013;15:848-864.
Not in our library10.1111/j.1462-2920.2012.02860.x
6.
Van Houdt R, Michiels CW. Biofilm formation and the food industry, a focus on the bacterial outer surface. J Appl Microbiol. 2010;109:1117-1131.
Not in our library10.1111/j.1365-2672.2010.04756.x
7.
Extracellular polymeric substances, a key element in understanding biofilm phenotype · 2018
No notice
8.
Microbial Extracellular Polymeric Substances (EPSs) in Ocean Systems · 2017
No notice
9.
EPS—Then and Now · 2016
No notice
10.
Role of Multicellular Aggregates in Biofilm Formation · 2016
No notice
11.
Taylor M, Ross K, Bentham R. Legionella, Protozoa and Biofilms: Interactions within complex microbial systems. Microbiol Ecol. 2009;58:538-547.
Not in our library10.1007/s00248-009-9514-z
12.
de Alexandre Sebastião F, Pilarski F, Lemos MVF. Composition of extracellular polymeric substances (EPS) produced by flavobacterium columnare isolated from tropical fish in Brazil. Braz J Microbiol. 2013;44:861-864.
Not in our library10.1590/s1517-83822013005000058
13.
McSwain BS, Irvine RL, Hausner M, et al. Composition and distribution of extracellular polymeric substances in aerobic flocs and granular sludge. Appl Environ Microbiol. 2005;71:1051.
Not in our library10.1128/aem.71.2.1051-1057.2005
14.
López D, Vlamakis H, Kolter R. Biofilms. Cold Spring Harbor Perspect Biol. 2010;2:a000398.
Not in our library10.1101/cshperspect.a000398
15.
Nadell CD, Drescher K, Wingreen NS, et al. Extracellular matrix structure governs invasion resistance in bacterial biofilms. ISME J. 2015;9:1700-1709.
Not in our library10.1038/ismej.2014.246
16.
Davenport EK, Call DR, Beyenal H. Differential protection from tobramycin by extracellular polymeric substances from Acinetobacter baumannii and Staphylococcus aureus biofilms. Antimicrob Agents Chemother. 2014;58:4755-4761.
Not in our library10.1128/aac.03071-14
17.
Donlan RM. Biofilm formation: A clinically relevant microbiological process. Clin Infect Dis. 2001;33:1387-1392.
Not in our library10.1086/322972
18.
Lewis K. Persister cells. Annu Rev Microbiol. 2010;64:357-372.
Not in our library10.1146/annurev.micro.112408.134306
19.
Rumbaugh KP, Sauer K. Biofilm dispersion. Nat Rev Microbiol. 2020;18:571-586.
Not in our library10.1038/s41579-020-0385-0
20.
Rice SA, Tan CH, Mikkelsen PJ, et al. The biofilm life cycle and virulence of Pseudomonas aeruginosa are dependent on a filamentous prophage. ISME J. 2009;3:271-282.
Not in our library10.1038/ismej.2008.109
21.
Garrett TR, Bhakoo M, Zhang Z. Bacterial adhesion and biofilms on surfaces. Prog Nat Sci. 2008;18:1049-1056.
Not in our library10.1016/j.pnsc.2008.04.001
22.
Biofilms and Device-Associated Infections · 2001
No notice
23.
Donlan RM, Costerton JW. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev. 2002;15:167-193.
Not in our library10.1128/cmr.15.2.167-193.2002
24.
Armbruster CR, Parsek MR. New insight into the early stages of biofilm formation. Proc Natl Acad Sci. 2018;115:4317.
Not in our library10.1073/pnas.1804084115
25.
Da Cunda P, Iribarnegaray V, Papa-Ezdra R, et al. Characterization of the different stages of biofilm formation and antibiotic susceptibility in a clinical acinetobacter baumannii Strain. Microb Drug Resist. 2019;26:569-575.
Not in our library10.1089/mdr.2019.0145
26.
The Formation of Biofilms by Pseudomonas aeruginosa : A Review of the Natural and Synthetic Compounds Interfering with Control Mechanisms · 2015
No notice
27.
Koczan JM, Lenneman BR, McGrath MJ, et al. Cell surface attachment structures contribute to biofilm formation and xylem colonization by Erwinia amylovora. Appl Environ Microbiol. 2011;77:7031-7039.
Not in our library10.1128/aem.05138-11
28.
Mandlik A, Swierczynski A, Das A, et al. Pili in Gram-positive bacteria: assembly, involvement in colonization and biofilm development. Trends Microbiol. 2008;16:33-40.
Not in our library10.1016/j.tim.2007.10.010
29.
Berne C, Ducret A, Hardy GG, et al. Adhesins involved in attachment to abiotic surfaces by Gram-Negative bacteria. Microbiol Spectrum. 2015;3:10.
Not in our library10.1128/microbiolspec.mb-0018-2015
30.
Dunne WM. Bacterial adhesion: seen any good biofilms lately? Clin Microbiol Rev. 2002;15:155-166.
Not in our library10.1128/cmr.15.2.155-166.2002
31.
Renner LD, Weibel DB. Physicochemical regulation of biofilm formation. MRS Bull. 2011;36:347-355.
Not in our library10.1557/mrs.2011.65
32.
Hinsa SM, Espinosa-Urgel M, Ramos JL, et al. Transition from reversible to irreversible attachment during biofilm formation by Pseudomonas fluorescens WCS365 requires an ABC transporter and a large secreted protein. Mol Microbiol. 2003;49:905-918.
Not in our library10.1046/j.1365-2958.2003.03615.x
33.
Petrova OE, Sauer K. Sticky situations: key components that control bacterial surface attachment. J Bacteriol Res. 2012;194:2413-2425.
Not in our library10.1128/jb.00003-12
34.
Miller JK, Badawy HT, Clemons C, et al. Development of the Pseudomonas aeruginosa mushroom morphology and cavity formation by iron-starvation: a mathematical modeling study. J Theor Biol. 2012;308:68-78.
Not in our library10.1016/j.jtbi.2012.05.029
35.
The Role of Bacterial Biofilm in Antibiotic Resistance and Food Contamination · 2020
No notice
36.
Jefferson KK. What drives bacteria to produce a biofilm? FEMS Microbiol Lett. 2004;236:163-173.
Not in our library10.1111/j.1574-6968.2004.tb09643.x
37.
Kurmoo Y, Hook AL, Harvey D, et al. Real time monitoring of biofilm formation on coated medical devices for the reduction and interception of bacterial infections. Biomater Sci. 2020;8:1464-1477.
Not in our library10.1039/c9bm00875f
38.
Salgar-Chaparro SJ, Lepkova K, Pojtanabuntoeng T, et al. Nutrient level determines biofilm characteristics and subsequent impact on microbial corrosion and biocide effectiveness. Appl Environ Microbiol. 2020;86:e02885-02819.
Not in our library10.1128/aem.02885-19
39.
Wilson C, Lukowicz R, Merchant S, et al. Quantitative and qualitative assessment methods for biofilm growth: A mini-review. Res Rev J Eng Technol. 2017;6.
Not in our library
40.
Critical Assessment of Methods to Quantify Biofilm Growth and Evaluate Antibiofilm Activity of Host Defence Peptides · 2018
No notice
41.
Kaplan JB. Biofilm dispersal: mechanisms, clinical implications, and potential therapeutic uses. J Dent Res. 2010;89:205-218.
Not in our library10.1177/0022034509359403
42.
Rabin N, Zheng Y, Opoku-Temeng C, et al. Biofilm formation mechanisms and targets for developing antibiofilm agents. Future Med Chem. 2015;7:493-512.
Not in our library10.4155/fmc.15.6
43.
Sharpton TJ, Combrink L, Arnold HK, et al. Erratum to “Harnessing the gut microbiome in the fight against anthelminthic drug resistance”. Curr Opin Microbiol. 2021;53:26-34.
Not in our library10.1016/j.mib.2021.01.003
44.
Seth AK, Geringer MR, Hong SJ, et al. Comparative analysis of single-species and polybacterial wound biofilms using a quantitative, in vivo, rabbit ear model. PLoS One. 2012;7:e42897.
