Long Non-Coding RNA in the Pathogenesis of Cancers

Abstract

The incidence and mortality rate of cancer has been quickly increasing in the past decades. At present, cancer has become the leading cause of death worldwide. Most of the cancers cannot be effectively diagnosed at the early stage. Although there are multiple therapeutic treatments, including surgery, radiotherapy, chemotherapy, and targeted drugs, their effectiveness is still limited. The overall survival rate of malignant cancers is still low. It is necessary to further study the mechanisms for malignant cancers, and explore new biomarkers and targets that are more sensitive and effective for early diagnosis, treatment, and prognosis of cancers than traditional biomarkers and methods. Long non-coding RNAs (lncRNAs) are a class of RNA transcripts with a length greater than 200 nucleotides. Generally, lncRNAs are not capable of encoding proteins or peptides. LncRNAs exert diverse biological functions by regulating gene expressions and functions at transcriptional, translational, and post-translational levels. In the past decade, it has been demonstrated that the dysregulated lncRNA profile is widely involved in the pathogenesis of many diseases, including cancer, metabolic disorders, and cardiovascular diseases. In particular, lncRNAs have been revealed to play an important role in tumor growth and metastasis. Many lncRNAs have been shown to be potential biomarkers and targets for the diagnosis and treatment of cancers. This review aims to briefly discuss the latest findings regarding the roles and mechanisms of some important lncRNAs in the pathogenesis of certain malignant cancers, including lung, breast, liver, and colorectal cancers, as well as hematological malignancies and neuroblastoma.

References 388

1. 1.

   Bray F., Ferlay J., Soerjomataram I., Siegel R.L., Torre L.A., Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA A Cancer J. Clin. 2018;68:394-424.

   Not in our library10.3322/caac.21492

2. 2.

   Domingo J.B., Chen J.J., Braun K.L. Colorectal Cancer Screening Compliance among Asian and Pacific Islander Americans. J. Immigr. Minor Health. 2018;20:584-593.

   Not in our library10.1007/s10903-017-0576-6

3. 3.
   The Different Mechanisms of Cancer Drug Resistance: A Brief Review · 2017

   No notice
4. 4.

   Guo T., Li J., Zhang L., Hou W., Wang R., Zhang J., Gao P. Multidimensional communication of microRNAs and long non-coding RNAs in lung cancer. J. Cancer Res. Clin. Oncol. 2019;145:31-48.

   Not in our library10.1007/s00432-018-2767-5

5. 5.

   Novikova I.V., Hennelly S.P., Sanbonmatsu K.Y. Tackling Structures of Long Noncoding RNAs. Int. J. Mol. Sci. 2013;14:23672-23684.

   Not in our library10.3390/ijms141223672

6. 6.

   Kang Y.J., Yang D.C., Kong L., Hou M., Meng Y.Q., Wei L., Gao G. CPC2: A fast and accurate coding potential calculator based on sequence intrinsic features. Nucleic Acids Res. 2017;45:W12-W16.

   Not in our library10.1093/nar/gkx428

7. 7.

   Antonov I.V., Mazurov E., Borodovsky M., Medvedeva Y.A. Prediction of lncRNAs and their interactions with nucleic acids: Benchmarking bioinformatics tools. Brief Bioinform. 2019;20:551-564.

   Not in our library10.1093/bib/bby032

8. 8.

   Zeng P., Chen J., Meng Y., Zhou Y., Yang J., Cui Q. Defining Essentiality Score of Protein-Coding Genes and Long Noncoding RNAs. Front. Genet. 2018;9:380.

   Not in our library10.3389/fgene.2018.00380

9. 9.

   Derrien T., Johnson R., Bussotti G., Tanzer A., Djebali S., Tilgner H., Guernec G., Martín D., Merkel A., Knowles D.G., et al. The GENCODE v7 catalog of human long noncoding RNAs: Analysis of their gene structure, evolution, and expression. Genome Res. 2012;22:1775-1789.

   Not in our library10.1101/gr.132159.111

10. 10.
    Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution · 2015

    No notice
11. 11.

    Qu L., Ding J., Chen C., Wu Z.J., Liu B., Gao Y., Chen W., Liu F., Sun W., Li X.F., et al. Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. Cancer Cell. 2016;29:653-668.

    Not in our library10.1016/j.ccell.2016.03.004

12. 12.

    Guttman M., Rinn J.L. Modular regulatory principles of large non-coding RNAs. Nature. 2012;482:339-346.

