No retraction, correction or concern found when last checked on Oct 16, 2026.

Long Non-Coding RNA in the Pathogenesis of Cancers

Yujing Chi, Di Wang, Junpei Wang and 2 more

Cells · 2019 · Review · CC BY

Abstract

The incidence and mortality rate of cancer has been quickly increasing in the past decades. At present, cancer has become the leading cause of death worldwide. Most of the cancers cannot be effectively diagnosed at the early stage. Although there are multiple therapeutic treatments, including surgery, radiotherapy, chemotherapy, and targeted drugs, their effectiveness is still limited. The overall survival rate of malignant cancers is still low. It is necessary to further study the mechanisms for malignant cancers, and explore new biomarkers and targets that are more sensitive and effective for early diagnosis, treatment, and prognosis of cancers than traditional biomarkers and methods. Long non-coding RNAs (lncRNAs) are a class of RNA transcripts with a length greater than 200 nucleotides. Generally, lncRNAs are not capable of encoding proteins or peptides. LncRNAs exert diverse biological functions by regulating gene expressions and functions at transcriptional, translational, and post-translational levels. In the past decade, it has been demonstrated that the dysregulated lncRNA profile is widely involved in the pathogenesis of many diseases, including cancer, metabolic disorders, and cardiovascular diseases. In particular, lncRNAs have been revealed to play an important role in tumor growth and metastasis. Many lncRNAs have been shown to be potential biomarkers and targets for the diagnosis and treatment of cancers. This review aims to briefly discuss the latest findings regarding the roles and mechanisms of some important lncRNAs in the pathogenesis of certain malignant cancers, including lung, breast, liver, and colorectal cancers, as well as hematological malignancies and neuroblastoma.

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Not in our library10.1097/jto.0000000000000470
100.
Deng J., Liang Y., Liu C., He S., Wang S. The up-regulation of long non-coding RNA AFAP1-AS1 is associated with the poor prognosis of NSCLC patients. Biomed. Pharmacother. 2015;75:8-11.
Not in our library10.1016/j.biopha.2015.07.003
101.
Yin D., Lu X., Su J., He X., De W., Yang J., Li W., Han L., Zhang E. Long noncoding RNA AFAP1-AS1 predicts a poor prognosis and regulates non-small cell lung cancer cell proliferation by epigenetically repressing p21 expression. Mol. Cancer. 2018;17:92.
Not in our library10.1186/s12943-018-0836-7
102.
Leng X., Ding X., Wang S., Fang T., Shen W., Xia W., You R., Xu K., Yin R. Long noncoding RNA AFAP1-AS1 is upregulated in NSCLC and associated with lymph node metastasis and poor prognosis. Oncol. Lett. 2018;16:727-732.
Not in our library10.3892/ol.2018.8784
103.
Yu S., Yang D., Ye Y., Liu P., Chen Z., Lei T., Pu J., Liu L., Wang Z. Long noncoding RNA actin filament-associated protein 1 antisense RNA 1 promotes malignant phenotype through binding with lysine-specific demethylase 1 and repressing HMG box-containing protein 1 in non-small-cell lung cancer. Cancer Sci. 2019.
Not in our library10.1111/cas.14039
104.
Peng B., Liu A., Yu X., Xu E., Dai J., Li M., Yang Q. Silencing of lncRNA AFAP1-AS1 suppressed lung cancer development by regulatory mechanism in cis and trans. Oncotarget. 2017;8:93608-93623.
Not in our library10.18632/oncotarget.20549
105.
Tang X.D., Zhang D.D., Jia L., Ji W., Zhao Y.S. lncRNA AFAP1-AS1 Promotes Migration and Invasion of Non-Small Cell Lung Cancer via Up-Regulating IRF7 and the RIG-I-Like Receptor Signaling Pathway. Cell. Physiol. Biochem. 2018;50:179-195.
Not in our library10.1159/000493967
106.
Zeng Z., Bo H., Gong Z., Lian Y., Li X., Li X., Zhang W., Deng H., Zhou M., Peng S., et al. AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis. Tumour. Biol. 2016;37:729-737.
Not in our library10.1007/s13277-015-3860-x
107.
Sui J., Li Y.H., Zhang Y.Q., Shen X., Yao W.Z., Hong W.W., Li C.Y., Peng H., Liang G.Y., Yin L.H., et al. Integrated analysis of long non-coding RNA-associated ceRNA network reveals potential lncRNA biomarkers in human lung adenocarcinoma. Int. J. Oncol. 2016;49:2023-2036.
Not in our library10.3892/ijo.2016.3716
108.
Nagini S. Breast Cancer: Current Molecular Therapeutic Targets and New Players. Anti Cancer Agents Med. Chem. 2017;17:152-163.
Not in our library10.2174/1871520616666160502122724
109.
Collette J., Le Bourhis X., Adriaenssens E. Regulation of Human Breast Cancer by the Long Non-Coding RNA H19. Int. J. Mol. Sci. 2017;18:2319.
Not in our library10.3390/ijms18112319
110.
Rinn J.L., Kertesz M., Wang J.K., Squazzo S.L., Xu X., Brugmann S.A., Goodnough H., Helms J.A., Farnham P.J., Segal E., et al. Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Non-Coding RNAs. Cell. 2007;129:1311-1323.
Not in our library10.1016/j.cell.2007.05.022
111.
Gupta R.A., Shah N., Wang K.C., Kim J., Horlings H.M., Wong D.J., Tsai M.-C., Hung T., Argani P., Rinn J.L., et al. Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature. 2010;464:1071-1076.
Not in our library10.1038/nature08975
112.
Yang Z., Zhou L., Wu L.-M., Lai M.-C., Xie H.-Y., Zhang F., Zheng S.-S. Overexpression of Long Non-coding RNA HOTAIR Predicts Tumor Recurrence in Hepatocellular Carcinoma Patients Following Liver Transplantation. Ann. Surg. Oncol. 2011;18:1243-1250.
Not in our library10.1245/s10434-011-1581-y
113.
Enhanced Expression of Long Non-Coding RNA HOTAIR Is Associated with the Development of Gastric Cancer · 2013
No notice
114.
Yang X., He J., Chang Y., Luo A., Luo A., Zhang J., Zhang R., Xia H., Xu L. HOTAIR gene polymorphisms contribute to increased neuroblastoma susceptibility in Chinese children. Cancer. 2018;124:2599-2606.
Not in our library10.1002/cncr.31353
115.
Zhang L., Song X., Wang X., Xie Y., Wang Z., Xu Y., You X., Liang Z., Cao H. Circulating DNA of HOTAIR in serum is a novel biomarker for breast cancer. Breast Cancer Res. Treat. 2015;152:199-208.
Not in our library10.1007/s10549-015-3431-2
116.
Jiao Z.Y., Tian Q., Li N., Wang H.B., Li K.Z. Plasma long non-coding RNAs (lncRNAs) serve as potential biomarkers for predicting breast cancer. Eur. Rev. Med. Pharmacol. Sci. 2018;22:1994-1999.
Not in our library10.26355/eurrev_201804_14727
117.
Lu R., Zhang J., Zhang W., Huang Y., Wang N., Zhang Q., Qu S., Lv R. Circulating HOTAIR expression predicts the clinical response to neoadjuvant chemotherapy in patients with breast cancer. Cancer Biomark. 2018;22:249-256.
Not in our library10.3233/cbm-170874
118.
Zhang Y., Zhang K., Luo Z., Liu L., Wu L., Liu J. Circulating long non-coding HOX transcript antisense intergenic ribonucleic acid in plasma as a potential biomarker for diagnosis of breast cancer. Thorac. Cancer. 2016;7:627-632.
Not in our library10.1111/1759-7714.12373
119.
Lin Y., Guo W., Li N., Fu F., Lin S., Wang C. Polymorphisms of long non-coding RNA HOTAIR with breast cancer susceptibility and clinical outcomes for a southeast Chinese Han population. Oncotarget. 2018;9:3677-3689.
Not in our library10.18632/oncotarget.23343
120.
Hassanzarei S., Sattarifard H., Ghavami S., Hashemi M., Hashemi S.M., Bahari G. Genetic polymorphisms of HOTAIR gene are associated with the risk of breast cancer in a sample of southeast Iranian population. Tumor Biol. 2017;39:1010428317727539.
Not in our library10.1177/1010428317727539
121.
Jiang Y., Du F., Chen F., Qin N., Jiang Z., Zhou J., Jiang T., Pu Z., Cheng Y., Chen J., et al. Potentially functional variants in lncRNAs are associated with breast cancer risk in a Chinese population. Mol. Carcinog. 2017;56:2048-2057.
Not in our library10.1002/mc.22659
122.
Tang S., Zheng K., Tang Y., Li Z., Zou T., Liu D. Overexpression of serum exosomal HOTAIR is correlated with poor survival and poor response to chemotherapy in breast cancer patients. J. Biosci. 2019;44:37.
Not in our library10.1007/s12038-019-9861-y
123.
Wang Y.L., Liu L.C., Hung Y., Chen C.J., Lin Y.Z., Wu W.R., Wang S.C. Long non-coding RNA HOTAIR in circulatory exosomes is correlated with ErbB2/HER2 positivity in breast cancer. Breast. 2019;46:64-69.
Not in our library10.1016/j.breast.2019.05.003
124.
Bhan A., Hussain I., Ansari K.I., Kasiri S., Bashyal A., Mandal S.S. Antisense-transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol. J. Mol. Biol. 2013;425:3707-3722.
Not in our library10.1016/j.jmb.2013.01.022
125.
Tao S., He H., Chen Q. Estradiol induces HOTAIR levels via GPER-mediated miR-148a inhibition in breast cancer. J. Transl. Med. 2015;13:131.
Not in our library10.1186/s12967-015-0489-x
126.
Xue X., Yang Y.A., Zhang A., Fong K.W., Kim J., Song B., Li S., Zhao J.C., Yu J. LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer. Oncogene. 2016;35:2746-2755.
Not in our library10.1038/onc.2015.340
127.
Sørensen K.P., Thomassen M., Tan Q., Bak M., Cold S., Burton M., Larsen M.J., Kruse T.A. Long non-coding RNA HOTAIR is an independent prognostic marker of metastasis in estrogen receptor-positive primary breast cancer. Breast Cancer Res. Treat. 2013;142:529-536.
Not in our library10.1007/s10549-013-2776-7
128.
Gökmen-Polar Y., Vladislav I.T., Neelamraju Y., Janga S.C., Badve S. Prognostic Impact of HOTAIR Expression is Restricted to ER-Negative Breast Cancers. Sci. Rep. 2015;5:8765.
Not in our library10.1038/srep08765
129.