Not in our library10.1371/journal.pone.0042897
45.
Yang L, Liu Y, Wu H, et al. Current understanding of multi-species biofilms. Int J Oral Sci. 2011;3:74-81.
Not in our library10.4248/ijos11027
46.
Lohse MB, Gulati M, Johnson AD, et al. Development and regulation of single- and multi-species Candida albicans biofilms. Nat Rev Microbiol. 2018;16:19-31.
Not in our library10.1038/nrmicro.2017.107
47.
Lynch AS, Robertson GT. Bacterial and fungal biofilm infections. Annu Rev Med. 2008;59:415-428.
Not in our library10.1146/annurev.med.59.110106.132000
48.
Seneviratne G, Zavahir JS, Bandara WMMS, et al. Fungal-bacterial biofilms: their development for novel biotechnological applications. World J Microbiol Biotechnol. 2007;24:739.
Not in our library10.1007/s11274-007-9539-8
49.
Guo YS, Furrer JM, Kadilak AL, et al. Bacterial extracellular polymeric substances amplify water content variability at the pore scale. Front Environ Sci. 2018;6.
Not in our library10.3389/fenvs.2018.00093
50.
Wingender J, Neu TR, Flemming HC, et al. What are bacterial extracellular polymeric substances? Microbial extracellular polymeric substances: Characterization, structure and function. 1999;1-19.
Not in our library10.1007/978-3-642-60147-7_1
51.
Wilking JN, Zaburdaev V, De Volder M, et al. Liquid transport facilitated by channels in Bacillus subtilis biofilms. Proc Natl Acad Sci U S A. 2013;110:848-852.
Not in our library10.1073/pnas.1216376110
52.
Microbial Extracellular Polymeric Substances: Ecological Function and Impact on Soil Aggregation · 2018
No notice
53.
Navarre WW, Schneewind O. Surface proteins of gram-positive bacteria and mechanisms of their targeting to the cell wall envelope. Microbiol Mol Biol Rev. 1999;63:174.
Not in our library10.1128/mmbr.63.1.174-229.1999
54.
Davey ME, O'Toole GA. Microbial biofilms: from ecology to molecular genetics. Microbiol Mol Biol Rev: MMBR. 2000;64:847-867.
Not in our library10.1128/mmbr.64.4.847-867.2000
55.
Hibiya K, Tsuneda S, Hirata A. Formation and characteristics of nitrifying biofilm on a membrane modified with positively-charged polymer chains. Colloids Surf, B. 2000;18:105-112.
Not in our library10.1016/s0927-7765(99)00141-1
56.
Navada S, Knutsen MF, Bakke I, et al. Nitrifying biofilms deprived of organic carbon show higher functional resilience to increases in carbon supply. Sci Rep. 2020;10:7121.
Not in our library10.1038/s41598-020-64027-y
57.
Hunt SM, Werner EM, Huang B, et al. Hypothesis for the role of nutrient starvation in biofilm detachment. Appl Environ Microbiol. 2004;70:7418-7425.
Not in our library10.1128/aem.70.12.7418-7425.2004
58.
Maddela NR, Zhou Z, Yu Z, et al. Functional determinants of extracellular polymeric substances in membrane biofouling: Experimental evidence from pure-cultured sludge bacteria. Appl Environ Microbiol. 2018;84:e00756-00718.
Not in our library10.1128/aem.00756-18
59.
Stoodley P, Sauer K, Davies DG, et al. Biofilms as complex differentiated communities. Annu Rev Microbiol. 2002;56:187-209.
Not in our library10.1146/annurev.micro.56.012302.160705
60.
Limoli DH, Jones CJ, Wozniak DJ. Bacterial extracellular polysaccharides in biofilm formation and function. Microbiol Spectrum. 2015;3:10.
Not in our library10.1128/microbiolspec.mb-0011-2014
61.
Magana M, Sereti C, Ioannidis A, et al. Options and limitations in clinical investigation of bacterial biofilms. Clin Microbiol Rev. 2018;31:e00084-16.
Not in our library10.1128/cmr.00084-16
62.
Denef VJ, Mueller RS, Banfield JF. AMD biofilms: using model communities to study microbial evolution and ecological complexity in nature. ISME J. 2010;4:599-610.
Not in our library10.1038/ismej.2009.158
63.
Martinez-Gil M, Goh KGK, Rackaityte E, et al. YeeJ is an inverse autotransporter from Escherichia coli that binds to peptidoglycan and promotes biofilm formation. Sci Rep. 2017;7:11326.
Not in our library10.1038/s41598-017-10902-0
64.
Beloin C, Roux A, Ghigo JM. Escherichia coli biofilms. Curr Top Microbio Immunol. 2008;322:249-289.
Not in our library10.1007/978-3-540-75418-3_12
65.
Klemm P, Hjerrild L, Gjermansen M, et al. Structure-function analysis of the self-recognizing Antigen 43 autotransporter protein from Escherichia coli. Mol Microbiol. 2004;51:283-296.
Not in our library10.1046/j.1365-2958.2003.03833.x
66.
Müller D, Benz I, Tapadar D, et al. Arrangement of the translocator of the autotransporter adhesin involved in diffuse adherence on the bacterial surface. Infect Immun. 2005;73:3851-3859.
Not in our library10.1128/iai.73.7.3851-3859.2005
67.
Barnhart MM, Chapman MR. Curli biogenesis and function. Annu Rev Microbiol. 2006;60:131-147.
Not in our library10.1146/annurev.micro.60.080805.142106
68.
Tursi SA, Tükel Ç. Curli-Containing enteric biofilms inside and out: Matrix composition, immune recognition, and disease implications. Microbiol Mol Biol Rev. 2018;82:e00028-18.
Not in our library10.1128/mmbr.00028-18
69.
Giving structure to the biofilm matrix: an overview of individual strategies and emerging common themes · 2015
No notice
70.
Chen XD, Zhang CK, Zhou Z, et al. Stabilizing effects of bacterial biofilms: EPS penetration and redistribution of bed stability down the sediment profile. J Geophys Res: Biogeosci. 2017;122:3113-3125.
Not in our library10.1002/2017jg004050
71.
Mechanisms and Regulation of Extracellular DNA Release and Its Biological Roles in Microbial Communities · 2017
No notice
72.
Jamal M, Ahmad W, Andleeb S, et al. Bacterial biofilm and associated infections. J Chin Med Assoc. 2018;81:7-11.
Not in our library10.1016/j.jcma.2017.07.012
73.
Toyofuku M, Inaba T, Kiyokawa T, et al. Environmental factors that shape biofilm formation. Biosci Biotechnol Biochem. 2016;80:7-12.
Not in our library10.1080/09168451.2015.1058701
74.
Bacterial Extracellular Polysaccharides Involved in Biofilm Formation · 2009
No notice
75.
Skariyachan S, Sridhar VS, Packirisamy S, et al. Recent perspectives on the molecular basis of biofilm formation by Pseudomonas aeruginosa and approaches for treatment and biofilm dispersal. Folia Microbiol. 2018;63:413-432.
Not in our library10.1007/s12223-018-0585-4
76.
Mann EE, Wozniak DJ. Pseudomonas biofilm matrix composition and niche biology. FEMS Microbiol Rev. 2012;36:893-916.
Not in our library10.1111/j.1574-6976.2011.00322.x
77.
Zambrano MM, Kolter R. Mycobacterial biofilms: A greasy way to hold it together. Cell. 2005;123:762-764.
Not in our library10.1016/j.cell.2005.11.011
78.
Quorum Sensing and Bacterial Social Interactions in Biofilms · 2012
No notice
79.
Antibiotics versus biofilm: an emerging battleground in microbial communities · 2019
No notice
80.
Shrout JD, Chopp DL, Just CL, et al. The impact of quorum sensing and swarming motility on Pseudomonas aeruginosa biofilm formation is nutritionally conditional. Mol Microbiol. 2006;62:1264-1277.
Not in our library10.1111/j.1365-2958.2006.05421.x
81.
Saygin H, Baysal A. Biofilm formation of clinically important bacteria on bio-based and conventional micro/submicron-sized plastics. Bull Environ Contam Toxicol. 2020;105:18-25.
