Multidrug-Resistant Mycobacterium tuberculosis : Molecular Perspectives

Abstract

Multidrug-resistant strains of Mycobacterium tuberculosis seriously threaten tuberculosis (TB) control and prevention efforts. Molecular studies of the mechanism of action of antitubercular drugs have elucidated the genetic basis of drug resistance in M. tuberculosis. Drug resistance in M. tuberculosis is attributed primarily to the accumulation of mutations in the drug target genes; these mutations lead either to an altered target (e.g., RNA polymerase and catalase-peroxidase in rifampicin and isoniazid resistance, respectively) or to a change in titration of the drug (e.g., InhA in isoniazid resistance). Development of specific mechanism-based inhibitors and techniques to rapidly detect multidrug resistance will require further studies addressing the drug and drug-target interaction.

References 100

1. 1.

   Altamirano M., Marostenmaki J., Wong A., FitzGerald M., Black W. A., Smith J. A. Mutations in the catalase-peroxidase gene from isoniazid-resistant Mycobacterium tuberculosis isolates. J Infect Dis. 1994;169(5):1162-1165.

   Not in our library10.1093/infdis/169.5.1162

2. 2.

   Banerjee A., Dubnau E., Quemard A., Balasubramanian V., Um K. S., Wilson T., Collins D., de Lisle G., Jacobs W. R. inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis. Science. 1994;263(5144):227-230.

   Not in our library10.1126/science.8284673

3. 3.

   Barnes P. F., Bloch A. B., Davidson P. T., Snider D. E. Tuberculosis in patients with human immunodeficiency virus infection. N Engl J Med. 1991;324(23):1644-1650.

   Not in our library10.1056/nejm199106063242307

4. 4.

   Belanger A. E., Besra G. S., Ford M. E., Mikusová K., Belisle J. T., Brennan P. J., Inamine J. M. The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Proc Natl Acad Sci U S A. 1996;93(21):11919-11924.

   Not in our library10.1073/pnas.93.21.11919

5. 5.

   Bell R. T. Tuberculosis of the 1990s: the quiet public health threat. Pa Med. 1992;95(3):24-25.

   Not in our library

6. 6.

   Benveniste R., Davies J. Mechanisms of antibiotic resistance in bacteria. Annu Rev Biochem. 1973;42:471-506.

   Not in our library10.1146/annurev.bi.42.070173.002351

7. 7.

   Bergler H., Wallner P., Ebeling A., Leitinger B., Fuchsbichler S., Aschauer H., Kollenz G., Högenauer G., Turnowsky F. Protein EnvM is the NADH-dependent enoyl-ACP reductase (FabI) of Escherichia coli. J Biol Chem. 1994;269(8):5493-5496.

   Not in our library

8. 8.

   Bloom B. R., Murray C. J. Tuberculosis: commentary on a reemergent killer. Science. 1992;257(5073):1055-1064.

   Not in our library10.1126/science.257.5073.1055

9. 9.

   Chae H. Z., Robison K., Poole L. B., Church G., Storz G., Rhee S. G. Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes. Proc Natl Acad Sci U S A. 1994;91(15):7017-7021.

   Not in our library10.1073/pnas.91.15.7017

10. 10.

    Cockerill F. R., Uhl J. R., Temesgen Z., Zhang Y., Stockman L., Roberts G. D., Williams D. L., Kline B. C. Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase-peroxidase (katG) gene associated with isoniazid resistance. J Infect Dis. 1995;171(1):240-245.

    Not in our library10.1093/infdis/171.1.240

11. 11.

    Cohn D. L., Bustreo F., Raviglione M. C. Drug-resistant tuberculosis: review of the worldwide situation and the WHO/IUATLD Global Surveillance Project. International Union Against Tuberculosis and Lung Disease. Clin Infect Dis. 1997;24(Suppl 1):S121-S130.

    Not in our library10.1093/clinids/24.supplement_1.s121

12. 12.

    Cole S. T. Mycobacterium tuberculosis: drug-resistance mechanisms. Trends Microbiol. 1994;2(10):411-415.

    Not in our library10.1016/0966-842x(94)90621-1

13. 13.

    Cooksey R. C., Morlock G. P., Glickman S., Crawford J. T. Evaluation of a line probe assay kit for characterization of rpoB mutations in rifampin-resistant Mycobacterium tuberculosis isolates from New York City. J Clin Microbiol. 1997;35(5):1281-1283.