Yu Y., Lv F., Liang D., Yang Q., Zhang B., Lin H., Wang X., Qian G., Xu J., You W. HOTAIR may regulate proliferation, apoptosis, migration and invasion of MCF-7 cells through regulating the P53/Akt/JNK signaling pathway. Biomed. Pharmacother. 2017;90:555-561.
Not in our library10.1016/j.biopha.2017.03.054
130.
Lnc RNA HOTAIR influences cell growth, migration, invasion, and apoptosis via the miR‐20a‐5p/ HMGA 2 axis in breast cancer · 2018
Retracted
131.
Bae I.H., Park M.J., Yoon S.H., Kang S.W., Lee S.S., Choi K.M., Um H.D. Bcl-w Promotes Gastric Cancer Cell Invasion by Inducing Matrix Metalloproteinase-2 Expression via Phosphoinositide 3-Kinase, Akt, and Sp1. Cancer Res. 2006;66:4991-4995.
Not in our library10.1158/0008-5472.can-05-4254
132.
Kim E.M., Kim J., Park J.K., Hwang S.G., Kim W.J., Lee W.J., Kang S.W., Um H.D. Bcl-w promotes cell invasion by blocking the invasion-suppressing action of Bax. Cell. Signal. 2012;24:1163-1172.
Not in our library10.1016/j.cellsig.2012.01.019
133.
Ding W., Ren J., Ren H., Wang D. Long Noncoding RNA HOTAIR Modulates MiR-206-mediated Bcl-w Signaling to Facilitate Cell Proliferation in Breast Cancer. Sci. Rep. 2017;7:17261.
Not in our library10.1038/s41598-017-17492-x
134.
Liu L.C., Wang Y.L., Lin P.L., Zhang X., Cheng W.C., Liu S.H., Chen C.J., Hung Y., Jan C.I., Chang L.C., et al. Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15. Int. J. Cancer. 2019.
Not in our library10.1002/ijc.32319
135.
Alves C.P., Fonseca A.S., Muys B.R., Bueno R.D.B.E.L., Bürger M.C., De Souza J.E.S., Valente V., Zago M.A., Silva W.A. Brief Report: The lincRNA Hotair Is Required for Epithelial-to-Mesenchymal Transition and Stemness Maintenance of Cancer Cell Lines. Stem Cells. 2013;31:2827-2832.
Not in our library10.1002/stem.1547
136.
Long Non-Coding RNA HOTAIR Regulates the Proliferation, Self-Renewal Capacity, Tumor Formation and Migration of the Cancer Stem-Like Cell (CSC) Subpopulation Enriched from Breast Cancer Cells. · 2017
Not checked
137.
Zhang H., Cai K., Wang J., Wang X., Cheng K., Shi F., Jiang L., Zhang Y., Dou J. MiR-7, Inhibited Indirectly by LincRNA HOTAIR, Directly Inhibits SETDB1 and Reverses the EMT of Breast Cancer Stem Cells by Downregulating the STAT3 Pathway. STEM CELLS. 2014;32:2858-2868.
Not in our library10.1002/stem.1795
138.
Bhan A., Hussain I., Ansari K.I., Bobzean S.A.M., Perrotti L.I., Mandal S.S. Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo. J. Steroid Biochem. Mol. Biol. 2014;141:160-170.
Not in our library10.1016/j.jsbmb.2014.02.002
139.
Schneider C., King R.M., Philipson L. Genes specifically expressed at growth arrest of mammalian cells. Cell. 1988;54:787-793.
Not in our library10.1016/s0092-8674(88)91065-3
140.
Coccia E.M., Cicala C., Charlesworth A., Ciccarelli C., Rossi G.B., Philipson L., Sorrentino V. Regulation and expression of a growth arrest-specific gene (gas5) during growth, differentiation, and development. Mol. Cell. Biol. 1992;12:3514-3521.
Not in our library10.1128/mcb.12.8.3514
141.
The long non-coding RNA, GAS5, enhances gefitinib-induced cell death in innate EGFR tyrosine kinase inhibitor-resistant lung adenocarcinoma cells with wide-type EGFR via downregulation of the IGF-1R expression · 2015
No notice
142.
Tu Z.Q., Li R.J., Mei J.Z., Li X.H. Down-regulation of long non-coding RNA GAS5 is associated with the prognosis of hepatocellular carcinoma. Int. J. Clin. Exp. Pathol. 2014;7:4303-4309.
Not in our library
143.
Yin D., He X., Zhang E., Kong R., De W., Zhang Z. Long noncoding RNA GAS5 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer. Med. Oncol. 2014;31:253.
Not in our library10.1007/s12032-014-0253-8
144.
Downregulation of LncRNA GAS5 causes trastuzumab resistance in breast cancer · 2016
No notice
145.
Zong Y., Zhang Y., Sun X., Xu T., Cheng X., Qin Y. miR-221/222 promote tumor growth and suppress apoptosis by targeting lncRNA GAS5 in breast cancer. Biosci. Rep. 2019;39:39.
Not in our library10.1042/bsr20181859
146.
Gu J., Wang Y., Wang X., Zhou D., Wang X., Zhou M., He Z. Effect of the LncRNA GAS5-MiR-23a-ATG3 Axis in Regulating Autophagy in Patients with Breast Cancer. Cell. Physiol. Biochem. 2018;48:194-207.
Not in our library10.1159/000491718
147.
Arshi A., Sharifi F.S., Ghahfarokhi M.K., Faghih Z., Doosti A., Ostovari S., Maymand E.M., Seno M.M.G. Expression Analysis of MALAT1, GAS5, SRA, and NEAT1 lncRNAs in Breast Cancer Tissues from Young Women and Women over 45 Years of Age. Mol. Ther. Nucleic Acids. 2018;12:751-757.
Not in our library10.1016/j.omtn.2018.07.014
148.
Han L., Ma P., Liu S.M., Zhou X. Circulating long noncoding RNA GAS5 as a potential biomarker in breast cancer for assessing the surgical effects. Tumour. Biol. 2016;37:6847-6854.
Not in our library10.1007/s13277-015-4568-7
149.
Koldemir O., Özgür E., Gezer U. Accumulation of GAS5 in exosomes is a marker of apoptosis induction. Biomed. Rep. 2017;6:358-362.
Not in our library10.3892/br.2017.848
150.
Tang Y., Wang Y., Wang X., Liu Y., Zheng K. A Genetic Variant of rs145204276 in the Promoter Region of Long Noncoding RNA GAS5 Is Associated with a Reduced Risk of Breast Cancer. Clin. Breast Cancer. 2018.
Not in our library10.1016/j.clbc.2018.11.006
151.
Liu H.Y., Zhang Y.Y., Zhu B.L., Feng F.Z., Yan H., Zhang H.Y., Zhou B. miR-21 regulates the proliferation and apoptosis of ovarian cancer cells through PTEN/PI3K/AKT. Eur. Rev. Med. Pharmacol. Sci. 2019;23:4149-4155.
Not in our library10.26355/eurrev_201905_17917
152.
MiR-21 and MiR-155 promote non-small cell lung cancer progression by downregulating SOCS1 , SOCS6 , and PTEN · 2016
No notice
153.
Yang C.H., Pfeffer S.R., Sims M., Yue J., Wang Y., Linga V.G., Paulus E., Davidoff A.M., Pfeffer L.M. The Oncogenic MicroRNA-21 Inhibits the Tumor Suppressive Activity of FBXO11 to Promote Tumorigenesis. J. Biol. Chem. 2015;290:6037-6046.
Not in our library10.1074/jbc.m114.632125
154.
Zhang Z., Zhu Z., Watabe K., Zhang X., Bai C., Xu M., Wu F., Mo Y.Y. Negative regulation of lncRNA GAS5 by miR-21. Cell Death Differ. 2013;20:1558-1568.
Not in our library10.1038/cdd.2013.110
155.
Li S., Zhou J., Wang Z., Wang P., Gao X., Wang Y. Long noncoding RNA GAS5 suppresses triple negative breast cancer progression through inhibition of proliferation and invasion by competitively binding miR-196a-5p. Biomed. Pharmacother. 2018;104:451-457.
Not in our library10.1016/j.biopha.2018.05.056
156.
Narayan M., Wilken J.A., Harris L.N., Baron A.T., Kimbler K.D., Maihle N.J. Trastuzumab-Induced HER Reprogramming in “Resistant” Breast Carcinoma Cells. Cancer Res. 2009;69:2191-2194.
Not in our library10.1158/0008-5472.can-08-1056
157.
Gu J., Wang Y., Wang X., Zhou D., Shao C., Zhou M., He Z. Downregulation of lncRNA GAS5 confers tamoxifen resistance by activating miR-222 in breast cancer. Cancer Lett. 2018;434:1-10.
Not in our library10.1016/j.canlet.2018.06.039
158.
Pickard M.R., Williams G.T. Regulation of apoptosis by long non-coding RNA GAS5 in breast cancer cells: Implications for chemotherapy. Breast Cancer Res. Treat. 2014;145:359-370.
Not in our library10.1007/s10549-014-2974-y
159.
Zhang K., Luo Z., Zhang Y., Zhang L., Wu L., Liu L., Yang J., Song X., Liu J. Circulating lncRNA H19 in plasma as a novel biomarker for breast cancer. Cancer Biomark. 2016;17:187-194.
Not in our library10.3233/cbm-160630
160.
Si H., Chen P., Li H., Wang X. Long non-coding RNA H19 regulates cell growth and metastasis via miR-138 in breast cancer. Am. J. Transl. Res. 2019;11:3213-3225.
Not in our library
161.
H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b · 2015
No notice
162.
Sun H., Wang G., Peng Y., Zeng Y., Zhu Q.N., Li T.L., Cai J.Q., Zhou H.H., Zhu Y.S. H19 lncRNA mediates 17β-estradiol-induced cell proliferation in MCF-7 breast cancer cells. Oncol. Rep. 2015;33:3045-3052.
Not in our library10.3892/or.2015.3899
163.
Xia Z., Yan R., Duan F., Song C., Wang P., Wang K. Genetic Polymorphisms in Long Noncoding RNA H19 Are Associated with Susceptibility to Breast Cancer in Chinese Population. Medicine (Baltimore). 2016;95:e2771.
Not in our library10.1097/md.0000000000002771
164.
Lin Y., Fu F., Chen Y., Qiu W., Lin S., Yang P., Huang M., Wang C. Genetic variants in long noncoding RNA H19 contribute to the risk of breast cancer in a southeast China Han population. Onco Targets Ther. 2017;10:4369-4378.
Not in our library10.2147/ott.s127962
165.
Cui P., Zhao Y., Chu X., He N., Zheng H., Han J., Song F., Chen K. SNP rs2071095 in LincRNA H19 is associated with breast cancer risk. Breast Cancer Res. Treat. 2018;171:161-171.
