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Drosophila as a Genetic Model for Hematopoiesis

Utpal Banerjee, Juliet R Girard, Lauren M Goins and 1 more

Genetics · 2019 · Review

doi:10.1534/genetics.118.300223

Abstract

In this FlyBook chapter, we present a survey of the current literature on the development of the hematopoietic system in Drosophila. The Drosophila blood system consists entirely of cells that function in innate immunity, tissue integrity, wound healing, and various forms of stress response, and are therefore functionally similar to myeloid cells in mammals. The primary cell types are specialized for phagocytic, melanization, and encapsulation functions. As in mammalian systems, multiple sites of hematopoiesis are evident in Drosophila and the mechanisms involved in this process employ many of the same molecular strategies that exemplify blood development in humans. Drosophila blood progenitors respond to internal and external stress by coopting developmental pathways that involve both local and systemic signals. An important goal of these Drosophila studies is to develop the tools and mechanisms critical to further our understanding of human hematopoiesis during homeostasis and dysfunction.

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Dynamic labelling of neural connections in multiple colours by trans-synaptic fluorescence complementation · 2015
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199.
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Cited by papers we hold 5

Drosophila Innate Immunity Involves Multiple Signaling Pathways and Coordinated Communication Between Different Tissues · 2022
No notice
Phospho-Site Mutations in Transcription Factor Suppressor of Hairless Impact Notch Signaling Activity During Hematopoiesis in Drosophila · 2021
Not checked
From Species to Regional and Local Specialization of Intestinal Macrophages · 2021
Not checked
Single-cell transcriptome maps of myeloid blood cell lineages in Drosophila · 2020
No notice
A single-cell survey of Drosophila blood · 2020
No notice

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