    Not in our library10.1128/jcm.35.5.1281-1283.1997

14. 14.

    Davies J., Wright G. D. Bacterial resistance to aminoglycoside antibiotics. Trends Microbiol. 1997;5(6):234-240.

    Not in our library10.1016/s0966-842x(97)01033-0

15. 15.

    De Beenhouwer H., Lhiang Z., Jannes G., Mijs W., Machtelinckx L., Rossau R., Traore H., Portaels F. Rapid detection of rifampicin resistance in sputum and biopsy specimens from tuberculosis patients by PCR and line probe assay. Tuber Lung Dis. 1995;76(5):425-430.

    Not in our library10.1016/0962-8479(95)90009-8

16. 16.

    Demple B., Halbrook J. Inducible repair of oxidative DNA damage in Escherichia coli. Nature. 1983;304(5925):466-468.

    Not in our library10.1038/304466a0

17. 17.

    Deretic V., Philipp W., Dhandayuthapani S., Mudd M. H., Curcic R., Garbe T., Heym B., Via L. E., Cole S. T. Mycobacterium tuberculosis is a natural mutant with an inactivated oxidative-stress regulatory gene: implications for sensitivity to isoniazid. Mol Microbiol. 1995;17(5):889-900.

    Not in our library10.1111/j.1365-2958.1995.mmi_17050889.x

18. 18.

    Dessen A., Quémard A., Blanchard J. S., Jacobs W. R., Sacchettini J. C. Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis. Science. 1995;267(5204):1638-1641.

    Not in our library10.1126/science.7886450

19. 19.

    Dooley S. W., Jarvis W. R., Martone W. J., Snider D. E. Multidrug-resistant tuberculosis. Ann Intern Med. 1992;117(3):257-259.

    Not in our library10.7326/0003-4819-117-3-257

20. 20.

    Douglass J., Steyn L. M. A ribosomal gene mutation in streptomycin-resistant Mycobacterium tuberculosis isolates. J Infect Dis. 1993;167(6):1505-1506.

    Not in our library10.1093/infdis/167.6.1505

21. 21.

    Edlin B. R., Tokars J. I., Grieco M. H., Crawford J. T., Williams J., Sordillo E. M., Ong K. R., Kilburn J. O., Dooley S. W., Castro K. G. An outbreak of multidrug-resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome. N Engl J Med. 1992;326(23):1514-1521.

    Not in our library10.1056/nejm199206043262302

22. 22.

    Felmlee T. A., Liu Q., Whelen A. C., Williams D., Sommer S. S., Persing D. H. Genotypic detection of Mycobacterium tuberculosis rifampin resistance: comparison of single-strand conformation polymorphism and dideoxy fingerprinting. J Clin Microbiol. 1995;33(6):1617-1623.

    Not in our library10.1128/jcm.33.6.1617-1623.1995

23. 23.

    Finken M., Kirschner P., Meier A., Wrede A., Böttger E. C. Molecular basis of streptomycin resistance in Mycobacterium tuberculosis: alterations of the ribosomal protein S12 gene and point mutations within a functional 16S ribosomal RNA pseudoknot. Mol Microbiol. 1993;9(6):1239-1246.

    Not in our library10.1111/j.1365-2958.1993.tb01253.x

24. 24.

    Frieden T. R., Sterling T., Pablos-Mendez A., Kilburn J. O., Cauthen G. M., Dooley S. W. The emergence of drug-resistant tuberculosis in New York City. N Engl J Med. 1993;328(8):521-526.

    Not in our library10.1056/nejm199302253280801

25. 25.

    Gay J. D., DeYoung D. R., Roberts G. D. In vitro activities of norfloxacin and ciprofloxacin against Mycobacterium tuberculosis, M. avium complex, M. chelonei, M. fortuitum, and M. kansasii. Antimicrob Agents Chemother. 1984;26(1):94-96.

    Not in our library10.1128/aac.26.1.94

26. 26.

    Gellert M., Mizuuchi K., O'Dea M. H., Nash H. A. DNA gyrase: an enzyme that introduces superhelical turns into DNA. Proc Natl Acad Sci U S A. 1976;73(11):3872-3876.

    Not in our library10.1073/pnas.73.11.3872

27. 27.

    Gellert M., O'Dea M. H., Itoh T., Tomizawa J. Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase. Proc Natl Acad Sci U S A. 1976;73(12):4474-4478.