Not in our library10.1007/s00128-020-02876-z
82.
Fulaz S, Vitale S, Quinn L, et al. Nanoparticle-Biofilm interactions: The role of the EPS matrix. Trends Microbiol. 2019;27:915-926.
Not in our library10.1016/j.tim.2019.07.004
83.
Chakraborty P, Kumar A. The extracellular matrix of mycobacterial biofilms: could we shorten the treatment of mycobacterial infections? Microb Cell (Graz,Austria). 2019;6:105-122.
Not in our library10.15698/mic2019.02.667
84.
Yawata Y, Uchiyama H, Nomura N. Visualizing the effects of biofilm structures on the influx of fluorescent material using combined confocal reflection and fluorescent microscopy. Microbes Environ. 2010;25:49-52.
Not in our library10.1264/jsme2.me09169
85.
Holman HY, Miles R, Hao Z, et al. Real-time chemical imaging of bacterial activity in biofilms using open-channel microfluidics and synchrotron FTIR spectromicroscopy. Anal Chem. 2009;81:8564-8570.
Not in our library10.1021/ac9015424
86.
Mattana S, Alunni Cardinali M, Caponi S, et al. High-contrast brillouin and raman micro-spectroscopy for simultaneous mechanical and chemical investigation of microbial biofilms. Biophys Chem. 2017;229:123-129.
Not in our library10.1016/j.bpc.2017.06.008
87.
Abadian PN, Tandogan N, Jamieson JJ, et al. Using surface plasmon resonance imaging to study bacterial biofilms. Biomicrofluidics. 2014;8:021804.
Not in our library10.1063/1.4867739
88.
McGoverin C, Vanholsbeeck F, Dawes JM, et al. Asia-pacific optical sensors conference: focus issue introduction. Opt Express. 2020;28:21745-21748.
Not in our library10.1364/oe.401277
89.
Yuan Y, Guo T, Qiu X, et al. Electrochemical surface plasmon resonance fiber-optic sensor: In situ detection of electroactive biofilms. Anal Chem. 2016;88:7609-7616.
Not in our library10.1021/acs.analchem.6b01314
90.
Microsystems for biofilm characterization and sensing – A review · 2020
Not checked
91.
Stöckl M, Schlegel C, Sydow A, et al. Membrane separated flow cell for parallelized electrochemical impedance spectroscopy and confocal laser scanning microscopy to characterize electro-active microorganisms. Electrochim Acta. 2016;220:444-452.
Not in our library10.1016/j.electacta.2016.10.057
92.
Estrada-Leypon O, Moya A, Guimera A, et al. Simultaneous monitoring of Staphylococcus aureus growth in a multi-parametric microfluidic platform using microscopy and impedance spectroscopy. Bioelectrochemistry. 2015;105:56-64.
Not in our library10.1016/j.bioelechem.2015.05.006
93.
Huiszoon RC, Subramanian S, Ramiah Rajasekaran P, et al. Flexible platform for in situ impedimetric detection and bioelectric effect treatment of Escherichia coli biofilms. IEEE Trans Biomed Eng. 2019;66:1337-1345.
Not in our library10.1109/tbme.2018.2872896
94.
Bayoudh S, Othmane A, Ponsonnet L, et al. Electrical detection and characterization of bacterial adhesion using electrochemical impedance spectroscopy-based flow chamber. Colloids Surf, A. 2008;318:291-300.
Not in our library10.1016/j.colsurfa.2008.01.005
95.
Electrochemical camera chip for simultaneous imaging of multiple metabolites in biofilms · 2016
Not checked
96.
Marcus IM, Herzberg M, Walker SL, et al. Pseudomonas aeruginosa attachment on QCM-D sensors: the role of cell and surface hydrophobicities. Langmuir. 2012;28:6396-6402.
Not in our library10.1021/la300333c
97.
Olsson AL, van der Mei HC, Busscher HJ, et al. Influence of cell surface appendages on the bacterium-substratum interface measured real-time using QCM-D. Langmuir. 2009;25:1627-1632.
Not in our library10.1021/la803301q
98.
Piasecki T, Guła G, Markwitz P, et al. Autonomous system for in situ assay of antibiotic activity on bacterial biofilms using viscosity and density sensing quartz tuning forks. Procedia Eng. 2016;168:745-748.
Not in our library10.1016/j.proeng.2016.11.267
99.
Sfaelou S, Karapanagioti HK, Vakros J. Studying the formation of biofilms on supports with different polarity and their efficiency to treat wastewater. J Chem. 2015;2015:734384.
Not in our library10.1155/2015/734384
100.
Bacterial biofilm formation on implantable devices and approaches to its treatment and prevention · 2018
Not checked
101.
Revdiwala S, Rajdev BM, Mulla S. Characterization of bacterial etiologic agents of biofilm formation in medical devices in critical care setup. Crit Care Res Pract. 2012;2012:945805.
Not in our library10.1155/2012/945805
102.
Trautner BW, Darouiche RO. Role of biofilm in catheter-associated urinary tract infection. Am J Infect Control. 2004;32:177-183.
Not in our library10.1016/j.ajic.2003.08.005
103.
Liu S, Gunawan C, Barraud N, et al. Understanding, monitoring, and controlling biofilm growth in drinking water distribution systems. Environ Sci Technol. 2016;50:8954-8976.
Not in our library10.1021/acs.est.6b00835
104.
Maes S, Vackier T, Nguyen Huu S, et al. Occurrence and characterisation of biofilms in drinking water systems of broiler houses. BMC Microbiol. 2019;19:77.
Not in our library10.1186/s12866-019-1451-5
105.
Beyond Risk: Bacterial Biofilms and Their Regulating Approaches · 2020
No notice
106.
Microbial Contamination of Drinking Water and Human Health from Community Water Systems · 2015
No notice
107.
Archer NK, Mazaitis MJ, Costerton JW, et al. Staphylococcus aureus biofilms: properties, regulation, and roles in human disease. Virulence. 2011;2:445-459.
Not in our library10.4161/viru.2.5.17724
108.
Arciola CR, Campoccia D, Montanaro L. Implant infections: adhesion, biofilm formation and immune evasion. Nat Rev Microbiol. 2018;16:397-409.
Not in our library10.1038/s41579-018-0019-y
109.
Boisvert AA, Cheng MP, Sheppard DC, et al. Microbial biofilms in pulmonary and critical care diseases. Ann Am Thorac Soc. 2016;13:1615-1623.
Not in our library10.1513/annalsats.201603-194fr
110.
Gnanadhas DP, Elango M, Datey A, et al. Chronic lung infection by Pseudomonas aeruginosa biofilm is cured by L-Methionine in combination with antibiotic therapy. Sci Rep. 2015;5:16043.
Not in our library10.1038/srep16043
111.
Sepsis: mechanisms of bacterial injury to the patient · 2019
No notice
112.
VanEpps JS, Younger JG. Implantable device-related infection. Shock (Augusta,Ga). 2016;46:597-608.
Not in our library10.1097/shk.0000000000000692
113.
Stewart PS. Mechanisms of antibiotic resistance in bacterial biofilms. Int J Med Microbiol. 2002;292:107-113.
Not in our library10.1078/1438-4221-00196
114.
Bacterial Biofilm and its Role in the Pathogenesis of Disease · 2020
No notice
115.
González JF, Hahn MM, Gunn JS. Chronic biofilm-based infections: skewing of the immune response. Pathog Dis. 2018;76:fty023.
Not in our library10.1093/femspd/fty023
116.
Elias S, Banin E. Multi-species biofilms: living with friendly neighbors. FEMS Microbiol Rev. 2012;36:990-1004.
Not in our library10.1111/j.1574-6976.2012.00325.x
117.
Extracellular Polymeric Substances Acting as a Permeable Barrier Hinder the Lateral Transfer of Antibiotic Resistance Genes · 2019
Not checked
118.
Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents · 2017
No notice
119.
Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action · 2018
No notice
120.
Koo H, Allan RN, Howlin RP, et al. Targeting microbial biofilms: current and prospective therapeutic strategies. Nat Rev Microbiol. 2017;15:740-755.