Not in our library10.1007/s10549-018-4814-y
166.
Safari M.R., Rezaei F.M., Dehghan A., Noroozi R., Taheri M., Ghafouri-Fard S. Genomic variants within the long non-coding RNA H19 confer risk of breast cancer in Iranian population. Gene. 2019;701:121-124.
Not in our library10.1016/j.gene.2019.03.036
167.
Abdollahzadeh S., Ghorbian S. Association of the study between LncRNA-H19 gene polymorphisms with the risk of breast cancer. J. Clin. Lab. Anal. 2019;33:e22826.
Not in our library10.1002/jcla.22826
168.
Li Z., Li Y., Li Y., Ren K., Li X., Han X., Wang J. Long non-coding RNA H19 promotes the proliferation and invasion of breast cancer through upregulating DNMT1 expression by sponging miR-152. J. Biochem. Mol. Toxicol. 2017;31.
Not in our library10.1002/jbt.21933
169.
Zhou W., Ye X.L., Xu J., Cao M.G., Fang Z.Y., Li L.Y., Guan G.H., Liu Q., Qian Y.H., Xie D. The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b. Sci. Signal. 2017;10:eaak9557.
Not in our library10.1126/scisignal.aak9557
170.
Wang N., Hou M., Zhan Y., Sheng X. LncRNA PTCSC3 inhibits triple-negative breast cancer cell proliferation by downregulating lncRNA H19. J. Cell. Biochem. 2019.
Not in our library10.1002/jcb.28769
171.
H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance · 2017
Corrected
172.
Han J., Han B., Wu X., Hao J., Dong X., Shen Q., Pang H. Knockdown of lncRNA H19 restores chemo-sensitivity in paclitaxel-resistant triple-negative breast cancer through triggering apoptosis and regulating Akt signaling pathway. Toxicol. Appl. Pharmacol. 2018;359:55-61.
Not in our library10.1016/j.taap.2018.09.018
173.
LncRNA H19 confers chemoresistance in ERα-positive breast cancer through epigenetic silencing of the pro-apoptotic gene BIK · 2016
No notice
174.
Involvement of CUL4A in Regulation of Multidrug Resistance to P-gp Substrate Drugs in Breast Cancer Cells · 2013
Not checked
175.
Zhu Q.N., Wang G., Guo Y., Peng Y., Zhang R., Deng J.L., Li Z.X., Zhu Y.S. LncRNA H19 is a major mediator of doxorubicin chemoresistance in breast cancer cells through a cullin4A-MDR1 pathway. Oncotarget. 2017;8:91990-92003.
Not in our library10.18632/oncotarget.21121
176.
Basak P., Chatterjee S., Bhat V., Su A., Jin H., Lee-Wing V., Liu Q., Hu P., Murphy L.C., Raouf A. Long Non-Coding RNA H19 Acts as an Estrogen Receptor Modulator that is Required for Endocrine Therapy Resistance in ER+Breast Cancer Cells. Cell. Physiol. Biochem. 2018;51:1518-1532.
Not in our library10.1159/000495643
177.
Gao H., Hao G., Sun Y., Li L., Wang Y. Long noncoding RNA H19 mediated the chemosensitivity of breast cancer cells via Wnt pathway and EMT process. Onco Targets Ther. 2018;11:8001-8012.
Not in our library10.2147/ott.s172379
178.
Chen S., Zhu J., Wang F., Guan Z., Ge Y., Yang X., Cai J. LncRNAs and their role in cancer stem cells. Oncotarget. 2017;8:110685-110692.
Not in our library10.18632/oncotarget.22161
179.
Liu F.T., Dong Q., Gao H., Zhu Z.M. The prognostic significance of UCA1 for predicting clinical outcome in patients with digestive system malignancies. Oncotarget. 2017;8:40620-40632.
Not in our library10.18632/oncotarget.16534
180.
Wang X.S., Zhang Z., Cai J.L., Xu Q.W., Li M.Q., Chen Y.C., Qian X.P., Lu T.J., Yu L.Z., Xin D.Q., et al. Rapid Identification of UCA1 as a Very Sensitive and Specific Unique Marker for Human Bladder Carcinoma. Clin. Cancer Res. 2006;12:4851-4858.
Not in our library10.1158/1078-0432.ccr-06-0134
181.
LncRNA—UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p · 2016
No notice
182.
Li Z., Yu D., Li H., Lv Y., Li S. Long non-coding RNA UCA1 confers tamoxifen resistance in breast cancer endocrinotherapy through regulation of the EZH2/p21 axis and the PI3K/AKT signaling pathway. Int. J. Oncol. 2019;54:1033-1042.
Not in our library10.3892/ijo.2019.4679
183.
Li G.Y., Wang W., Sun J.Y., Xin B., Zhang X., Wang T., Zhang Q.F., Yao L.B., Han H., Fan D.M., et al. Long non-coding RNAs AC026904.1 and UCA1: A “one-two punch” for TGF-β-induced SNAI2 activation and epithelial-mesenchymal transition in breast cancer. Theranostics. 2018;8:2846-2861.
Not in our library10.7150/thno.23463
184.
Liu H., Wang G., Yang L., Qu J., Yang Z., Zhou X. Knockdown of Long Non-Coding RNA UCA1 Increases the Tamoxifen Sensitivity of Breast Cancer Cells through Inhibition of Wnt/β-Catenin Pathway. PLoS ONE. 2016;11:e0168406.
Not in our library10.1371/journal.pone.0168406
185.
Liu M., Xing L.Q., Liu Y.J. A three-long noncoding RNA signature as a diagnostic biomarker for differentiating between triple-negative and non-triple-negative breast cancers. Medicine (Baltimore). 2017;96:e6222.
Not in our library10.1097/md.0000000000006222
186.
Han S., Park K., Kim H., Lee M., Kim H., Kim Y. Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation. Breast Cancer Res. Treat. 1999;55:159-165.
Not in our library10.1023/a:1006258222233
187.
Huang J., Zhou N., Watabe K., Lu Z., Wu F., Xu M., Mo Y.Y. Long non-coding RNA UCA1 promotes breast tumor growth by suppression of p27 (Kip1). Cell Death Dis. 2014;5:e1008.
Not in our library10.1038/cddis.2013.541
188.
Tuo Y.L., Li X.M., Luo J. Long noncoding RNA UCA1 modulates breast cancer cell growth and apoptosis through decreasing tumor suppressive miR-143. Eur. Rev. Med. Pharmacol. Sci. 2015;19:3403-3411.
Not in our library
189.
Chen S., Shao C., Xu M., Ji J., Xie Y., Lei Y., Wang X. Macrophage infiltration promotes invasiveness of breast cancer cells via activating long non-coding RNA UCA1. Int. J. Clin. Exp. Pathol. 2015;8:9052-9061.
Not in our library
190.
Hajra K.M., Chen D.Y.S., Fearon E.R. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 2002;62:1613-1618.
Not in our library
191.
Xiao C., Wu C.H., Hu H.Z. LncRNA UCA1 promotes epithelial-mesenchymal transition (EMT) of breast cancer cells via enhancing Wnt/beta-catenin signaling pathway. Eur. Rev. Med. Pharmacol. Sci. 2016;20:2819-2824.
Not in our library
192.
Early Breast Cancer Trialists’ Collaborative G. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials. Lancet. 2005;365:1687-1717.
Not in our library10.1016/s0140-6736(05)66544-0
193.
Wu C., Luo J. Long Non-Coding RNA (lncRNA) Urothelial Carcinoma-Associated 1 (UCA1) Enhances Tamoxifen Resistance in Breast Cancer Cells via Inhibiting mTOR Signaling Pathway. Med. Sci. Monit. 2016;22:3860-3867.
Not in our library10.12659/msm.900689
194.
Li X., Wu Y., Liu A., Tang X. Long non-coding RNA UCA1 enhances tamoxifen resistance in breast cancer cells through a miR-18a-HIF1α feedback regulatory loop. Tumor Biol. 2016;37:14733-14743.
Not in our library10.1007/s13277-016-5348-8
195.
Xu C.G., Yang M.F., Ren Y.Q., Wu C.H., Wang L.Q. Exosomes mediated transfer of lncRNA UCA1 results in increased tamoxifen resistance in breast cancer cells. Eur. Rev. Med. Pharmacol. Sci. 2016;20:4362-4368.
Not in our library
196.
Zhu H.Y., Bai W.D., Ye X.M., Yang A.G., Jia L.T. Long non-coding RNA UCA1 desensitizes breast cancer cells to trastuzumab by impeding miR-18a repression of Yes-associated protein. Biochem. Biophys. Res. Commun. 2018;496:1308-1313.
Not in our library10.1016/j.bbrc.2018.02.006
197.
Loewer S., Cabili M.N., Guttman M., Loh Y.H., Thomas K., Park I.H., Garber M., Curran M., Onder T., Agarwal S., et al. Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Nat. Genet. 2010;42:1113-1117.
Not in our library10.1038/ng.710
198.
Amaral P.P., Clark M.B., Gascoigne D.K., Dinger M.E., Mattick J.S. lncRNAdb: A reference database for long noncoding RNAs. Nucleic Acids Res. 2011;39:D146-D151.
Not in our library10.1093/nar/gkq1138
199.
Zhang K., Luo Z., Zhang Y., Wang Y., Cui M., Liu L., Zhang L., Liu J. Detection and analysis of circulating large intergenic non-coding RNA regulator of reprogramming in plasma for breast cancer. Thorac. Cancer. 2018;9:66-74.
Not in our library10.1111/1759-7714.12537
200.
Chen Y.M., Liu Y., Wei H.Y., Lv K.Z., Fu P. Linc-ROR induces epithelial-mesenchymal transition and contributes to drug resistance and invasion of breast cancer cells. Tumor Biol. 2016;37:10861-10870.
Not in our library10.1007/s13277-016-4909-1
201.
Eades G., Wolfson B., Zhang Y., Li Q., Yao Y., Zhou Q. lincRNA-RoR and miR-145 regulate invasion in triple-negative breast cancer via targeting ARF6. Mol. Cancer Res. 2015;13:330-338.
Not in our library10.1158/1541-7786.mcr-14-0251
202.
Ma J., Yang Y., Huo D., Wang Z., Zhai X., Chen J., Sun H., An W., Jie J., Yang P. LincRNA-RoR/miR-145 promote invasion and metastasis in triple-negative breast cancer via targeting MUC1. Biochem. Biophys. Res. Commun. 2018;500:614-620.
Not in our library10.1016/j.bbrc.2018.04.119
203.
Lu P.W., Li L., Wang F., Gu Y.T. Inhibitory role of large intergenic noncoding RNA-ROR on tamoxifen resistance in the endocrine therapy of breast cancer by regulating the PI3K/Akt/mTOR signaling pathway. J. Cell. Physiol. 2019;234:1904-1912.