    Not in our library10.1073/pnas.73.12.4474

28. 28.

    Grange J. M. Drug resistance and tuberculosis elimination. Bull Int Union Tuberc Lung Dis. 1990;65(2-3):57-59.

    Not in our library

29. 29.

    Heifets L., Lindholm-Levy P. Pyrazinamide sterilizing activity in vitro against semidormant Mycobacterium tuberculosis bacterial populations. Am Rev Respir Dis. 1992;145(5):1223-1225.

    Not in our library10.1164/ajrccm/145.5.1223

30. 30.

    Hewlett D., Horn D. L., Alfalla C. Drug-resistant tuberculosis: inconsistent results of pyrazinamide susceptibility testing. JAMA. 1995;273(12):916-917.

    Not in our library

31. 31.

    Heym B., Alzari P. M., Honoré N., Cole S. T. Missense mutations in the catalase-peroxidase gene, katG, are associated with isoniazid resistance in Mycobacterium tuberculosis. Mol Microbiol. 1995;15(2):235-245.

    Not in our library10.1111/j.1365-2958.1995.tb02238.x

32. 32.

    Heym B., Honoré N., Truffot-Pernot C., Banerjee A., Schurra C., Jacobs W. R., van Embden J. D., Grosset J. H., Cole S. T. Implications of multidrug resistance for the future of short-course chemotherapy of tuberculosis: a molecular study. Lancet. 1994;344(8918):293-298.

    Not in our library10.1016/s0140-6736(94)91338-2

33. 33.

    Heym B., Stavropoulos E., Honoré N., Domenech P., Saint-Joanis B., Wilson T. M., Collins D. M., Colston M. J., Cole S. T. Effects of overexpression of the alkyl hydroperoxide reductase AhpC on the virulence and isoniazid resistance of Mycobacterium tuberculosis. Infect Immun. 1997;65(4):1395-1401.

    Not in our library10.1128/iai.65.4.1395-1401.1997

34. 34.

    Higgins N. P., Peebles C. L., Sugino A., Cozzarelli N. R. Purification of subunits of Escherichia coli DNA gyrase and reconstitution of enzymatic activity. Proc Natl Acad Sci U S A. 1978;75(4):1773-1777.

    Not in our library10.1073/pnas.75.4.1773

35. 35.

    Honoré N., Cole S. T. Streptomycin resistance in mycobacteria. Antimicrob Agents Chemother. 1994;38(2):238-242.

    Not in our library10.1128/aac.38.2.238

36. 36.

    Iseman M. D., Madsen L. A. Drug-resistant tuberculosis. Clin Chest Med. 1989;10(3):341-353.

    Not in our library

37. 37.

    Iseman M. D., Sbarbaro J. A. The increasing prevalence of resistance to antituberculosis chemotherapeutic agents: implications for global tuberculosis control. Curr Clin Top Infect Dis. 1992;12:188-207.

    Not in our library

38. 38.

    Jaber M., Rattan A., Kumar R. Presence of katG gene in resistant Mycobacterium tuberculosis. J Clin Pathol. 1996;49(11):945-947.

    Not in our library10.1136/jcp.49.11.945

39. 39.

    Jin D. J., Gross C. A. Mapping and sequencing of mutations in the Escherichia coli rpoB gene that lead to rifampicin resistance. J Mol Biol. 1988;202(1):45-58.

    Not in our library10.1016/0022-2836(88)90517-7

40. 40.

    Johnsson K., Froland W. A., Schultz P. G. Overexpression, purification, and characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis. J Biol Chem. 1997;272(5):2834-2840.

    Not in our library10.1074/jbc.272.5.2834

Cited by papers we hold 4

• Prevalence of drug resistance-conferring mutations associated with isoniazid- and rifampicin-resistant Mycobacterium tuberculosis in Ethiopia: a systematic review and meta-analysis · 2021
  Not checked
• Genetic Mutations Associated with Isoniazid Resistance in Mycobacterium tuberculosis: A Systematic Review · 2015
  No notice
• Combining blue native polyacrylamide gel electrophoresis with liquid chromatography tandem mass spectrometry as an effective strategy for analyzing potential membrane protein complexes of <it>Mycobacterium bovis </it>bacillus Calmette-Guérin · 2011
  Not checked
• Tuberculosis: A Global Health Problem · 2010
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.