    Not in our library10.1038/nature10887

13. 13.

    Iyer M.K., Niknafs Y.S., Malik R., Singhal U., Sahu A., Hosono Y., Barrette T.R., Prensner J.R., Evans J.R., Zhao S., et al. The landscape of long noncoding RNAs in the human transcriptome. Nat. Genet. 2015;47:199-208.

    Not in our library10.1038/ng.3192

14. 14.

    Ransohoff J.D., Wei Y., Khavari P.A. The functions and unique features of long intergenic non-coding RNA. Nat. Rev. Mol. Cell Biol. 2018;19:143-157.

    Not in our library10.1038/nrm.2017.104

15. 15.

    Uszczynska-Ratajczak B., Lagarde J., Frankish A., Guigo R., Johnson R. Towards a complete map of the human long non-coding RNA transcriptome. Nat. Rev. Genet. 2018;19:535-548.

    Not in our library10.1038/s41576-018-0017-y

16. 16.

    Xu Y., Zhang X., Hu X., Zhou W., Zhang P., Zhang J., Yang S., Liu Y. The effects of lncRNA MALAT1 on proliferation, invasion and migration in colorectal cancer through regulating SOX9. Mol. Med. 2018;24:52.

    Not in our library10.1186/s10020-018-0050-5

17. 17.

    Chen L., Zhang Y.H., Lu G., Huang T., Cai Y.D. Analysis of cancer-related lncRNAs using gene ontology and KEGG pathways. Artif. Intell. Med. 2017;76:27-36.

    Not in our library10.1016/j.artmed.2017.02.001

18. 18.

    Peng F., Wang R., Zhang Y., Zhao Z., Zhou W., Chang Z., Liang H., Zhao W., Qi L., Guo Z., et al. Differential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma. Mol. Cancer. 2017;16:98.

    Not in our library10.1186/s12943-017-0666-z

19. 19.

    Liu M., Zhang H., Li Y., Wang R., Li Y., Zhang H., Ren D., Liu H., Kang C., Chen J. HOTAIR, a long noncoding RNA, is a marker of abnormal cell cycle regulation in lung cancer. Cancer Sci. 2018;109:2717-2733.

    Not in our library10.1111/cas.13745

20. 20.

    Peng K., Liu R., Yu Y., Liang L., Yu S., Xu X., Liu T. Identification and validation of cetuximab resistance associated long noncoding RNA biomarkers in metastatic colorectal cancer. Biomed. Pharmacother. 2018;97:1138-1146.

    Not in our library10.1016/j.biopha.2017.11.031

21. 21.

    Ponting C.P., Oliver P.L., Reik W. Evolution and Functions of Long Noncoding RNAs. Cell. 2009;136:629-641.

    Not in our library10.1016/j.cell.2009.02.006

22. 22.
    Molecular mechanisms of long noncoding RNAs and their role in disease pathogenesis · 2018

    No notice
23. 23.

    Wang K.C., Chang H.Y. Molecular mechanisms of long noncoding RNAs. Mol. Cell. 2011;43:904-914.

    Not in our library10.1016/j.molcel.2011.08.018

24. 24.

    Akhade V.S., Pal D., Kanduri C. Long Noncoding RNA: Genome Organization and Mechanism of Action. Adv. Exp. Med. Biol. 2017;1008:47-74.

    Not in our library10.1007/978-981-10-5203-3_2

25. 25.

    Deans C., Maggert K.A. What Do You Mean, “Epigenetic”? Genetics. 2015;199:887-896.

    Not in our library10.1534/genetics.114.173492

26. 26.

    Peterson C.L., Workman J.L. Promoter targeting and chromatin remodeling by the SWI/SNF complex. Curr. Opin. Genet. Dev. 2000;10:187-192.

    Not in our library10.1016/s0959-437x(00)00068-x

27. 27.

    Wu Q., Lian J.B., Stein J.L., Stein G.S., Nickerson A.J., Imbalzano A.N. The BRG1 ATPase of human SWI/SNF chromatin remodeling enzymes as a driver of cancer. Epigenomics. 2017;9:919-931.

    Not in our library10.2217/epi-2017-0034

28. 28.
    Linking long non-coding RNAs and SWI/SNF complexes to chromatin remodeling in cancer · 2017

    No notice
29. 29.

    Lee R.S., Roberts C.W.M. Linking the SWI/SNF complex to prostate cancer. Nat. Genet. 2013;45:1268-1269.

