Drosophila as a Genetic Model for Hematopoiesis

Abstract

In this FlyBook chapter, we present a survey of the current literature on the development of the hematopoietic system in Drosophila. The Drosophila blood system consists entirely of cells that function in innate immunity, tissue integrity, wound healing, and various forms of stress response, and are therefore functionally similar to myeloid cells in mammals. The primary cell types are specialized for phagocytic, melanization, and encapsulation functions. As in mammalian systems, multiple sites of hematopoiesis are evident in Drosophila and the mechanisms involved in this process employ many of the same molecular strategies that exemplify blood development in humans. Drosophila blood progenitors respond to internal and external stress by coopting developmental pathways that involve both local and systemic signals. An important goal of these Drosophila studies is to develop the tools and mechanisms critical to further our understanding of human hematopoiesis during homeostasis and dysfunction.

Shown for reading. Its publisher allows quoting it, not republishing it.

References 379

1. 1.

   Abel T. Michelson A. M. Maniatis T., 1993 A Drosophila GATA family member that binds to Adh regulatory sequences is expressed in the developing fat body. Development 119: 623–633.

   Not in our library10.1242/dev.119.3.623

2. 2.

   Agaisse H. Petersen U. M. Boutros M. Mathey-Prevot B. Perrimon N., 2003 Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev. Cell 5: 441–450.

   Not in our library10.1016/s1534-5807(03)00244-2

3. 3.

   Alfonso T. B. Jones B. W., 2002 gcm2 promotes glial cell differentiation and is required with glial cells missing for macrophage development in Drosophila. Dev. Biol. 248: 369–383.

   Not in our library10.1006/dbio.2002.0740

4. 4.

   Amcheslavsky A. Jiang J. Ip Y. T., 2009 Tissue damage-induced intestinal stem cell division in Drosophila. Cell Stem Cell 4: 49–61.

   Not in our library10.1016/j.stem.2008.10.016

5. 5.
   Transdifferentiation and Proliferation in Two Distinct Hemocyte Lineages in Drosophila melanogaster Larvae after Wasp Infection · 2016

   No notice
6. 6.

   Arendt D. Tessmar-Raible K. Snyman H. Dorresteijn A. W. Wittbrodt J., 2004 Ciliary photoreceptors with a vertebrate-type opsin in an invertebrate brain. Science 306: 869–871.

   Not in our library10.1126/science.1099955

7. 7.

   Asha H. Nagy I. Kovacs G. Stetson D. Ando I., 2003 Analysis of Ras-induced overproliferation in Drosophila hemocytes. Genetics 163: 203–215.

   Not in our library10.1093/genetics/163.1.203

8. 8.

   Avet-Rochex A. Bergeret E. Attree I. Meister M. Fauvarque M. O., 2005 Suppression of Drosophila cellular immunity by directed expression of the ExoS toxin GAP domain of Pseudomonas aeruginosa. Cell. Microbiol. 7: 799–810.

   Not in our library10.1111/j.1462-5822.2005.00512.x

9. 9.

   Avet-Rochex A. Perrin J. Bergeret E. Fauvarque M. O., 2007 Rac2 is a major actor of Drosophila resistance to Pseudomonas aeruginosa acting in phagocytic cells. Genes Cells 12: 1193–1204.

   Not in our library10.1111/j.1365-2443.2007.01121.x

10. 10.

    Avet-Rochex A. Boyer K. Polesello C. Gobert V. Osman D., 2010 An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis. BMC Dev. Biol. 10: 65

    Not in our library10.1186/1471-213x-10-65

11. 11.
    A Signaling Protease Required for Melanization in Drosophila Affects Resistance and Tolerance of Infections · 2008

    No notice
12. 12.

    Ayyaz A. Li H. Jasper H., 2015 Haemocytes control stem cell activity in the Drosophila intestine. Nat. Cell Biol. 17: 736–748.

    Not in our library10.1038/ncb3174

13. 13.

    Azpiazu N. Lawrence P. A. Vincent J. P. Frasch M., 1996 Segmentation and specification of the Drosophila mesoderm. Genes Dev. 10: 3183–3194.

    Not in our library10.1101/gad.10.24.3183

14. 14.

    Babcock D. T. Brock A. R. Fish G. S. Wang Y. Perrin L., 2008 Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae. Proc. Natl. Acad. Sci. USA 105: 10017–10022.

    Not in our library10.1073/pnas.0709951105

15. 15.

    Bajgar A. Dolezal T., 2018 Extracellular adenosine modulates host-pathogen interactions through regulation of systemic metabolism during immune response in Drosophila. PLoS Pathog. 14: e1007022

    Not in our library10.1371/journal.ppat.1007022

16. 16.
    Extracellular Adenosine Mediates a Systemic Metabolic Switch during Immune Response · 2015

    No notice
17. 17.

    Baldeosingh R. Gao H. Wu X. Fossett N., 2018 Hedgehog signaling from the posterior signaling center maintains U-shaped expression and a prohemocyte population in Drosophila. Dev. Biol. 441: 132–145.

    Not in our library10.1016/j.ydbio.2018.06.020

18. 18.
    The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response · 2000

    Not checked
19. 19.