Not in our library10.1038/nrmicro.2017.99
121.
Toxicity and Bioremediation of Heavy Metals Contaminated Ecosystem from Tannery Wastewater: A Review · 2018
No notice
122.
Singh R, Paul D, Jain RK. Biofilms: implications in bioremediation. Trends Microbiol. 2006;14:389-397.
Not in our library10.1016/j.tim.2006.07.001
123.
Bispo PJM, Haas W, Gilmore MS. Biofilms in infections of the eye. Pathogens (Basel,Switz). 2015;4:111-136.
Not in our library10.3390/pathogens4010111
124.
Nickel JC, Costerton JW. Bacterial biofilms and catheters: A key to understanding bacterial strategies in catheter-associated urinary tract infection. Can J Infect Dis. 1992;3:261-267.
Not in our library10.1155/1992/517456
125.
Guynn JB, Poretz DM, Duma RJ. Growth of various bacteria in a variety of intravenous fluids. Am J Hosp Pharm. 1973;30:321-325.
Not in our library10.1093/ajhp/30.4.321
126.
Ferrières L, Hancock V, Klemm P. Specific selection for virulent urinary tract infectious Escherichia coli strains during catheter-associated biofilm formation. FEMS Immunol Med Microbiol. 2007;51:212-219.
Not in our library10.1111/j.1574-695x.2007.00296.x
127.
Microbial Biofilms in Urinary Tract Infections and Prostatitis: Etiology, Pathogenicity, and Combating strategies · 2016
No notice
128.
Wiley L, Bridge DR, Wiley LA, et al. Bacterial biofilm diversity in contact lens-related disease: Emerging role of achromobacter, stenotrophomonas, and delftia. Invest Ophthalmol Visual Sci. 2012;53:3896-3905.
Not in our library10.1167/iovs.11-8762
129.
Robertson DM, Parks QM, Young RL, et al. Disruption of contact lens-associated Pseudomonas aeruginosa biofilms formed in the presence of neutrophils. Invest Ophthalmol Visual Sci. 2011;52:2844-2850.
Not in our library10.1167/iovs.10-6469
130.
Litzler PY, Benard L, Barbier-Frebourg N, et al. Biofilm formation on pyrolytic carbon heart valves: influence of surface free energy, roughness, and bacterial species. J Thorac Cardiovasc Surg. 2007;134:1025-1032.
Not in our library10.1016/j.jtcvs.2007.06.013
131.
Piper C, Körfer R, Horstkotte D. Prosthetic valve endocarditis. Heart. 2001;85:590.
Not in our library10.1136/heart.85.5.590
132.
Schaudinn C, Gorur A, Keller D, et al. Periodontitis: an archetypical biofilm disease. J Am Dent Assoc. 2009;140:978-986.
Not in our library10.14219/jada.archive.2009.0307
133.
Naginyte M, Do T, Meade J, et al. Enrichment of periodontal pathogens from the biofilms of healthy adults. Sci Rep. 2019;9:5491.
Not in our library10.1038/s41598-019-41882-y
134.
Chandki R, Banthia P, Banthia R. Biofilms: A microbial home. J Indian Soc Periodontol. 2011;15:111-114.
Not in our library10.4103/0972-124x.84377
135.
Brady RA, Leid JG, Calhoun JH, et al. Osteomyelitis and the role of biofilms in chronic infection. FEMS Immunol Med Microbiol. 2008;52:13-22.
Not in our library10.1111/j.1574-695x.2007.00357.x
136.
Evolving concepts in bone infection: redefining “biofilm”, “acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy” · 2019
No notice
137.
Rochford ETJ, Sabaté Brescó M, Zeiter S, et al. Monitoring immune responses in a mouse model of fracture fixation with and without Staphylococcus aureus osteomyelitis. Bone. 2016;83:82-92.
Not in our library10.1016/j.bone.2015.10.014
138.
Oates A, Bowling FL, Boulton AJM, et al. The visualization of biofilms in chronic diabetic foot wounds using routine diagnostic microscopy methods. J Diabetes Res. 2014;2014:153586.
Not in our library10.1155/2014/153586
139.
Clinton A, Carter T. Chronic wound biofilms: Pathogenesis and potential therapies. Lab Med. 2015;46:277-284.
Not in our library10.1309/lmbnswkui4jpn7so
140.
Bjarnsholt T. The role of bacterial biofilms in chronic infections. APMIS Suppl. 2013;1-51.
Not in our library10.1111/apm.12099
141.
Burmølle M, Thomsen TR, Fazli M, et al. Biofilms in chronic infections-a matter of opportunity-monospecies biofilms in multispecies infections. FEMS Immunol Med Microbiol. 2010;59:324-336.
Not in our library10.1111/j.1574-695x.2010.00714.x
142.
Percival SL, McCarty SM, Lipsky B. Biofilms and wounds: An overview of the evidence. Adv Wound Care. 2015;4:373-381.
Not in our library10.1089/wound.2014.0557
143.
Biofilms: The Stronghold of Legionella pneumophila · 2013
No notice
144.
Høiby N, Ciofu O, Bjarnsholt T. Pseudomonas aeruginosa biofilms in cystic fibrosis. Future Microbiol. 2010;5:1663-1674.
Not in our library10.2217/fmb.10.125
145.
Moreau-Marquis S, Stanton BA, O'Toole GA. Pseudomonas aeruginosa biofilm formation in the cystic fibrosis airway. Pulm Pharmacol Ther. 2008;21:595-599.
Not in our library10.1016/j.pupt.2007.12.001
146.
Lalani T, Kanafani ZA, Chu VH, et al. Prosthetic valve endocarditis due to coagulase-negative staphylococci: findings from the international collaboration on endocarditis merged database. Eur J Clin Microbiol Infect Dis. 2006;25:365-368.
Not in our library10.1007/s10096-006-0141-z
147.
van Steenbergen TJM, van Winkelhoff AJ, de Graaff J. Pathogenic synergy: mixed infections in the oral cavity. Antonie van Leeuwenhoek. 1984;50:789-798.
Not in our library10.1007/bf02386241
148.
Inflammatory responses and inflammation-associated diseases in organs · 2017
No notice
149.
Cytokines in Inflammatory Disease · 2019
No notice
150.
Hall-Stoodley L, Stoodley P, Kathju S, et al. Towards diagnostic guidelines for biofilm-associated infections. FEMS Immunol Med Microbiol. 2012;65:127-145.
Not in our library10.1111/j.1574-695x.2012.00968.x
151.
Olson ME, Ceri H, Morck DW, et al. Biofilm bacteria: formation and comparative susceptibility to antibiotics. Can J Vet Res. 2002;66:86-92.
Not in our library
152.
Mosaddad SA, Tahmasebi E, Yazdanian A, et al. Oral microbial biofilms: an update. Eur J Clin Microbiol Infect Dis. 2019;38:2005-2019.
Not in our library10.1007/s10096-019-03641-9
153.
Fair RJ, Tor Y. Antibiotics and bacterial resistance in the 21st century. Perspect Med Chem. 2014;6:25-64.
Not in our library10.4137/pmc.s14459
154.
Hedberg M, Nord CE. Beta-lactam resistance in anaerobic bacteria: a review. J Chemother. 1996;8:3-16.
Not in our library10.1179/joc.1996.8.1.3
155.
Macià MD, Rojo-Molinero E, Oliver A. Antimicrobial susceptibility testing in biofilm-growing bacteria. Clin Microbiol Infect. 2014;20:981-990.
Not in our library10.1111/1469-0691.12651
156.
Lewis K. Riddle of biofilm resistance. Antimicrob Agents Chemother. 2001;45:999.
Not in our library10.1128/aac.45.4.999-1007.2001
157.
Extracellular polymeric substance (EPS)-degrading enzymes reduce staphylococcal surface attachment and biocide resistance on pig skin in vivo. · 2018
Not checked
158.
Targeted disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate oligosaccharides · 2018
No notice
159.