Not in our library10.1002/jcp.27066
204.
Hou P., Zhao Y., Li Z., Yao R., Ma M., Gao Y., Zhao L., Zhang Y., Huang B., Lü J. LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis. Cell Death Dis. 2014;5:e1287.
Not in our library10.1038/cddis.2014.249
205.
Duru N., Gernapudi R., Lo P.K., Yao Y., Wolfson B., Zhang Y., Zhou Q. Characterization of the CD49f+/CD44+/CD24- single-cell derived stem cell population in basal-like DCIS cells. Oncotarget. 2016;7:47511-47525.
Not in our library10.18632/oncotarget.10203
206.
Marengo A., Rosso C., Bugianesi E. Liver Cancer: Connections with Obesity, Fatty Liver, and Cirrhosis. Annu. Rev. Med. 2016;67:103-117.
Not in our library10.1146/annurev-med-090514-013832
207.
lncRNA involvement in hepatocellular carcinoma metastasis and prognosis · 2018
No notice
208.
Li C.H., Chen Y. Targeting long non-coding RNAs in cancers: Progress and prospects. Int. J. Biochem. Cell Biol. 2013;45:1895-1910.
Not in our library10.1016/j.biocel.2013.05.030
209.
Ishibashi M., Kogo R., Shibata K., Sawada G., Takahashi Y., Kurashige J., Akiyoshi S., Sasaki S., Iwaya T., Sudo T., et al. Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma. Oncol. Rep. 2013;29:946-950.
Not in our library10.3892/or.2012.2219
210.
Geng Y.J., Xie S.L., Li Q., Ma J., Wang G.Y. Large intervening non-coding RNA HOTAIR is associated with hepatocellular carcinoma progression. J. Int. Med. Res. 2011;39:2119-2128.
Not in our library10.1177/147323001103900608
211.
Gao J.Z., Li J., Du J.L., Li X.L. Long non-coding RNA HOTAIR is a marker for hepatocellular carcinoma progression and tumor recurrence. Oncol. Lett. 2016;11:1791-1798.
Not in our library10.3892/ol.2016.4130
212.
Zhang J., Liu L., Lin Z., Ji X., Pi L., Lin X., Tian N., Liu G., Liu Q., Lin Z., et al. SNP-SNP and SNP-environment interactions of potentially functional HOTAIR SNPs modify the risk of hepatocellular carcinoma. Mol. Carcinog. 2019;58:633-642.
Not in our library10.1002/mc.22955
213.
Long Non-Coding RNA HOTAIR Promotes Cell Migration and Invasion via Down-Regulation of RNA Binding Motif Protein 38 in Hepatocellular Carcinoma Cells · 2014
No notice
214.
Zhou J.J., Cheng D., He X.Y., Meng Z., Li W.Z., Chen R.F. Knockdown of Hotair suppresses proliferation and cell cycle progression in hepatocellular carcinoma cell by downregulating CCND1 expression. Mol. Med. Rep. 2017;16:4980-4986.
Not in our library10.3892/mmr.2017.7162
215.
Yang L., Zhang X., Li H.Y., Liu J. The long noncoding RNA HOTAIR activates autophagy by upregulating ATG3 and ATG7 in hepatocellular carcinoma. Mol. BioSyst. 2016;12:2605-2612.
Not in our library10.1039/c6mb00114a
216.
Ye P., Wang T., Liu W.H., Li X.C., Tang L.J., Tian F.Z., Li X.C. Enhancing HOTAIR/MiR-10b Drives Normal Liver Stem Cells Toward a Tendency to Malignant Transformation Through Inducing Epithelial- to-Mesenchymal Transition. Rejuvenation Res. 2015;18:332-340.
Not in our library10.1089/rej.2014.1642
217.
LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2 · 2015
No notice
218.
Yang T., He X., Chen A., Tan K., Du X. LncRNA HOTAIR contributes to the malignancy of hepatocellular carcinoma by enhancing epithelial-mesenchymal transition via sponging miR-23b-3p from ZEB1. Gene. 2018;670:114-122.
Not in our library10.1016/j.gene.2018.05.061
219.
Au S.L.K., Wong C.C.L., Lee J.M.F., Fan D.N.Y., Tsang F.H., Ng I.O.L., Wong C.M. Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis. Hepatology. 2012;56:622-631.
Not in our library10.1002/hep.25679
220.
Fu W.M., Zhu X., Wang W.M., Lu Y.F., Hu B.G., Wang H., Liang W.C., Wang S.S., Ko C.H., Waye M.M.Y., et al. Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling. J. Hepatol. 2015;63:886-895.
Not in our library10.1016/j.jhep.2015.05.016
221.
Cheng D., Deng J., Zhang B., He X., Meng Z., Li G., Ye H., Zheng S., Wei L., Deng X., et al. LncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation. EBioMedicine. 2018;36:159-170.
Not in our library10.1016/j.ebiom.2018.08.055
222.
Kong J., Qiu Y., Li Y., Zhang H., Wang W. TGF-β1 elevates P-gp and BCRP in hepatocellular carcinoma through HOTAIR/miR-145 axis. Biopharm. Drug Dispos. 2019;40:70-80.
Not in our library10.1002/bdd.2172
223.
Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma · 2019
No notice
224.
Panzitt K., Tschernatsch M.M., Guelly C., Moustafa T., Stradner M., Strohmaier H.M., Buck C.R., Denk H., Schroeder R., Trauner M., et al. Characterization of HULC, a Novel Gene with Striking Up-Regulation in Hepatocellular Carcinoma, as Noncoding RNA. Gastroenterology. 2007;132:330-342.
Not in our library10.1053/j.gastro.2006.08.026
225.
LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 signaling pathway · 2016
No notice
226.
Yang Z., Lu Y., Xu Q., Tang B., Park C.-K., Chen X. HULC and H19 Played Different Roles in Overall and Disease-Free Survival from Hepatocellular Carcinoma after Curative Hepatectomy: A Preliminary Analysis from Gene Expression Omnibus. Dis. Markers. 2015;2015:1-9.
Not in our library10.1155/2015/191029
227.
Plasma HULC as a Promising Novel Biomarker for the Detection of Hepatocellular Carcinoma · 2013
No notice
228.
Li J., Wang X., Tang J., Jiang R., Zhang W., Ji J., Sun B. HULC and Linc00152 Act as Novel Biomarkers in Predicting Diagnosis of Hepatocellular Carcinoma. Cell. Physiol. Biochem. 2015;37:687-696.
Not in our library10.1159/000430387
229.
Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a · 2018
No notice
230.
Wan D., Shen S., Fu S., Preston B., Brandon C., He S., Shen C., Wu J., Wang S., Xie W., et al. miR-203 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting oncogene ADAM9 and oncogenic long non-coding RNA HULC. Anti Cancer Agents Med. Chem. 2016;16:414-423.
Not in our library10.2174/1871520615666150716105955
231.
Hu D., Shen D., Zhang M., Jiang N., Sun F., Yuan S., Wan K. MiR-488 suppresses cell proliferation and invasion by targeting ADAM9 and lncRNA HULC in hepatocellular carcinoma. Am. J. Cancer Res. 2017;7:2070-2080.
Not in our library
232.
Wang J., Liu X., Wu H., Ni P., Gu Z., Qiao Y., Chen N., Sun F., Fan Q. CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res. 2010;38:5366-5383.
Not in our library10.1093/nar/gkq285
233.
Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1) · 2015
No notice
234.
Du Y., Kong G., You X., Zhang S., Zhang T., Gao Y., Ye L., Zhang X. Elevation of Highly Up-regulated in Liver Cancer (HULC) by Hepatitis B Virus X Protein Promotes Hepatoma Cell Proliferation via Down-regulating p18. J. Biol. Chem. 2012;287:26302-26311.
Not in our library10.1074/jbc.m112.342113
235.
Jiang Z., Liu H. Metformin inhibits tumorigenesis in HBV-induced hepatocellular carcinoma by suppressing HULC overexpression caused by HBX. J. Cell. Biochem. 2018;119:4482-4495.
Not in our library10.1002/jcb.26555
236.
Liu Y., Feng J., Sun M., Yang G., Yuan H., Wang Y., Bu Y., Zhao M., Zhang S., Zhang X. Long non-coding RNA HULC activates HBV by modulating HBx/STAT3/miR-539/APOBEC3B signaling in HBV-related hepatocellular carcinoma. Cancer Lett. 2019;454:158-170.
Not in our library10.1016/j.canlet.2019.04.008
237.
A Genetic Variant in Long Non-Coding RNA HULC Contributes to Risk of HBV-Related Hepatocellular Carcinoma in a Chinese Population · 2012
No notice
238.
Zhang Q., Chen C.Y., Yedavalli V.S.R.K., Jeang K.T. NEAT1 Long Noncoding RNA and Paraspeckle Bodies Modulate HIV-1 Posttranscriptional Expression. mBio. 2013;4:e00596-12.
Not in our library10.1128/mbio.00596-12
239.
Guo S., Chen W., Luo Y., Ren F., Zhong T., Rong M., Dang Y., Feng Z., Chen G. Clinical implication of long non-coding RNA NEAT1 expression in hepatocellular carcinoma patients. Int. J. Clin. Exp. Pathol. 2015;8:5395-5402.
Not in our library
240.
Liu Z., Chang Q., Yang F., Liu B., Yao H.W., Bai Z.G., Pu C.S., Ma X.M., Yang Y., Wang T.T., et al. Long non-coding RNA NEAT1 overexpression is associated with unfavorable prognosis in patients with hepatocellular carcinoma after hepatectomy: A Chinese population-based study. Eur. J. Surg. Oncol. 2017;43:1697-1703.
Not in our library10.1016/j.ejso.2017.06.013
241.
Shaker O.G., Ayoub S.E., Abdelwahed M.Y., Ahmed N.A., Hassan E.A., Ahmed T.I., Abousarie M.A. Evaluation of serum long noncoding RNA NEAT and MiR-129-5p in hepatocellular carcinoma. IUBMB Life. 2019.
Not in our library10.1002/iub.2096
242.
Fujimoto A., Furuta M., Totoki Y., Tsunoda T., Kato M., Shiraishi Y., Tanaka H., Taniguchi H., Kawakami Y., Ueno M., et al. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nat. Genet. 2016;48:500-509.
Not in our library10.1038/ng.3547
243.
Ling Z.A., Xiong D.D., Meng R.M., Cen J.M., Zhao N., Chen G., Li R.L., Dang Y.W. LncRNA NEAT1 Promotes Deterioration of Hepatocellular Carcinoma Based on In Vitro Experiments, Data Mining, and RT-qPCR Analysis. Cell. Physiol. Biochem. 2018;48:540-555.