    Bataille L. Auge B. Ferjoux G. Haenlin M. Waltzer L., 2005 Resolving embryonic blood cell fate choice in Drosophila: interplay of GCM and RUNX factors. Development 132: 4635–4644.

    Not in our library10.1242/dev.02034

20. 20.

    Bate M. Rushton E., 1993 Myogenesis and muscle patterning in Drosophila. C. R. Acad. Sci. III 316: 1047–1061.

    Not in our library

21. 21.

    Beiman M. Shilo B. Z. Volk T., 1996 Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages. Genes Dev. 10: 2993–3002.

    Not in our library10.1101/gad.10.23.2993

22. 22.

    Belenkaya T. Y. Han C. Yan D. Opoka R. J. Khodoun M., 2004 Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans. Cell 119: 231–244.

    Not in our library10.1016/j.cell.2004.09.031

23. 23.

    Benmimoun B. Polesello C. Waltzer L. Haenlin M., 2012 Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila. Development 139: 1713–1717.

    Not in our library10.1242/dev.080259

24. 24.

    Benmimoun B. Polesello C. Haenlin M. Waltzer L., 2015 The EBF transcription factor Collier directly promotes Drosophila blood cell progenitor maintenance independently of the niche. Proc. Natl. Acad. Sci. USA 112: 9052–9057.

    Not in our library10.1073/pnas.1423967112

25. 25.

    Bergmann A. Agapite J. McCall K. Steller H., 1998 The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95: 331–341.

    Not in our library10.1016/s0092-8674(00)81765-1

26. 26.

    Bernardoni R. Vivancos V. Giangrande A., 1997 Glide/gcm is expressed and required in the scavenger cell lineage. Dev. Biol. 191: 118–130.

    Not in our library10.1006/dbio.1997.8702

27. 27.

    Bidla G. Lindgren M. Theopold U. Dushay M. S., 2005 Hemolymph coagulation and phenoloxidase in Drosophila larvae. Dev. Comp. Immunol. 29: 669–679.

    Not in our library10.1016/j.dci.2004.11.007

28. 28.

    Bidla G. Dushay M. S. Theopold U., 2007 Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger. J. Cell Sci. 120: 1209–1215.

    Not in our library10.1242/jcs.03420

29. 29.
    Prophenoloxidase Activation Is Required for Survival to Microbial Infections in Drosophila · 2014

    No notice
30. 30.

    Bitra K. Suderman R. J. Strand M. R., 2012 Polydnavirus Ank proteins bind NF-kappaB homodimers and inhibit processing of Relish. PLoS Pathog. 8: e1002722

    Not in our library10.1371/journal.ppat.1002722

31. 31.

    Bodmer R., 1993 The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development 118: 719–729.

    Not in our library10.1242/dev.118.3.719

32. 32.

    Bodmer R. Jan L. Y. Jan Y. N., 1990 A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila. Development 110: 661–669.

    Not in our library10.1242/dev.110.3.661

33. 33.

    Borkowski O. M. Brown N. H. Bate M., 1995 Anterior-posterior subdivision and the diversification of the mesoderm in Drosophila. Development 121: 4183–4193.

    Not in our library10.1242/dev.121.12.4183

34. 34.
    Secreted Bacterial Effectors and Host-Produced Eiger/TNF Drive Death in a Salmonella-Infected Fruit Fly · 2004

    No notice
35. 35.

    Braun A. Lemaitre B. Lanot R. Zachary D. Meister M., 1997 Drosophila immunity: analysis of larval hemocytes by P-element-mediated enhancer trap. Genetics 147: 623–634.

    Not in our library10.1093/genetics/147.2.623

36. 36.

    Braun A. Hoffmann J. A. Meister M., 1998 Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes. Proc. Natl. Acad. Sci. USA 95: 14337–14342.

    Not in our library10.1073/pnas.95.24.14337

37. 37.

    Brennan C. A. Anderson K. V., 2004 Drosophila: the genetics of innate immune recognition and response. Annu. Rev. Immunol. 22: 457–483.

    Not in our library10.1146/annurev.immunol.22.012703.104626

38. 38.

    Brennan C. A. Delaney J. R. Schneider D. S. Anderson K. V., 2007 Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body. Curr. Biol. 17: 67–72.

    Not in our library10.1016/j.cub.2006.11.026

39. 39.

    Brennan J. J. Messerschmidt J. L. Williams L. M. Matthews B. J. Reynoso M., 2017 Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development. Proc. Natl. Acad. Sci. USA 114: E10122–E10131.

    Not in our library10.1073/pnas.1711530114

40. 40.

    Bretscher A. J. Honti V. Binggeli O. Burri O. Poidevin M., 2015 The Nimrod transmembrane receptor Eater is required for hemocyte attachment to the sessile compartment in Drosophila melanogaster. Biol. Open 4: 355–363.

    Not in our library10.1242/bio.201410595

Cited by papers we hold 5

• Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues · 2022
  No notice
• Phospho-Site Mutations in Transcription Factor Suppressor of Hairless Impact Notch Signaling Activity During Hematopoiesis in Drosophila · 2021
  Not checked
• From Species to Regional and Local Specialization of Intestinal Macrophages · 2021
  Not checked
• Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila · 2020
  No notice
• A single-cell survey of Drosophila blood · 2020
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.