Multidrug-Resistant Mycobacterium tuberculosis : Molecular Perspectives

Abstract

Multidrug-resistant strains of Mycobacterium tuberculosis seriously threaten tuberculosis (TB) control and prevention efforts. Molecular studies of the mechanism of action of antitubercular drugs have elucidated the genetic basis of drug resistance in M. tuberculosis. Drug resistance in M. tuberculosis is attributed primarily to the accumulation of mutations in the drug target genes; these mutations lead either to an altered target (e.g., RNA polymerase and catalase-peroxidase in rifampicin and isoniazid resistance, respectively) or to a change in titration of the drug (e.g., InhA in isoniazid resistance). Development of specific mechanism-based inhibitors and techniques to rapidly detect multidrug resistance will require further studies addressing the drug and drug-target interaction.

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88. 88.

    Telenti A., Imboden P., Marchesi F., Schmidheini T., Bodmer T. Direct, automated detection of rifampin-resistant Mycobacterium tuberculosis by polymerase chain reaction and single-strand conformation polymorphism analysis. Antimicrob Agents Chemother. 1993;37(10):2054-2058.

    Not in our library10.1128/aac.37.10.2054

89. 89.

    Telenti A., Persing D. H. Novel strategies for the detection of drug resistance in Mycobacterium tuberculosis. Res Microbiol. 1996;147(1-2):73-79.

    Not in our library10.1016/0923-2508(96)80207-5

90. 90.

    Telenti A., Philipp W. J., Sreevatsan S., Bernasconi C., Stockbauer K. E., Wieles B., Musser J. M., Jacobs W. R. The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol. Nat Med. 1997;3(5):567-570.

    Not in our library10.1038/nm0597-567

91. 91.

    Vareldzis B. P., Grosset J., de Kantor I., Crofton J., Laszlo A., Felten M., Raviglione M. C., Kochi A. Drug-resistant tuberculosis: laboratory issues. World Health Organization recommendations. Tuber Lung Dis. 1994;75(1):1-7.

    Not in our library10.1016/0962-8479(94)90096-5

92. 92.

    Whelen A. C., Felmlee T. A., Hunt J. M., Williams D. L., Roberts G. D., Stockman L., Persing D. H. Direct genotypic detection of Mycobacterium tuberculosis rifampin resistance in clinical specimens by using single-tube heminested PCR. J Clin Microbiol. 1995;33(3):556-561.

    Not in our library10.1128/jcm.33.3.556-561.1995

93. 93.

    Williams D. L., Waguespack C., Eisenach K., Crawford J. T., Portaels F., Salfinger M., Nolan C. M., Abe C., Sticht-Groh V., Gillis T. P. Characterization of rifampin-resistance in pathogenic mycobacteria. Antimicrob Agents Chemother. 1994;38(10):2380-2386.

    Not in our library10.1128/aac.38.10.2380

94. 94.

    Willmott C. J., Critchlow S. E., Eperon I. C., Maxwell A. The complex of DNA gyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase. J Mol Biol. 1994;242(4):351-363.

    Not in our library10.1006/jmbi.1994.1586

95. 95.

    Wilson T. M., Collins D. M. ahpC, a gene involved in isoniazid resistance of the Mycobacterium tuberculosis complex. Mol Microbiol. 1996;19(5):1025-1034.

    Not in our library10.1046/j.1365-2958.1996.449980.x

96. 96.

    Woese C. R., Gutell R. R. Evidence for several higher order structural elements in ribosomal RNA. Proc Natl Acad Sci U S A. 1989;86(9):3119-3122.

    Not in our library10.1073/pnas.86.9.3119

97. 97.

    Wolucka B. A., McNeil M. R., de Hoffmann E., Chojnacki T., Brennan P. J. Recognition of the lipid intermediate for arabinogalactan/arabinomannan biosynthesis and its relation to the mode of action of ethambutol on mycobacteria. J Biol Chem. 1994;269(37):23328-23335.

    Not in our library

98. 98.

    Woodley C. L., Kilburn J. O., David H. L., Silcox V. A. Susceptibility of mycobacteria to rifampin. Antimicrob Agents Chemother. 1972;2(4):245-249.

    Not in our library10.1128/aac.2.4.245

99. 99.

    Zhang Y., Garbe T., Young D. Transformation with katG restores isoniazid-sensitivity in Mycobacterium tuberculosis isolates resistant to a range of drug concentrations. Mol Microbiol. 1993;8(3):521-524.

    Not in our library10.1111/j.1365-2958.1993.tb01596.x

100. 100.

     Zhang Y., Heym B., Allen B., Young D., Cole S. The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis. Nature. 1992;358(6387):591-593.

     Not in our library10.1038/358591a0

Cited by papers we hold 4

• Prevalence of drug resistance-conferring mutations associated with isoniazid- and rifampicin-resistant Mycobacterium tuberculosis in Ethiopia: a systematic review and meta-analysis · 2021
  Not checked
• Genetic Mutations Associated with Isoniazid Resistance in Mycobacterium tuberculosis: A Systematic Review · 2015
  No notice
• Combining blue native polyacrylamide gel electrophoresis with liquid chromatography tandem mass spectrometry as an effective strategy for analyzing potential membrane protein complexes of <it>Mycobacterium bovis </it>bacillus Calmette-Guérin · 2011
  Not checked
• Tuberculosis: A Global Health Problem · 2010
  No notice

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