Not in our library10.1159/000491811
244.
Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation · 2018
No notice
245.
Zhou J., Lu X.J., Zhang X.N., Zhang X.N., Zhang X., Wang C. The long noncoding RNA NEAT1 contributes to hepatocellular carcinoma development by sponging miR-485 and enhancing the expression of the STAT3. J. Cell. Physiol. 2018;233:6733-6741.
Not in our library10.1002/jcp.26371
246.
Zhu L., Yang N., Li C., Liu G., Pan W., Li X. Long noncoding RNA NEAT1 promotes cell proliferation, migration, and invasion in hepatocellular carcinoma through interacting with miR-384. J. Cell. Biochem. 2018.
Not in our library10.1002/jcb.27499
247.
Zheng X., Zhang Y., Liu Y., Fang L., Li L., Sun J., Pan Z., Xin W., Huang P. HIF-2alpha activated lncRNA NEAT1 promotes hepatocellular carcinoma cell invasion and metastasis by affecting the epithelial-mesenchymal transition. J. Cell. Biochem. 2018;119:3247-3256.
Not in our library10.1002/jcb.26481
248.
Yang X., Qu S., Wang L., Zhang H., Yang Z., Wang J., Dai B., Tao K., Shang R., Liu Z., et al. PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612. Oncogene. 2018;37:6399-6413.
Not in our library10.1038/s41388-018-0416-8
249.
Wang S., Zhang Q., Wang Q., Shen Q., Chen X., Li Z., Zhou Y., Hou J., Xu B., Li N., et al. NEAT1 paraspeckle promotes human hepatocellular carcinoma progression by strengthening IL-6/STAT3 signaling. OncoImmunology. 2018;7:e1503913.
Not in our library10.1080/2162402x.2018.1503913
250.
Chen X., Zhang N. Downregulation of lncRNA NEAT1_2 radiosensitizes hepatocellular carcinoma cells through regulation of miR-101-3p/WEE1 axis. Cell Biol. Int. 2019;43:44-55.
Not in our library10.1002/cbin.11077
251.
Chen S., Xia X. Long noncoding RNA NEAT1 suppresses sorafenib sensitivity of hepatocellular carcinoma cells via regulating miR-335–c-Met. J. Cell. Physiol. 2019;234:14999-15009.
Not in our library10.1002/jcp.27567
252.
Yan K., Fu Y., Zhu N., Wang Z., Hong J.L., Li Y., Li W.J., Zhang H.B., Song J.H. Repression of lncRNA NEAT1 enhances the antitumor activity of CD8(+)T cells against hepatocellular carcinoma via regulating miR-155/Tim-3. Int. J. Biochem. Cell Biol. 2019;110:1-8.
Not in our library10.1016/j.biocel.2019.01.019
253.
Zhang M., Wang W., Li T., Yu X., Zhu Y., Ding F., Li D., Yang T. Long noncoding RNA SNHG1 predicts a poor prognosis and promotes hepatocellular carcinoma tumorigenesis. Biomed. Pharmacother. 2016;80:73-79.
Not in our library10.1016/j.biopha.2016.02.036
254.
Gao S., Xu X., Wang Y., Zhang W., Wang X. Diagnostic utility of plasma lncRNA small nucleolar RNA host gene 1 in patients with hepatocellular carcinoma. Mol. Med. Rep. 2018;18:3305-3313.
Not in our library10.3892/mmr.2018.9336
255.
Xiao B., Huang Z., Zhou R., Zhang J., Yu B. The Prognostic Value of Expression of the Long Noncoding RNA (lncRNA) Small Nucleolar RNA Host Gene 1 (SNHG1) in Patients with Solid Malignant Tumors: A Systematic Review and Meta-Analysis. Med. Sci. Monit. 2018;24:5462-5472.
Not in our library10.12659/msm.911687
256.
Tan C., Cao J., Chen L., Xi X., Wang S., Zhu Y., Yang L., Ma L., Wang D., Yin J., et al. Noncoding RNAs Serve as Diagnosis and Prognosis Biomarkers for Hepatocellular Carcinoma. Clin. Chem. 2019;65:905-915.
Not in our library10.1373/clinchem.2018.301150
257.
Zhang H., Zhou D., Ying M., Chen M., Chen P., Chen Z., Zhang F. Expression of Long Non-Coding RNA (lncRNA) Small Nucleolar RNA Host Gene 1 (SNHG1) Exacerbates Hepatocellular Carcinoma Through Suppressing miR-195. Med. Sci. Monit. 2016;22:4820-4829.
Not in our library10.12659/msm.898574
258.
LncRNA SNHG1 contributes to sorafenib resistance by activating the Akt pathway and is positively regulated by miR-21 in hepatocellular carcinoma cells · 2019
Corrected
259.
Riley T., Sontag E., Chen P., Levine A. Transcriptional control of human p53-regulated genes. Nat. Rev. Mol. Cell Biol. 2008;9:402-412.
Not in our library10.1038/nrm2395
260.
Huarte M., Guttman M., Feldser D., Garber M., Koziol M.J., Kenzelmann-Broz D., Khalil A.M., Zuk O., Amit I., Rabani M., et al. A large intergenic non-coding RNA induced by p53 mediates global gene repression in the p53 response. Cell. 2010;142:409-419.
Not in our library10.1016/j.cell.2010.06.040
261.
Yu F., Zhou G., Huang K., Fan X., Li G., Chen B., Dong P., Zheng J. Serum lincRNA-p21 as a potential biomarker of liver fibrosis in chronic hepatitis B patients. J. Viral Hepat. 2017;24:580-588.
Not in our library10.1111/jvh.12680
262.
Yang N., Fu Y., Zhang H., Sima H., Zhu N., Yang G. LincRNA-p21 activates endoplasmic reticulum stress and inhibits hepatocellular carcinoma. Oncotarget. 2015;6:28151-28163.
Not in our library10.18632/oncotarget.4661
263.
Wang S., Jiang J., Zhang C., Zhang X., Wang C. Serum lincRNA-p21 expression in primary liver diseases and liver metastatic diseases. Pathol. Res. Pract. 2019;215:779-783.
Not in our library10.1016/j.prp.2019.01.014
264.
Zheng J., Dong P., Mao Y., Chen S., Wu X., Li G., Lu Z., Yu F. lincRNA-p21 inhibits hepatic stellate cell activation and liver fibrogenesis via p21. FEBS J. 2015;282:4810-4821.
Not in our library10.1111/febs.13544
265.
Ding G., Peng Z., Shang J., Kang Y., Ning H., Mao C. LincRNA-p21 inhibits invasion and metastasis of hepatocellular carcinoma through miR-9/E-cadherin cascade signaling pathway molecular mechanism. Onco Targets Ther. 2017;10:3241-3247.
Not in our library10.2147/ott.s134910
266.
Jia M., Jiang L., Wang Y., Huang J., Yu M., Xue H. LincRNA -p21 inhibits invasion and metastasis of hepatocellular carcinoma through Notch signaling induced epithelial-mesenchymal transition. Hepatol. Res. 2016;46:1137-1144.
Not in our library10.1111/hepr.12659
267.
Kam Y., Rubinstein A., Naik S., Djavsarov I., Halle D., Ariel I., Güre A.O., Stojadinovic A., Pan H., Tsivin V., et al. Detection of a long non-coding RNA (CCAT1) in living cells and human adenocarcinoma of colon tissues using FIT–PNA molecular beacons. Cancer Lett. 2014;352:90-96.
Not in our library10.1016/j.canlet.2013.02.014
268.
Mobley L.R., Kuo T.M. Demographic Disparities in Late-Stage Diagnosis of Breast and Colorectal Cancers Across the USA. J. Racial Ethn. Health Disparities. 2017;4:201-212.
Not in our library10.1007/s40615-016-0219-y
269.
Andriulli A., Loperfido S., Napolitano G., Niro G., Valvano M.R., Spirito F., Pilotto A., Forlano R. Incidence Rates of Post-ERCP Complications: A Systematic Survey of Prospective Studies. Am. J. Gastroenterol. 2007;102:1781-1788.
Not in our library10.1111/j.1572-0241.2007.01279.x
270.
Long J., Yin Y., Guo H., Li S., Sun Y., Zeng C., Zhu W. The mechanisms and clinical significance of PDCD4 in colorectal cancer. Gene. 2019;680:59-64.
Not in our library10.1016/j.gene.2018.09.034
271.
Issa A.I., Noureddine M. Colorectal cancer screening: An updated review of the available options. World J. Gastroenterol. 2017;23:5086-5096.
Not in our library10.3748/wjg.v23.i28.5086
272.
Chen S.T., Lee T.Y., Tsai T.H., Huang Y.C., Lin Y.C., Lin C.P., Shieh H.R., Hsu M.L., Chi C.W., Lee M.C., et al. Traditional Chinese medicine Danggui Buxue Tang inhibits colorectal cancer growth through induction of autophagic cell death. Oncotarget. 2017;8:88563-88574.
Not in our library10.18632/oncotarget.19902
273.
Xin Y., Li Z., Shen J., Chan M.T.V., Wu W.K.K. CCAT1: A pivotal oncogenic long non-coding RNA in human cancers. Cell Prolif. 2016;49:255-260.
Not in our library10.1111/cpr.12252
274.
Nissan A., Stojadinovic A., Mitrani-Rosenbaum S., Halle D., Grinbaum R., Roistacher M., Bochem A., Dayanc B.E., Ritter G., Gomceli I., et al. Colon cancer associated transcript-1: A novel RNA expressed in malignant and pre-malignant human tissues. Int. J. Cancer. 2012;130:1598-1606.
Not in our library10.1002/ijc.26170
275.
Wang N., Yu Y., Xu B., Zhang M., Li Q., Miao L. Pivotal prognostic and diagnostic role of the long noncoding RNA colon cancerassociated transcript 1 expression in human cancer (Review). Mol. Med. Rep. 2019;19:771-782.
Not in our library10.3892/mmr.2018.9721
276.
Guo X., Hua Y. CCAT1: An oncogenic long noncoding RNA in human cancers. J. Cancer Res. Clin. Oncol. 2017;143:555-562.
Not in our library10.1007/s00432-016-2268-3
277.
Differential expression of colon cancer associated transcript1 (CCAT1) along the colonic adenoma-carcinoma sequence · 2013
No notice
278.
Ye Z., Zhou M., Tian B., Wu B., Li J. Expression of lncRNA-CCAT1, E-cadherin and N-cadherin in colorectal cancer and its clinical significance. Int. J. Clin. Exp. Med. 2015;8:3707-3715.
Not in our library
279.
Ozawa T., Matsuyama T., Toiyama Y., Takahashi N., Ishikawa T., Uetake H., Yamada Y., Kusunoki M., Calin G., Goel A. CCAT1 and CCAT2 long noncoding RNAs, located within the 8q.24.21 ‘gene desert’, serve as important prognostic biomarkers in colorectal cancer. Ann. Oncol. 2017;28:1882-1888.