Wozniak DJ, Wyckoff TJ, Starkey M, et al. Alginate is not a significant component of the extracellular polysaccharide matrix of PA14 and PAO1 Pseudomonas aeruginosa biofilms. Proc Natl Acad Sci U S A. 2003;100:7907-7912.
Not in our library10.1073/pnas.1231792100
160.
Madsen JS, Burmølle M, Hansen LH, et al. The interconnection between biofilm formation and horizontal gene transfer. FEMS Immunol Med Microbiol. 2012;65:183-195.
Not in our library10.1111/j.1574-695x.2012.00960.x
161.
Lister PD, Wolter DJ, Hanson ND. Antibacterial-resistant Pseudomonas aeruginosa: clinical impact and complex regulation of chromosomally encoded resistance mechanisms. Clin Microbiol Rev. 2009;22:582-610.
Not in our library10.1128/cmr.00040-09
162.
Wilton M, Charron-Mazenod L, Moore R, et al. Extracellular DNA acidifies biofilms and induces aminoglycoside resistance in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2015;60:544-553.
Not in our library10.1128/aac.01650-15
163.
Extracellular DNA Chelates Cations and Induces Antibiotic Resistance in Pseudomonas aeruginosa Biofilms · 2008
No notice
164.
Heilmann C, Hartleib J, Hussain MS, et al. The multifunctional Staphylococcus aureus autolysin aaa mediates adherence to immobilized fibrinogen and fibronectin. Infect Immunol. 2005;73:4793-4802.
Not in our library10.1128/iai.73.8.4793-4802.2005
165.
Heilmann C, Hussain M, Peters G, et al. Evidence for autolysin-mediated primary attachment of Staphylococcus epidermidis to a polystyrene surface. Mol Microbiol. 1997;24:1013-1024.
Not in our library10.1046/j.1365-2958.1997.4101774.x
166.
Ch'ng JH, Chong KKL, Lam LN, et al. Biofilm-associated infection by enterococci. Nat Rev Microbiol. 2019;17:82-94.
Not in our library10.1038/s41579-018-0107-z
167.
Restructuring of Enterococcus faecalis biofilm architecture in response to antibiotic-induced stress · 2017
Not checked
168.
Definitions and guidelines for research on antibiotic persistence · 2019
Corrected
169.
Schilcher K, Horswill AR. Staphylococcal biofilm development: Structure, regulation, and treatment strategies. Microbiol Mol Biol Rev. 2020;84:e00026-19.
Not in our library10.1128/mmbr.00026-19
170.
Convergence of Staphylococcus aureus Persister and Biofilm Research: Can Biofilms Be Defined as Communities of Adherent Persister Cells? · 2016
No notice
171.
Staphylococcus aureus biofilms: recent developments in biofilm dispersal · 2014
No notice
172.
Antibiotic Resistance Related to Biofilm Formation in Klebsiella pneumoniae · 2014
No notice
173.
Biofilm formation and antibiotic resistance of Klebsiella pneumoniae isolated from clinical samples in a tertiary care hospital, Klaten, Indonesia · 2019
No notice
174.
Ramos-Vivas J, Chapartegui-González I, Fernández-Martínez M, et al. Biofilm formation by multidrug resistant Enterobacteriaceae strains isolated from solid organ transplant recipients. Sci Rep. 2019;9:8928.
Not in our library10.1038/s41598-019-45060-y
175.
Biofilm Formation in Acinetobacter Baumannii: Genotype-Phenotype Correlation · 2019
No notice
176.
Smani Y, McConnell MJ, Pachón J, et al. Role of fibronectin in the adhesion of Acinetobacter baumannii to host cells. PLoS One. 2012;7:e33073.
Not in our library10.1371/journal.pone.0033073
177.
Gaddy JA, Tomaras AP, Actis LA. The Acinetobacter baumannii 19606 OmpA protein plays a role in biofilm formation on abiotic surfaces and in the interaction of this pathogen with eukaryotic cells. Infect Immun. 2009;77:3150-3160.
Not in our library10.1128/iai.00096-09
178.
Study of biofilm formation and antibiotic resistance pattern of gram-negative Bacilli among the clinical isolates at BPKIHS, Dharan · 2019
Not checked
179.
Poulsen LK, Ballard G, Stahl DA. Use of rRNA fluorescence in situ hybridization for measuring the activity of single cells in young and established biofilms. Appl Environ Microbiol. 1993;59:1354-1360.
Not in our library10.1128/aem.59.5.1354-1360.1993
180.
Sternberg C, Christensen BB, Johansen T, et al. Distribution of bacterial growth activity in flow-chamber biofilms. Appl Environ Microbiol. 1999;65:4108-4117.
Not in our library10.1128/aem.65.9.4108-4117.1999
181.
Mitchison JM. Enzyme synthesis in synchronous cultures. Science. 1969;165:657-663.
Not in our library10.1126/science.165.3894.657
182.
Gilbert P, Maira-Litran T, McBain AJ, et al. The physiology and collective recalcitrance of microbial biofilm communities. Adv Microb Physiol. 2002;46:202-256.
Not in our library10.1016/s0065-2911(02)46005-5
183.
Walters MC, Roe F, Bugnicourt A, et al. Contributions of antibiotic penetration, oxygen limitation, and low metabolic activity to tolerance of Pseudomonas aeruginosa biofilms to ciprofloxacin and tobramycin. Antimicrob Agents Chemother. 2003;47:317-323.
Not in our library10.1128/aac.47.1.317-323.2003
184.
Tresse O, Jouenne T, Junter GA. The role of oxygen limitation in the resistance of agar-entrapped, sessile-like Escherichia coli to aminoglycoside and beta-lactam antibiotics. J Antimicrob Chemother. 1995;36:521-526.
Not in our library10.1093/jac/36.3.521
185.
Hall CW, Mah TF. Molecular mechanisms of biofilm-based antibiotic resistance and tolerance in pathogenic bacteria. FEMS Microbiol Rev. 2017;41:276-301.
Not in our library10.1093/femsre/fux010
186.
Zheng Z, Stewart PS. Growth limitation of Staphylococcus epidermidis in biofilms contributes to rifampin tolerance. Biofilms. 2004;1:31-35.
Not in our library10.1017/s1479050503001042
187.
Mah TFC, O'Toole GA. Mechanisms of biofilm resistance to antimicrobial agents. Trends Microbiol. 2001;9:34-39.
Not in our library10.1016/s0966-842x(00)01913-2
188.
Quorum-Sensing Regulation of Antimicrobial Resistance in Bacteria · 2020
No notice
189.
Shih PC, Huang CT. Effects of quorum-sensing deficiency on Pseudomonas aeruginosa biofilm formation and antibiotic resistance. J Antimicrob Chemother. 2002;49:309-314.
Not in our library10.1093/jac/49.2.309
190.
Algburi A, Comito N, Kashtanov D, et al. Control of biofilm formation: Antibiotics and beyond. Appl Environ Microbiol. 2017;83:e02508-02516.
Not in our library10.1128/aem.02508-16
191.
Advancing antimicrobial strategies for managing oral biofilm infections · 2019
No notice
192.
Klemm P, Vejborg RM, Hancock V. Prevention of bacterial adhesion. Appl Microbiol Biotechnol. 2010;88:451-459.
Not in our library10.1007/s00253-010-2805-y
193.
Veerachamy S, Yarlagadda T, Manivasagam G, et al. Bacterial adherence and biofilm formation on medical implants: A review. Proc Inst Mech Eng, Part H. 2014;228:1083-1099.
Not in our library10.1177/0954411914556137
194.
Chow JY, Yang Y, Tay SB, et al. Disruption of biofilm formation by the human pathogen Acinetobacter baumannii using engineered quorum-quenching lactonases. Antimicrob Agents Chemother. 2014;58:1802-1805.
Not in our library10.1128/aac.02410-13
195.
Prevention of biofilm formation and removal of existing biofilms by extracellular DNases of Campylobacter jejuni. · 2015
Not checked
196.
Targeting Biofilms Therapy: Current Research Strategies and Development Hurdles · 2020
No notice
197.
Gil C, Solano C, Burgui S, et al. Biofilm matrix exoproteins induce a protective immune response against Staphylococcus aureus biofilm infection. Infect Immun. 2014;82:1017-1029.