    Not in our library10.1038/ng.2805

30. 30.

    Chen Z., Gao Y., Yao L., Liu Y., Huang L., Yan Z., Zhao W., Zhu P., Weng H. LncFZD6 initiates Wnt/β-catenin and liver TIC self-renewal through BRG1-mediated FZD6 transcriptional activation. Oncogene. 2018;37:3098-3112.

    Not in our library10.1038/s41388-018-0203-6

31. 31.

    Wang Y., He L., Du Y., Zhu P., Huang G., Luo J., Yan X., Ye B., Li C., Xia P., et al. The Long Noncoding RNA lncTCF7 Promotes Self-Renewal of Human Liver Cancer Stem Cells through Activation of Wnt Signaling. Cell Stem Cell. 2015;16:413-425.

    Not in our library10.1016/j.stem.2015.03.003

32. 32.

    Deng J., Mueller M., Geng T., Shen Y., Liu Y., Hou P., Ramillapalli R., Taylor H.S., Paidas M., Huang Y. H19 lncRNA alters methylation and expression of Hnf4α in the liver of metformin-exposed fetuses. Cell Death Dis. 2017;8:e3175.

    Not in our library10.1038/cddis.2017.392

33. 33.

    Arab K., Park Y.J., Lindroth A.M., Schäfer A., Oakes C., Weichenhan D., Lukanova A., Lundin E., Risch A., Meister M., et al. Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A. Mol. Cell. 2014;55:604-614.

    Not in our library10.1016/j.molcel.2014.06.031

34. 34.

    Jain A.K., Xi Y., McCarthy R., Allton K., Akdemir K.C., Patel L.R., Aronow B., Lin C., Li W., Yang L., et al. LncPRESS1 is a p53-regulated lncRNA that safeguards pluripotency by disrupting SIRT6 mediated de-acetylation of histone H3K56. Mol. Cell. 2016;64:967-981.

    Not in our library10.1016/j.molcel.2016.10.039

35. 35.
    The long noncoding RNA SNHG1 regulates colorectal cancer cell growth through interactions with EZH2 and miR-154-5p · 2018

    No notice
36. 36.

    Terashima M., Tange S., Ishimura A., Suzuki T. MEG3 Long Noncoding RNA Contributes to the Epigenetic Regulation of Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines. J. Biol. Chem. 2017;292:82-99.

    Not in our library10.1074/jbc.m116.750950

37. 37.

    Chiu H.S., Llobet-Navas D., Yang X., Chung W.J., Ambesi-Impiombato A., Iyer A., Kim H.R., Seviour E.G., Luo Z., Sehgal V., et al. Cupid: Simultaneous reconstruction of microRNA-target and ceRNA networks. Genome Res. 2015;25:257-267.

    Not in our library10.1101/gr.178194.114

38. 38.

    Thomson D.W., Dinger M.E. Endogenous microRNA sponges: Evidence and controversy. Nat. Rev. Genet. 2016;17:272-283.

    Not in our library10.1038/nrg.2016.20

39. 39.

    Tam C., Wong J.H., Tsui S.K.W., Zuo T., Chan T.F., Ng T.B. LncRNAs with miRNAs in regulation of gastric, liver, and colorectal cancers: Updates in recent years. Appl. Microbiol. Biotechnol. 2019;103:4649-4677.

    Not in our library10.1007/s00253-019-09837-5

40. 40.

    Zhao Y., Feng C., Li Y., Ma Y., Cai R. LncRNA H19 promotes lung cancer proliferation and metastasis by inhibiting miR-200a function. Mol. Cell. Biochem. 2019;1-8.

    Not in our library10.1007/s11010-019-03564-1

Cited by papers we hold 7

• Blood-derived lncRNAs as biomarkers for cancer diagnosis: the Good, the Bad and the Beauty · 2022
  No notice
• The role of lncRNA-mediated ceRNA regulatory networks in pancreatic cancer · 2022
  No notice
• Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells · 2021
  Not checked
• Construction and Analysis of the Dysregulated ceRNA Network and Identification of Risk Long Noncoding RNAs in Breast Cancer · 2021
  Not checked
• A novel lncRNA ROPM-mediated lipid metabolism governs breast cancer stem cell properties · 2021
  No notice
• ALKBH5-mediated m6A demethylation of lncRNA PVT1 plays an oncogenic role in osteosarcoma · 2020
  No notice
• Sex differences in cancer mechanisms · 2020
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.