Not in our library10.1093/annonc/mdx248
280.
Jing F., Jin H., Mao Y., Fan C., Ding Y., Li Y., Chen K. Genome-wide analysis of long non-coding RNA expression and function in colorectal cancer. Tumor Biol. 2017;39:1010428317703650.
Not in our library10.1177/1010428317703650
281.
LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions · 2018
No notice
282.
Zhao W., Song M., Zhang J., Kuerban M., Wang H. Combined identification of long non-coding RNA CCAT1 and HOTAIR in serum as an effective screening for colorectal carcinoma. Int. J. Clin. Exp. Pathol. 2015;8:14131-14140.
Not in our library
283.
Li Y., Jing F., Ding Y., He Q., Zhong Y., Fan C. Long noncoding RNA CCAT1 polymorphisms are associated with the risk of colorectal cancer. Cancer Genet. 2018;13-19.
Not in our library10.1016/j.cancergen.2018.02.003
284.
He X., Tan X., Wang X., Jin H., Liu L., Ma L., Yu H., Fan Z. C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion. Tumor Biol. 2014;35:12181-12188.
Not in our library10.1007/s13277-014-2526-4
285.
Kim T., Cui R., Jeon Y.J., Lee J.H., Lee J.H., Sim H., Park J.K., Fadda P., Tili E., Nakanishi H., et al. Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5. Proc. Natl. Acad. Sci. USA. 2014;111:4173-4178.
Not in our library10.1073/pnas.1400350111
286.
Xiang J.F., Yin Q.F., Chen T., Zhang Y., Zhang X.O., Wu Z., Zhang S., Wang H.B., Ge J., Lu X., et al. Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus. Cell Res. 2014;24:513-531.
Not in our library10.1038/cr.2014.35
287.
McCleland M.L., Mesh K., Lorenzana E., Chopra V.S., Segal E., Watanabe C., Haley B., Mayba O., Yaylaoglu M., Gnad F., et al. CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J. Clin. Investig. 2016;126:639-652.
Not in our library10.1172/jci83265
288.
Xin Y., Li Z., Zheng H., Chan M.T., Wu W.K.K. CCAT2: A novel oncogenic long non-coding RNA in human cancers. Cell Prolif. 2017;50:e12342.
Not in our library10.1111/cpr.12342
289.
Foßelteder J., Calin G.A., Pichler M. Long non-coding RNA CCAT2 as a therapeutic target in colorectal cancer. Expert Opin. Ther. Targets. 2018;22:973-976.
Not in our library10.1080/14728222.2018.1541453
290.
Chen S., Wu H., Lv N., Wang H., Wang Y., Tang Q., Shao H., Sun C. LncRNA CCAT2 predicts poor prognosis and regulates growth and metastasis in small cell lung cancer. Biomed. Pharmacother. 2016;82:583-588.
Not in our library10.1016/j.biopha.2016.05.017
291.
Ling H., Spizzo R., Atlasi Y., Nicoloso M., Shimizu M., Redis R.S., Nishida N., Gafà R., Song J., Guo Z., et al. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res. 2013;23:1446-1461.
Not in our library10.1101/gr.152942.112
292.
Zhang J., Jiang Y., Zhu J., Wu T., Ma J., Du C., Chen S., Li T., Han J., Wang X. Overexpression of long non-coding RNA colon cancer-associated transcript 2 is associated with advanced tumor progression and poor prognosis in patients with colorectal cancer. Oncol. Lett. 2017;14:6907-6914.
Not in our library10.3892/ol.2017.7049
293.
A novel mechanism of lncRNA and miRNA interaction: CCAT2 regulates miR-145 expression by suppressing its maturation process in colon cancer cells · 2017
No notice
294.
Wang L., Duan W., Yan S., Xie Y., Wang C. Circulating long non-coding RNA colon cancer-associated transcript 2 protected by exosome as a potential biomarker for colorectal cancer. Biomed. Pharmacother. 2019;113:108758.
Not in our library10.1016/j.biopha.2019.108758
295.
Shaker O.G., Senousy M.A., Elbaz E.M. Association of rs6983267 at 8q24, HULC rs7763881 polymorphisms and serum lncRNAs CCAT2 and HULC with colorectal cancer in Egyptian patients. Sci. Rep. 2017;7:16246.
Not in our library10.1038/s41598-017-16500-4
296.
Dai M., Li S., Qin X. Colorectal neoplasia differentially expressed: A long noncoding RNA with an imperative role in cancer. Onco Targets Ther. 2018;11:3755-3763.
Not in our library10.2147/ott.s162754
297.
Graham L.D., Pedersen S.K., Brown G.S., Ho T., Kassir Z., Moynihan A.T., Vizgoft E.K., Dunne R., Pimlott L., Young G.P., et al. Colorectal Neoplasia Differentially Expressed (CRNDE), a Novel Gene with Elevated Expression in Colorectal Adenomas and Adenocarcinomas. Genes Cancer. 2011;2:829-840.
Not in our library10.1177/1947601911431081
298.
Liang C., Zhang B., Ge H., Xu Y., Li G., Wu J. Long non-coding RNA CRNDE as a potential prognostic biomarker in solid tumors: A meta-analysis. Clin. Chim. Acta. 2018;481:99-107.
Not in our library10.1016/j.cca.2018.02.039
299.
Gao H., Song X., Kang T., Yan B., Feng L., Gao L., Ai L., Liu X., Yu J., Li H. Long noncoding RNA CRNDE functions as a competing endogenous RNA to promote metastasis and oxaliplatin resistance by sponging miR-136 in colorectal cancer. Onco Targets Ther. 2017;10:205-216.
Not in our library10.2147/ott.s116178
300.
Yu B., Ye X., Du Q., Zhu B., Zhai Q. The Long Non-Coding RNA CRNDE Promotes Colorectal Carcinoma Progression by Competitively Binding miR-217 with TCF7L2 and Enhancing the Wnt/β-Catenin Signaling Pathway. Cell. Physiol. Biochem. 2017;41:2489-2502.
Not in our library10.1159/000475941
301.
Long noncoding RNA CRNDE promotes colorectal cancer cell proliferation via epigenetically silencing DUSP5/CDKN1A expression · 2017
No notice
302.
Jiang H., Wang Y., Ai M., Wang H., Duan Z., Wang H., Zhao L., Yu J., Ding Y., Wang S. Long noncoding RNA CRNDE stabilized by hnRNPUL2 accelerates cell proliferation and migration in colorectal carcinoma via activating Ras/MAPK signaling pathways. Cell Death Dis. 2017;8:e2862.
Not in our library10.1038/cddis.2017.258
303.
Kim T., Croce C.M. Long noncoding RNAs: Undeciphered cellular codes encrypting keys of colorectal cancer pathogenesis. Cancer Lett. 2018;417:89-95.
Not in our library10.1016/j.canlet.2017.12.033
304.
The lncRNA CRNDE promotes colorectal cancer cell proliferation and chemoresistance via miR-181a-5p-mediated regulation of Wnt/β-catenin signaling · 2017
No notice
305.
Cui M., Chen M., Shen Z., Wang R., Fang X., Song B. LncRNA-UCA1 modulates progression of colon cancer through regulating the miR-28-5p/HOXB3 axis. J. Cell. Biochem. 2019;120:6926-6936.
Not in our library10.1002/jcb.27630
306.
Hong H.H., Hou L.K., Pan X., Wu C.Y., Huang H., Li B., Nie W. Long non-coding RNA UCA1 is a predictive biomarker of cancer. Oncotarget. 2016;7:44442-44447.
Not in our library10.18632/oncotarget.10142
307.
Wang Y.H., Wang F., Zhang L., Lu J.C. Long non-coding RNA UCA1 can predict tumor lymph node metastasis. Tumor Biol. 2017;39:1010428317706208.
Not in our library10.1177/1010428317706208
308.
Gharib E., Anaraki F., Baghdar K., Ghavidel P., Sadeghi H., Nasrabadi P.N., Peyravian N., Aghdaei H.A., Zali M.R., Mojarad E.N. Investigating the diagnostic performance of HOTTIP, PVT1, and UCA1 long noncoding RNAs as a predictive panel for the screening of colorectal cancer patients with lymph node metastasis. J. Cell. Biochem. 2019;120:14780-14790.
Not in our library10.1002/jcb.28739
309.
Predictive role of UCA1-containing exosomes in cetuximab-resistant colorectal cancer · 2018
Not checked
310.
Song F., Li L., Liang D., Zhuo Y., Wang X., Dai H. Knockdown of long noncoding RNA urothelial carcinoma associated 1 inhibits colorectal cancer cell proliferation and promotes apoptosis via modulating autophagy. J. Cell. Physiol. 2019;234:7420-7434.
Not in our library10.1002/jcp.27500
311.
Jahangiri B., Khalaj-Kondori M., Asadollahi E., Sadeghizadeh M. Cancer-associated fibroblasts enhance cell proliferation and metastasis of colorectal cancer SW480 cells by provoking long noncoding RNA UCA1. J. Cell Commun. Signal. 2019;13:53-64.
Not in our library10.1007/s12079-018-0471-5
312.
Taylor J., Xiao W., Abdel-Wahab O. Diagnosis and classification of hematologic malignancies on the basis of genetics. Blood. 2017;130:410-423.
Not in our library10.1182/blood-2017-02-734541
313.
Romero-Campero F.J., Perez-Hurtado I., Lucas-Reina E., Romero J.M., Valverde F. ChlamyNET: A Chlamydomonas gene co-expression network reveals global properties of the transcriptome and the early setup of key co-expression patterns in the green lineage. BMC Genom. 2016;17:227.
Not in our library10.1186/s12864-016-2564-y
314.
Nobili L., Lionetti M., Neri A. Long non-coding RNAs in normal and malignant hematopoiesis. Oncotarget. 2016;7:50666-50681.
Not in our library10.18632/oncotarget.9308
315.
Izadifard M., Pashaiefar H., Yaghmaie M., Montazeri M., Sadraie M., Momeny M., Jalili M., Ahmadvand M., Ghaffari S.H., Mohammadi S., et al. Expression Analysis of PVT1, CCDC26, and CCAT1 Long Noncoding RNAs in Acute Myeloid Leukemia Patients. Genet. Test. Mol. Biomark. 2018;22:593-598.
Not in our library10.1089/gtmb.2018.0143
316.
Houshmand M., Yazdi N., Kazemi A., Atashi A., Hamidieh A.A., Najemdini A.A., Pour M.M., Zarif M.N. Long non-coding RNA PVT1 as a novel candidate for targeted therapy in hematologic malignancies. Int. J. Biochem. Cell Biol. 2018;98:54-64.