Not in our library10.1128/iai.01419-13
198.
Jiang Q, Jin Z, Sun B. MgrA negatively regulates biofilm formation and detachment by repressing the expression of psm operons in Staphylococcus aureus. Appl Environ Microbiol. 2018;84.
Not in our library10.1128/aem.01008-18
199.
Approaches to Dispersing Medical Biofilms · 2017
No notice
200.
Gallant CV, Daniels C, Leung JM, et al. Common beta-lactamases inhibit bacterial biofilm formation. Mol Microbiol. 2005;58:1012-1024.
Not in our library10.1111/j.1365-2958.2005.04892.x
201.
Reza A, Sutton JM, Rahman KM. Effectiveness of efflux pump inhibitors as biofilm disruptors and resistance breakers in Gram-Negative (ESKAPEE) bacteria. Antibiotics (Basel,Switz). 2019;8:229.
Not in our library10.3390/antibiotics8040229
202.
Ciofu O, Rojo-Molinero E, Macià MD, et al. Antibiotic treatment of biofilm infections. APMIS. 2017;125:304-319.
Not in our library10.1111/apm.12673
203.
Brooun A, Liu S, Lewis K. A dose-response study of antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrob Agents Chemother. 2000;44:640-646.
Not in our library10.1128/aac.44.3.640-646.2000
204.
Danese PN. Antibiofilm Approaches: Prevention of Catheter Colonization. Chem Biol. 2002;9:873-880.
Not in our library10.1016/s1074-5521(02)00192-8
205.
Flemming HC, Ridgway H, Flemming HC, Murthy PS, Venkatesan R, et al. Biofilm control: Conventional and alternative approaches. Marine and Industrial Biofouling. 2009;103-117.
Not in our library10.1007/978-3-540-69796-1_5
206.
Sambanthamoorthy K, Gokhale AA, Lao W, et al. Identification of a novel benzimidazole that inhibits bacterial biofilm formation in a broad-spectrum manner. Antimicrob Agents Chemother. 2011;55:4369.
Not in our library10.1128/aac.00583-11
207.
Dinicola S, De Grazia S, Carlomagno G, et al. N-acetylcysteine as powerful molecule to destroy bacterial biofilms. A systematic review. Eur Rev Med Pharmacol Sci. 2014;18:2942-2948.
Not in our library
208.
Abraham NM, Lamlertthon S, Fowler VG, et al. Chelating agents exert distinct effects on biofilm formation in Staphylococcus aureus depending on strain background: role for clumping factor B. J Med Microbiol. 2012;61:1062-1070.
Not in our library10.1099/jmm.0.040758-0
209.
Antoci V, Adams CS, Parvizi J, et al. The inhibition of Staphylococcus epidermidis biofilm formation by vancomycin-modified titanium alloy and implications for the treatment of periprosthetic infection. Biomaterials. 2008;29:4684-4690.
Not in our library10.1016/j.biomaterials.2008.08.016
210.
Ma Y, Chen M, Jones JE, et al. Inhibition of Staphylococcus epidermidis biofilm by trimethylsilane plasma coating. Antimicrob Agents Chemother. 2012;56:5923-5937.
Not in our library10.1128/aac.01739-12
211.
Sanyasi S, Majhi RK, Kumar S, et al. Polysaccharide-capped silver nanoparticles inhibit biofilm formation and eliminate multi-drug-resistant bacteria by disrupting bacterial cytoskeleton with reduced cytotoxicity towards mammalian cells. Sci Rep. 2016;6:24929.
Not in our library10.1038/srep24929
212.
AshaRani PV, Low Kah Mun G, Hande MP, et al. Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano. 2009;3:279-290.
Not in our library10.1021/nn800596w
213.
Raie DS, Mhatre E, Thiele M, et al. Application of quercetin and its bio-inspired nanoparticles as anti-adhesive agents against Bacillus subtilis attachment to surface. Mater Sci Eng, C. 2017;70:753-762.
Not in our library10.1016/j.msec.2016.09.038
214.
Hume EB, Baveja J, Muir B, et al. The control of Staphylococcus epidermidis biofilm formation and in vivo infection rates by covalently bound furanones. Biomaterials. 2004;25:5023-5030.
Not in our library10.1016/j.biomaterials.2004.01.048
215.
Li H, Bao H, Bok KX, et al. High durability and low toxicity antimicrobial coatings fabricated by quaternary ammonium silane copolymers. Biomater Sci. 2016;4:299-309.
Not in our library10.1039/c5bm00353a
216.
Trentin DS, Silva DB, Frasson AP, et al. Natural green coating inhibits adhesion of clinically important bacteria. Sci Rep. 2015;5:8287.
Not in our library10.1038/srep08287
217.
Novel Strategies for the Prevention and Treatment of Biofilm Related Infections · 2013
No notice
218.
Tran PL, Lowry N, Campbell T, et al. An organoselenium compound inhibits Staphylococcus aureus biofilms on hemodialysis catheters in vivo. Antimicrob Agents Chemother. 2012;56:972-978.
Not in our library10.1128/aac.05680-11
219.
Zhao X, Zhao F, Wang J, et al. Biofilm formation and control strategies of foodborne pathogens: food safety perspectives. RSC Adv. 2017;7:36670-36683.
Not in our library10.1039/c7ra02497e
220.
de Sousa DG, Harvey LA, Dorsch S, et al. Interventions involving repetitive practice improve strength after stroke: a systematic review. J Physiother. 2018;64:210-221.
Not in our library10.1016/j.jphys.2018.08.004
221.
Chappell TC, Nair NU. Engineered lactobacilli display anti-biofilm and growth suppressing activities against Pseudomonas aeruginosa. npj Biofilms Microbiomes. 2020;6:48.
Not in our library10.1038/s41522-020-00156-6
222.
Developing natural products as potential anti-biofilm agents · 2019
No notice
223.
Bendaoud M, Vinogradov E, Balashova NV, et al. Broad-spectrum biofilm inhibition by Kingella kingae exopolysaccharide. J Bacteriol Res. 2011;193:3879-3886.
Not in our library10.1128/jb.00311-11
224.
Mi L, Licina GA, Jiang S. Nonantibiotic-Based Pseudomonas aeruginosa biofilm inhibition with osmoprotectant analogues. ACS Sustainable Chem Eng. 2014;2:2448-2453.
Not in our library10.1021/sc500468a
225.
Kuang X, Chen V, Xu X. Novel approaches to the control of oral microbial biofilms. BioMed Res Int. 2018;2018:6498932.
Not in our library10.1155/2018/6498932
226.
Chen H, Zhang B, Weir MD, et al. S. mutans gene-modification and antibacterial resin composite as dual strategy to suppress biofilm acid production and inhibit caries. J Dent. 2020;93:103278.
Not in our library10.1016/j.jdent.2020.103278
227.
Pires DP, Melo LDR, Vilas Boas D, et al. Phage therapy as an alternative or complementary strategy to prevent and control biofilm-related infections. Curr Opin Microbiol. 2017;39:48-56.
Not in our library10.1016/j.mib.2017.09.004
228.
Adjunct phage treatment enhances the effectiveness of low antibiotic concentration against Staphylococcus aureus biofilms in vitro. · 2019
Not checked
229.
Pires DP, Vilas Boas D, Sillankorva S, et al. Phage therapy: a step forward in the treatment of Pseudomonas aeruginosa infections. J Virol. 2015;89:7449-7456.
Not in our library10.1128/jvi.00385-15
230.
Fu W, Forster T, Mayer O, et al. Bacteriophage cocktail for the prevention of biofilm formation by Pseudomonas aeruginosa on catheters in an in vitro model system. Antimicrob Agents Chemother. 2010;54:397-404.
Not in our library10.1128/aac.00669-09
231.
Prevention of biofilm formation by quorum quenching · 2020
No notice
232.
Singh VK, Mishra A, Jha B. Anti-quorum sensing and anti-biofilm activity of delftia tsuruhatensis extract by attenuating the quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa. Front Cell Infect Microbiol. 2017;7.
Not in our library10.3389/fcimb.2017.00337
233.
Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR · 2008
No notice
234.
Kalaiarasan E, Thirumalaswamy K, Harish BN, et al. Inhibition of quorum sensing-controlled biofilm formation in Pseudomonas aeruginosa by quorum-sensing inhibitors. Microb Pathog. 2017;111:99-107.
Not in our library10.1016/j.micpath.2017.08.017
235.
Bulman ZP, Ly NS, Lenhard JR, et al. Influence of rhlR and lasR on polymyxin pharmacodynamics in Pseudomonas aeruginosa and implications for quorum sensing inhibition with azithromycin. Antimicrob Agents Chemother. 2017;61.
Not in our library10.1128/aac.00096-16
236.
Maura D, Rahme LG. Pharmacological inhibition of the Pseudomonas aeruginosa MvfR quorum-sensing system interferes with biofilm formation and potentiates antibiotic-mediated biofilm disruption. Antimicrob Agents Chemother. 2017;61.
Not in our library10.1128/aac.01362-17
237.
Stenvang M, Dueholm MS, Vad BS, et al. Epigallocatechin gallate remodels overexpressed functional amyloids in Pseudomonas aeruginosa and increases biofilm susceptibility to antibiotic treatment*. J Biol Chem. 2016;291:26540-26553.
Not in our library10.1074/jbc.m116.739953
238.
Guo Q, Wei Y, Xia B, et al. Identification of a small molecule that simultaneously suppresses virulence and antibiotic resistance of Pseudomonas aeruginosa. Sci Rep. 2016;6:19141.
Not in our library10.1038/srep19141
239.
Freire MO, Devaraj A, Young A, et al. A bacterial-biofilm-induced oral osteolytic infection can be successfully treated by immuno-targeting an extracellular nucleoid-associated protein. Mol Oral Microbiol. 2017;32:74-88.
Not in our library10.1111/omi.12155
240.
Sun D, Accavitti MA, Bryers JD. Inhibition of biofilm formation by monoclonal antibodies against Staphylococcus epidermidis RP62A accumulation-associated protein. Clin Diagn Lab Immunol. 2005;12:93-100.
Not in our library10.1128/cdli.12.1.93-100.2005
241.
Estellés A, Woischnig AK, Liu K, et al. A high-affinity native human antibody disrupts biofilm from Staphylococcus aureus bacteria and potentiates antibiotic efficacy in a mouse implant infection model. Antimicrob Agents Chemother. 2016;60:2292-2301.
Not in our library10.1128/aac.02588-15
242.
Hall AE, Domanski PJ, Patel PR, et al. Characterization of a protective monoclonal antibody recognizing Staphylococcus aureus MSCRAMM protein clumping factor A. Infect Immun. 2003;71:6864-6870.
Not in our library10.1128/iai.71.12.6864-6870.2003
243.
Visai L, Xu Y, Casolini F, et al. Monoclonal antibodies to CNA, a collagen-binding microbial surface component recognizing adhesive matrix molecules, detach Staphylococcus aureus from a collagen substrate. J Biol Chem. 2000;275:39837-39845.
Not in our library10.1074/jbc.m005297200
244.
Rennermalm A, Li YH, Bohaufs L, et al. Antibodies against a truncated Staphylococcus aureus fibronectin-binding protein protect against dissemination of infection in the rat. Vaccine. 2001;19:3376-3383.
Not in our library10.1016/s0264-410x(01)00080-9
245.
Belyi Y, Rybolovlev I, Polyakov N, et al. Staphylococcus aureus surface protein G is an immunodominant protein and a possible target in an anti-biofilm drug development. Open Microbiol J. 2018;12:94-106.
Not in our library10.2174/1874285801812010094
246.
Haghighat S, Siadat SD, Sorkhabadi SM, et al. Cloning, expression and purification of autolysin from methicillin-resistant Staphylococcus aureus: potency and challenge study in Balb/c mice. Mol Immunol. 2017;82:10-18.
Not in our library10.1016/j.molimm.2016.12.013
247.
Nair N, Vinod V, Suresh MK, et al. Amidase, a cell wall hydrolase, elicits protective immunity against Staphylococcus aureus and S. epidermidis. Int J Biol Macromol. 2015;77:314-321.
Not in our library10.1016/j.ijbiomac.2015.03.047
248.
Varrone JJ, de Mesy Bentley KL, Bello-Irizarry SN, et al. Passive immunization with anti-glucosaminidase monoclonal antibodies protects mice from implant-associated osteomyelitis by mediating opsonophagocytosis of Staphylococcus aureus megaclusters. J Orthop Res. 2014;32:1389-1396.
Not in our library10.1002/jor.22672
249.
van den Berg S, Bonarius HP, van Kessel KP, et al. A human monoclonal antibody targeting the conserved Staphylococcal antigen IsaA protects mice against Staphylococcus aureus bacteremia. Int J Med Microbiol. 2015;305:55-64.
Not in our library10.1016/j.ijmm.2014.11.002
250.
Liu B, Park S, Thompson CD, et al. Antibodies to Staphylococcus aureus capsular polysaccharides 5 and 8 perform similarly in vitro but are functionally distinct in vivo. Virulence. 2017;8:859-874.
Not in our library10.1080/21505594.2016.1270494
251.
Weisman LE. Antibody for the prevention of neonatal noscocomial Staphylococcal infection: a review of the literature. Arch Pediatr. 2007;14 Suppl 1:S31-34.
Not in our library10.1016/s0929-693x(07)80008-x
252.
Raafat D, Otto M, Reppschläger K, et al. Fighting Staphylococcus aureus biofilms with monoclonal antibodies. Trends Microbiol. 2019;27:303-322.
Not in our library10.1016/j.tim.2018.12.009
253.
Freire-Moran L, Aronsson B, Manz C, et al. Critical shortage of new antibiotics in development against multidrug-resistant bacteria-time to react is now. Drug Resist Updat. 2011;14:118-124.
Not in our library10.1016/j.drup.2011.02.003
254.
Banerjee M, Moulick S, Bhattacharya KK, et al. Attenuation of Pseudomonas aeruginosa quorum sensing, virulence and biofilm formation by extracts of Andrographis paniculata. Microb Pathog. 2017;113:85-93.
Not in our library10.1016/j.micpath.2017.10.023
255.
Zhang L, Bao M, Liu B, et al. Effect of andrographolide and its analogs on bacterial infection: A review. Pharmacology. 2020;105:123-134.
Not in our library10.1159/000503410
256.
Rasool U, SP, Parveen A, et al. Efficacy of andrographis paniculata against extended spectrum β-lactamase (ESBL) producing E. coli. BMC Complementary Altern Med. 2018;18:244-244.
Not in our library10.1186/s12906-018-2312-8
257.
Carrol DH, Chassagne F, Dettweiler M, et al. Antibacterial activity of plant species used for oral health against Porphyromonas gingivalis. PLoS One. 2020;15:e0239316.
Not in our library10.1371/journal.pone.0239316
258.
New approaches to combat Porphyromonas gingivalis biofilms · 2017
Not checked
259.
Liu G, Xiang H, Tang X, et al. Transcriptional and functional analysis shows sodium houttuyfonate-mediated inhibition of autolysis in Staphylococcus aureus. Molecules (Basel,Switz). 2011;16:8848-8865.
Not in our library10.3390/molecules16108848
260.
Zhou J, Bi S, Chen H, et al. Anti-Biofilm and antivirulence activities of metabolites from plectosphaerella cucumerina against Pseudomonas aeruginosa. Front Microbiol. 2017;8:769.
Not in our library10.3389/fmicb.2017.00769
261.
Rabin N, Zheng Y, Opoku-Temeng C, et al. Agents that inhibit bacterial biofilm formation. Future Med Chem. 2015;7:647-671.
Not in our library10.4155/fmc.15.7
262.
Xiang H, Cao F, Ming D, et al. Aloe-emodin inhibits Staphylococcus aureus biofilms and extracellular protein production at the initial adhesion stage of biofilm development. Appl Microbiol Biotechnol. 2017;101:6671-6681.
Not in our library10.1007/s00253-017-8403-5
263.