Not in our library10.1016/j.biocel.2018.03.001
317.
Nagoshi H., Taki T., Hanamura I., Nitta M., Otsuki T., Nishida K., Okuda K., Sakamoto N., Kobayashi S., Yamamoto-Sugitani M., et al. Frequent PVT1 Rearrangement and Novel Chimeric Genes PVT1-NBEA and PVT1-WWOX Occur in Multiple Myeloma with 8q24 Abnormality. Cancer Res. 2012;72:4954-4962.
Not in our library10.1158/0008-5472.can-12-0213
318.
PVT1: A Rising Star among Oncogenic Long Noncoding RNAs · 2015
No notice
319.
Tsutsumi Y., Chinen Y., Sakamoto N., Nagoshi H., Nishida K., Kobayashi S., Yokokawa Y., Taki T., Sasaki N., Yamamoto-Sugitani M., et al. Deletion or methylation of CDKN2A/2B and PVT1 rearrangement occur frequently in highly aggressive B-cell lymphomas harboring 8q24 abnormality. Leuk. Lymphoma. 2013;54:2760-2764.
Not in our library10.3109/10428194.2013.790543
320.
Zhuang C., Li J., Liu Y., Chen M., Yuan J., Fu X., Zhan Y., Liu L., Lin J., Zhou Q., et al. Tetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells. Oncotarget. 2015;6:41194-41203.
Not in our library10.18632/oncotarget.5880
321.
Ding J., Li D., Gong M., Wang J., Huang X., Wu T., Wang C. Expression and clinical significance of the long non-coding RNA PVT1 in human gastric cancer. OncoTargets Ther. 2014;7:1625-1630.
Not in our library10.2147/ott.s68854
322.
Takahashi Y., Sawada G., Kurashige J., Uchi R., Matsumura T., Ueo H., Takano Y., Eguchi H., Sudo T., Sugimachi K., et al. Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers. Br. J. Cancer. 2014;110:164-171.
Not in our library10.1038/bjc.2013.698
323.
Guan Y., Kuo W.L., Stilwell J.L., Takano H., Lapuk A.V., Fridlyand J., Mao J.H., Yu M., Miller M.A., Santos J.L., et al. Amplification of PVT1 Contributes to the Pathophysiology of Ovarian and Breast Cancer. Clin. Cancer Res. 2007;13:5745-5755.
Not in our library10.1158/1078-0432.ccr-06-2882
324.
Song J., Wu X., Liu F., Li M., Sun Y., Wang Y., Wang C., Zhu K., Jia X., Wang B., et al. Long non-coding RNA PVT1 promotes glycolysis and tumor progression by regulating miR-497/HK2 axis in osteosarcoma. Biochem. Biophys. Res. Commun. 2017;490:217-224.
Not in our library10.1016/j.bbrc.2017.06.024
325.
Cui D., Yu C.H., Liu M., Xia Q.Q., Zhang Y.F., Jiang W.L. Long non-coding RNA PVT1 as a novel biomarker for diagnosis and prognosis of non-small cell lung cancer. Tumour Biol. 2016;37:4127-4134.
Not in our library10.1007/s13277-015-4261-x
326.
Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16 · 2015
No notice
327.
Yang J.P., Yang X.J., Xiao L., Wang Y. Long noncoding RNA PVT1 as a novel serum biomarker for detection of cervical cancer. Eur. Rev. Med. Pharmacol. Sci. 2016;20:3980-3986.
Not in our library
328.
Zeng C., Yu X., Lai J., Yang L., Chen S., Li Y. Overexpression of the long non-coding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia. J. Hematol. Oncol. 2015;8:126.
Not in our library10.1186/s13045-015-0223-4
329.
Yang M., Zhang L., Wang X., Zhou Y., Wu S. Down-regulation of miR-203a by lncRNA PVT1 in multiple myeloma promotes cell proliferation. Arch. Med. Sci. 2018;14:1333-1339.
Not in our library10.5114/aoms.2018.73975
330.
Salehi M., Sharifi M. Induction of apoptosis and necrosis in human acute erythroleukemia cells by inhibition of long non-coding RNA PVT1. Mol. Biol. Res. Commun. 2018;7:89-96.
Not in our library10.22099/mbrc.2018.29081.1316
331.
Yazdi N., Houshmand M., Atashi A., Kazemi A., Najmedini A.A., Zarif M.N. Long noncoding RNA PVT1: Potential oncogene in the development of acute lymphoblastic leukemia. Turk. J. Biol. 2018;42:405-413.
Not in our library10.3906/biy-1801-46
332.
Lee S., Luo W., Shah T., Yin C., O’Connell T., Chung T.-H., Perkins S.L., Miles R.R., Ayello J., Morris E., et al. The effects of DLEU1 gene expression in Burkitt lymphoma (BL): Potential mechanism of chemoimmunotherapy resistance in BL. Oncotarget. 2017;8:27839-27853.
Not in our library10.18632/oncotarget.15711
333.
Garitano-Trojaola A., Agirre X., Prósper F., Fortes P. Long Non-Coding RNAs in Haematological Malignancies. Int. J. Mol. Sci. 2013;14:15386-15422.
Not in our library10.3390/ijms140815386
334.
Guo Y., Bai M., Lin L., Huang J., An Y., Liang L., Liu Y., Huang W. LncRNA DLEU2 aggravates the progression of hepatocellular carcinoma through binding to EZH2. Biomed. Pharmacother. 2019;118:109272.
Not in our library10.1016/j.biopha.2019.109272
335.
LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3 · 2018
No notice
336.
Xie Z.Z., Xiao Z.C., Song Y.X., Li W., Tan G.L. Long non-coding RNA Dleu2 affects proliferation, migration and invasion ability of laryngeal carcinoma cells through triggering miR-16-1 pathway. Eur. Rev. Med. Pharmacol. Sci. 2018;22:1963-1970.
Not in our library10.26355/eurrev_201804_14723
337.
Xu B., Gong X., Zi L., Li G., Dong S., Chen X., Li Y. Silencing of DLEU2 suppresses pancreatic cancer cell proliferation and invasion by upregulating microRNA-445. Cancer Sci. 2019;110:1676-1685.
Not in our library10.1111/cas.13987
338.
Wang L., Sun K., Wu D., Xiu Y., Chen X., Chen S., Zong Z., Sang X., Liu Y., Zhao Y. DLEU1 contributes to ovarian carcinoma tumourigenesis and development by interacting with miR-490-3p and altering CDK1 expression. J. Cell. Mol. Med. 2017;21:3055-3065.
Not in our library10.1111/jcmm.13217
339.
Nava-Rodríguez M.P., Domínguez-Cruz M.D., Aguilar-López L.B., Borjas-Gutiérrez C., Magaña-Torres M.T., González-García J.R. Genomic instability in a chronic lymphocytic leukemia patient with mono-allelic deletion of the DLEU and RB1 genes. Mol. Cytogenet. 2019;12:2.
Not in our library10.1186/s13039-019-0417-5
340.
Ronchetti D., Agnelli L., Taiana E., Galletti S., Manzoni M., Todoerti K., Musto P., Strozzi F., Neri A. Distinct lncRNA transcriptional fingerprints characterize progressive stages of multiple myeloma. Oncotarget. 2016;7:14814-14830.
Not in our library10.18632/oncotarget.7442
341.
Lerner M., Harada M., Lovén J., Castro J., Davis Z., Oscier D., Henriksson M., Sangfelt O., Grandér D., Corcoran M.M. DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1. Exp. Cell Res. 2009;315:2941-2952.
Not in our library10.1016/j.yexcr.2009.07.001
342.
Morenos L., Chatterton Z., Ng J.L., Halemba M.S., Parkinson-Bates M., Méchinaud F., Elwood N., Saffery R., Wong N.C. Hypermethylation and down-regulation of DLEU2 in paediatric acute myeloid leukaemia independent of embedded tumour suppressor miR-15a/16-1. Mol. Cancer. 2014;13:123.
Not in our library10.1186/1476-4598-13-123
343.
Klein U., Lia M., Crespo M., Siegel R., Shen Q., Mo T., Ambesi-Impiombato A., Califano A., Migliazza A., Bhagat G., et al. The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia. Cancer Cell. 2010;17:28-40.
Not in our library10.1016/j.ccr.2009.11.019
344.
Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a Gene Cluster That Targets NF-kB · 2013
No notice
345.
Lyu Y., Lou J., Yang Y., Feng J., Hao Y., Huang S., Yin L., Xu J., Huang D., Ma B., et al. Dysfunction of the WT1-MEG3 signaling promotes AML leukemogenesis via p53-dependent and -independent pathways. Leukemia. 2017;31:2543-2551.
Not in our library10.1038/leu.2017.116
346.
Yao H., Duan M., Lin L., Wu C., Fu X., Wang H., Guo L., Chen W., Huang L., Liu D., et al. TET2 and MEG3 promoter methylation is associated with acute myeloid leukemia in a Hainan population. Oncotarget. 2017;8:18337-18347.
Not in our library10.18632/oncotarget.15440
347.
Sellers Z.P., Bolkun L., Kloczko J., Wojtaszewska M.L., Lewandowski K., Moniuszko M., Ratajczak M.Z., Schneider G. Increased methylation upstream of the MEG3 promotor is observed in acute myeloid leukemia patients with better overall survival. Clin. Epigenetics. 2019;11:50.
Not in our library10.1186/s13148-019-0643-z
348.
Li Z.Y., Yang L., Liu X.J., Wang X.Z., Pan Y.X., Luo J.M. The Long Noncoding RNA MEG3 and its Target miR-147 Regulate JAK/STAT Pathway in Advanced Chronic Myeloid Leukemia. EBioMedicine. 2018;34:61-75.
Not in our library10.1016/j.ebiom.2018.07.013
349.
Handa H., Kuroda Y., Kimura K., Masuda Y., Hattori H., Alkebsi L., Matsumoto M., Kasamatsu T., Kobayashi N., Tahara K.I., et al. Long non-coding RNA MALAT1 is an inducible stress response gene associated with extramedullary spread and poor prognosis of multiple myeloma. Br. J. Haematol. 2017;179:449-460.
Not in our library10.1111/bjh.14882
350.
MALAT1 long non-coding RNA is overexpressed in multiple myeloma and may serve as a marker to predict disease progression · 2014
No notice
351.
Ahmadi A., Kaviani S., Yaghmaie M., Pashaiefar H., Ahmadvand M., Jalili M., Alimoghaddam K., Eslamijouybari M., Ghavamzadeh A. Altered expression of MALAT1 lncRNA in chronic lymphocytic leukemia patients, correlation with cytogenetic findings. Blood Res. 2018;53:320-324.
Not in our library10.5045/br.2018.53.4.320
352.
Gao D., Lv A.E., Li H.P., Han D.H., Zhang Y.P., Xiao Z., Li H., Han D., Zhang Y. LncRNA MALAT-1 Elevates HMGB1 to Promote Autophagy Resulting in Inhibition of Tumor Cell Apoptosis in Multiple Myeloma. J. Cell. Biochem. 2017;118:3341-3348.
Not in our library10.1002/jcb.25987
353.
Gu Y., Xiao X., Yang S. LncRNA MALAT1 acts as an oncogene in multiple myeloma through sponging miR-509-5p to modulate FOXP1 expression. Oncotarget. 2017;8:101984-101993.
Not in our library10.18632/oncotarget.21957
354.
Hu Y., Lin J., Fang H., Fang J., Li C., Chen W., Liu S., Ondrejka S., Gong Z., Reu F., et al. Targeting the MALAT1/PARP1/LIG3 complex induces DNA damage and apoptosis in multiple myeloma. Leukemia. 2018;32:2250-2262.
Not in our library10.1038/s41375-018-0104-2
355.
Gao D., Xiao Z., Li H.P., Han D.H., Zhang Y.P. The mechanism study of miR-125b in occurrence and progression of multiple myeloma. Cancer Med. 2018;7:134-145.
Not in our library10.1002/cam4.1181
356.
Li L.J., Chai Y., Guo X.J., Chu S.L., Zhang L.S. The effects of the long non-coding RNA MALAT-1 regulated autophagy-related signaling pathway on chemotherapy resistance in diffuse large B-cell lymphoma. Biomed. Pharmacother. 2017;89:939-948.
Not in our library10.1016/j.biopha.2017.02.011
357.
Wang X., Sehgal L., Jain N., Khashab T., Mathur R., Samaniego F. LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2. J. Transl. Med. 2016;14:346.
Not in our library10.1186/s12967-016-1100-9
358.
Yan Y., Han J., Li Z., Yang H., Sui Y., Wang M. Elevated RNA expression of long non-coding HOTAIR promotes cell proliferation and predicts a poor prognosis in patients with diffuse large B cell lymphoma. Mol. Med. Rep. 2016;13:5125-5131.
Not in our library10.3892/mmr.2016.5190
359.
Hao S., Shao Z. HOTAIR is upregulated in acute myeloid leukemia and that indicates a poor prognosis. Int. J. Clin. Exp. Pathol. 2015;8:7223-7228.
Not in our library
360.
Wu S., Zheng C., Chen S., Cai X., Shi Y., Lin B., Chen Y. Overexpression of long non-coding RNA HOTAIR predicts a poor prognosis in patients with acute myeloid leukemia. Oncol. Lett. 2015;10:2410-2414.
Not in our library10.3892/ol.2015.3552
361.
Wang S.L., Huang Y., Su R., Yu Y.Y. Silencing long non-coding RNA HOTAIR exerts anti-oncogenic effect on human acute myeloid leukemia via demethylation of HOXA5 by inhibiting Dnmt3b. Cancer Cell Int. 2019;19:114.
Not in our library10.1186/s12935-019-0808-z
362.
Zhang Y.Y., Huang S.H., Zhou H.R., Chen C.J., Tian L.H., Shen J.Z. Role of HOTAIR in the diagnosis and prognosis of acute leukemia. Oncol. Rep. 2016;36:3113-3122.
Not in our library10.3892/or.2016.5147
363.
Li Z., Luo J. Epigenetic regulation of HOTAIR in advanced chronic myeloid leukemia. Cancer Manag. Res. 2018;10:5349-5362.
Not in our library10.2147/cmar.s166859
364.
Wang H., Li Q., Tang S., Li M., Feng A., Qin L., Liu Z., Wang X. The role of long noncoding RNA HOTAIR in the acquired multidrug resistance to imatinib in chronic myeloid leukemia cells. Hematology. 2017;22:208-216.
Not in our library10.1080/10245332.2016.1258152
365.
Brodeur G.M. Neuroblastoma: Biological insights into a clinical enigma. Nat. Rev. Cancer. 2003;3:203-216.
Not in our library10.1038/nrc1014
366.
Maris J.M., Hogarty M.D., Bagatell R., Cohn S.L. Neuroblastoma. Lancet. 2007;369:2106-2120.
Not in our library10.1016/s0140-6736(07)60983-0
367.
Tomolonis J.A., Agarwal S., Shohet J.M. Neuroblastoma pathogenesis: Deregulation of embryonic neural crest development. Cell Tissue Res. 2018;372:245-262.
Not in our library10.1007/s00441-017-2747-0
368.
Ahmed A.A., Zhang L., Reddivalla N., Hetherington M. Neuroblastoma in children: Update on clinicopathologic and genetic prognostic factors. Pediatr. Hematol. Oncol. 2017;34:165-185.
Not in our library10.1080/08880018.2017.1330375
369.
The rs2147578 C > G polymorphism in the Inc-LAMC2–1:1 gene is associated with increased neuroblastoma risk in the Henan children · 2018
Not checked
370.
Zhang Z., Chang Y., Jia W., Zhang J., Zhang R., Zhu J., Yang T., Xia H., Zou Y., He J. LINC00673 rs11655237 C>T confers neuroblastoma susceptibility in Chinese population. Biosci. Rep. 2018;38:38.
Not in our library10.1042/bsr20171667
371.
Li Y., Zhuo Z.J., Zhou H., Liu J., Liu Z., Zhang J., Cheng J., Li S., Zhou H., Zhou R., et al. Additional data support the role of LINC00673 rs11655237 C>T in the development of neuroblastoma. Aging. 2019;11:2369-2377.
Not in our library10.18632/aging.101920
372.
Tee A.E., Liu B., Song R., Li J., Pasquier E., Cheung B.B., Jiang C., Marshall G.M., Haber M., Norris M.D., et al. The long noncoding RNA MALAT1 promotes tumor-driven angiogenesis by up-regulating pro-angiogenic gene expression. Oncotarget. 2016;7:8663-8675.
Not in our library10.18632/oncotarget.6675
373.
Chen L., Feng P., Zhu X., He S., Duan J., Zhou D. Long non-coding RNA Malat1 promotes neurite outgrowth through activation of ERK/MAPK signalling pathway in N2a cells. J. Cell. Mol. Med. 2016;20:2102-2110.
Not in our library10.1111/jcmm.12904
374.
Tee A.E., Ling D., Nelson C., Atmadibrata B., Dinger M.E., Xu N., Mizukami T., Liu P.Y., Liu B., Cheung B., et al. The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1. Oncotarget. 2014;5:1793-1804.
Not in our library10.18632/oncotarget.1785
375.
Chi R., Chen X., Liu M., Zhang H., Li F., Fan X., Wang W., Lu H. Role of SNHG7-miR-653-5p-STAT2 feedback loop in regulating neuroblastoma progression. J. Cell. Physiol. 2019;234:13403-13412.
Not in our library10.1002/jcp.28017
376.
Sahu D., Hsu C.L., Lin C.C., Yang T.W., Hsu W.M., Ho S.Y., Juan H.F., Huang H.C. Co-expression analysis identifies long noncoding RNA SNHG1 as a novel predictor for event-free survival in neuroblastoma. Oncotarget. 2016;7:58022-58037.
Not in our library10.18632/oncotarget.11158
377.
Yu Y., Chen F., Yang Y., Jin Y., Shi J., Han S., Chu P., Lu J., Tai J., Wang S., et al. lncRNA SNHG16 is associated with proliferation and poor prognosis of pediatric neuroblastoma. Int. J. Oncol. 2019;55:93-102.
Not in our library10.3892/ijo.2019.4813
378.
Chen Y., Lian Y.J., Ma Y.Q., Wu C.J., Zheng Y.K., Xie N.C. LncRNA SNHG1 promotes α-synuclein aggregation and toxicity by targeting miR-15b-5p to activate SIAH1 in human neuroblastoma SH-SY5Y cells. NeuroToxicology. 2018;68:212-221.
Not in our library10.1016/j.neuro.2017.12.001
379.
Mondal T., Juvvuna P.K., Kirkeby A., Mitra S., Kosalai S.T., Traxler L., Hertwig F., Wernig-Zorc S., Miranda C., Deland L., et al. Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis. Cancer Cell. 2018;33:417-434.e7.
Not in our library10.1016/j.ccell.2018.01.020
380.
Russell M.R., Penikis A., Oldridge D.A., Alvarez-Dominguez J.R., McDaniel L., Diamond M., Padovan O., Raman P., Li Y., Wei J.S., et al. CASC15-S is a tumor suppressor lncRNA at the 6p22 neuroblastoma susceptibility locus. Cancer Res. 2015;75:3155-3166.
Not in our library10.1158/0008-5472.can-14-3613
381.
Pandey G.K., Mitra S., Subhash S., Hertwig F., Kanduri M., Mishra K., Fransson S., Ganeshram A., Mondal T., Bandaru S., et al. The Risk-Associated Long Noncoding RNA NBAT-1 Controls Neuroblastoma Progression by Regulating Cell Proliferation and Neuronal Differentiation. Cancer Cell. 2014;26:722-737.
Not in our library10.1016/j.ccell.2014.09.014
382.
The long non‐coding RNA Paupar regulates the expression of both local and distal genes · 2014
No notice
383.
Pavlaki I., Alammari F., Sun B., Clark N., Sirey T., Lee S., Woodcock D.J., Ponting C.P., Szele F.G., Vance K.W. The long non-coding RNA Paupar promotes KAP 1-dependent chromatin changes and regulates olfactory bulb neurogenesis. EMBO J. 2018;37:e98219.
Not in our library10.15252/embj.201798219
384.
Li D., Wang X., Mei H., Fang E., Ye L., Song H., Yang F., Li H., Huang K., Zheng L., et al. Long Noncoding RNA pancEts-1 Promotes Neuroblastoma Progression through hnRNPK-Mediated β-Catenin Stabilization. Cancer Res. 2018;78:1169-1183.
Not in our library10.1158/0008-5472.can-17-2295
385.
Zhang J., Li W.Y., Yang Y., Yan L.Z., Zhang S.Y., He J., Wang J.X. LncRNA XIST facilitates cell growth, migration and invasion via modulating H3 histone methylation of DKK1 in neuroblastoma. Cell Cycle. 2019;18:1882-1892.
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Atmadibrata B., Liu P.Y., Sokolowski N., Zhang L., Wong M., Tee A.E., Marshall G.M., Liu T. The Novel Long Noncoding RNA linc00467 Promotes Cell Survival but Is Down-Regulated by N-Myc. PLoS ONE. 2014;9:e88112.
Not in our library10.1371/journal.pone.0088112
388.
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Not in our library10.1016/j.ymthe.2017.12.017

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