Jakobsen TH, van Gennip M, Phipps RK, et al. Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing. Antimicrob Agents Chemother. 2012;56:2314-2325.
Not in our library10.1128/aac.05919-11
264.
Balcázar JL, Vendrell D, de Blas I, et al. Characterization of probiotic properties of lactic acid bacteria isolated from intestinal microbiota of fish. Aquaculture. 2008;278:188-191.
Not in our library10.1016/j.aquaculture.2008.03.014
265.
Didinen BI, Onuk EE, Metin S, et al. Identification and characterization of lactic acid bacteria isolated from rainbow trout (Oncorhynchus mykiss, Walbaum 1792), with inhibitory activity against Vagococcus salmoninarum and Lactococcus garvieae. Aquacult Nutr. 2018;24:400-407.
Not in our library10.1111/anu.12571
266.
Ben Taheur F, Kouidhi B, Fdhila K, et al. Anti-bacterial and anti-biofilm activity of probiotic bacteria against oral pathogens. Microb Pathog. 2016;97:213-220.
Not in our library10.1016/j.micpath.2016.06.018
267.
Lee DK, Park SY, An HM, et al. Antimicrobial activity of Bifidobacterium spp. isolated from healthy adult Koreans against cariogenic microflora. Arch Oral Biol. 2011;56:1047-1054.
Not in our library10.1016/j.archoralbio.2011.03.002
268.
Schwendicke F, Horb K, Kneist S, et al. Effects of heat-inactivated Bifidobacterium BB12 on cariogenicity of Streptococcus mutans in vitro. Arch Oral Biol. 2014;59:1384-1390.
Not in our library10.1016/j.archoralbio.2014.08.012
269.
Suzuki N, Yoneda M, Hatano Y, et al. Enterococcus faecium WB2000 inhibits biofilm formation by oral cariogenic Streptococci. Int J Dent. 2011;2011:834151.
Not in our library10.1155/2011/834151
270.
Sassone-Corsi M, Raffatellu M. No vacancy: how beneficial microbes cooperate with immunity to provide colonization resistance to pathogens. J immunol. 2015;194:4081-4087.
Not in our library10.4049/jimmunol.1403169
271.
Tuomola EM, Ouwehand AC, Salminen SJ. The effect of probiotic bacteria on the adhesion of pathogens to human intestinal mucus. FEMS Immunol Med Microbiol. 1999;26:137-142.
Not in our library10.1111/j.1574-695x.1999.tb01381.x
272.
Yan F, Polk DB. Probiotics and immune health. Curr Opin Gastroenterol. 2011;27:496-501.
Not in our library10.1097/mog.0b013e32834baa4d
273.
Hegarty JW, Guinane CM, Ross RP, et al. Bacteriocin production: a relatively unharnessed probiotic trait? F1000Res. 2016;5:2587.
Not in our library10.12688/f1000research.9615.1
274.
Corcoran BM, Stanton C, Fitzgerald GF, et al. Survival of probiotic lactobacilli in acidic environments is enhanced in the presence of metabolizable sugars. Appl Environ Microbiol. 2005;71:3060-3067.
Not in our library10.1128/aem.71.6.3060-3067.2005
275.
Vuotto C, Longo F, Donelli G. Probiotics to counteract biofilm-associated infections: promising and conflicting data. Int J Oral Sci. 2014;6:189-194.
Not in our library10.1038/ijos.2014.52
276.
Fang K, Jin X, Hong SH. Probiotic Escherichia coli inhibits biofilm formation of pathogenic E. coli via extracellular activity of DegP. Sci Rep. 2018;8:4939.
Not in our library10.1038/s41598-018-23180-1
277.
Jaffar N, Ishikawa Y, Mizuno K, et al. Mature biofilm degradation by potential probiotics: Aggregatibacter actinomycetemcomitans versus LactoBacillus spp. PLoS One. 2016;11:e0159466.
Not in our library10.1371/journal.pone.0159466
278.
Fighting biofilms with lantibiotics and other groups of bacteriocins · 2018
No notice
279.
Hertzberger R, Arents J, Dekker Henk L, et al. H2O2 production in species of the LactoBacillus acidophilus group: a central role for a novel NADH-Dependent flavin reductase. Appl Environ Microbiol. 2014;80:2229-2239.
Not in our library10.1128/aem.04272-13
280.
Biofilm Forming Lactobacillus: New Challenges for the Development of Probiotics · 2016
No notice
281.
Probiotic Lactobacillus reuteri biofilms produce antimicrobial and anti-inflammatory factors · 2009
No notice
282.
Barzegari A, Kheyrolahzadeh K, Hosseiniyan Khatibi SM, et al. The battle of probiotics and their derivatives against biofilms. Infect Drug Resist. 2020;13:659-672.
Not in our library10.2147/idr.s232982
283.
Anti-biofilm Activity as a Health Issue · 2016
No notice
284.
Tan L, Fu J, Feng F, et al. Engineered probiotics biofilm enhances osseointegration via immunoregulation and anti-infection. Sci Adv. 2020;6:eaba5723.
Not in our library10.1126/sciadv.aba5723
285.
Carvalho FM, Teixeira-Santos R, Mergulhão FJM, et al. The use of probiotics to fight biofilms in medical devices: A systematic review and meta-analysis. Microorganisms. 2020;9.
Not in our library10.3390/microorganisms9010027
286.
Gholizadeh P, Aghazadeh M, Asgharzadeh M, et al. Suppressing the CRISPR/Cas adaptive immune system in bacterial infections. Eur J Clin Microbiol Infect Dis. 2017;36:2043-2051.
Not in our library10.1007/s10096-017-3036-2
287.
Yao R, Liu D, Jia X, et al. CRISPR-Cas9/Cas12a biotechnology and application in bacteria. Synth Syst Biotechnol. 2018;3:135-149.
Not in our library10.1016/j.synbio.2018.09.004
288.
Jiang W, Bikard D, Cox D, et al. RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol. 2013;31:233-239.
Not in our library10.1038/nbt.2508
289.
Goren M, Yosef I, Qimron U. Sensitizing pathogens to antibiotics using the CRISPR-Cas system. Drug Resist Updat. 2017;30:1-6.
Not in our library10.1016/j.drup.2016.11.001
290.
Touchon M, Charpentier S, Pognard D, et al. Antibiotic resistance plasmids spread among natural isolates of Escherichia coli in spite of CRISPR elements. Microbiology (Reading). 2012;158:2997-3004.
Not in our library10.1099/mic.0.060814-0
291.
Hale CR, Majumdar S, Elmore J, et al. Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs. Mol Cell. 2012;45:292-302.
Not in our library10.1016/j.molcel.2011.10.023
292.
Bikard D, Euler CW, Jiang W, et al. Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials. Nat Biotechnol. 2014;32:1146-1150.
Not in our library10.1038/nbt.3043
293.
Cytotoxic Chromosomal Targeting by CRISPR/Cas Systems Can Reshape Bacterial Genomes and Expel or Remodel Pathogenicity Islands · 2013
No notice
294.
Gholizadeh P, Köse Ş, Dao S, et al. How CRISPR-Cas system could be used to combat antimicrobial resistance. Infect Drug Resist. 2020;13:1111-1121.
Not in our library10.2147/idr.s247271
295.
CRISPR Interference (CRISPRi) Inhibition of luxS Gene Expression in E. coli: An Approach to Inhibit Biofilm · 2017
Not checked
296.
Gong T, Tang B, Zhou X, et al. Genome editing in Streptococcus mutans through self-targeting CRISPR arrays. Mol Oral Microbiol. 2018;33:440-449.
Not in our library10.1111/omi.12247
297.
Garrido V, Piñero-Lambea C, Rodriguez-Arce I, et al. Engineering a genome-reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo. Mol Syst Biol. 2021;17:e10145.
Not in our library10.15252/msb.202010145

Cited by papers we hold 1

Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment · 2023
Corrected

Reads

Read by people on this page

None yet.

Checked or read by AI through naulon

None yet.

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.

Are you an author?

Is this your paper?

Claim it to add your note and be paid when agents cite it. Free.