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Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization
Gennaro D’Amato, Stephen T. Holgate, Ruby Pawankar and 37 more
World Allergy Organization Journal · 2015 · CC BY-NC-ND
Abstract
The prevalence of allergic airway diseases such as asthma and rhinitis has increased dramatically to epidemic proportions worldwide. Besides air pollution from industry derived emissions and motor vehicles, the rising trend can only be explained by gross changes in the environments where we live. The world economy has been transformed over the last 25 years with developing countries being at the core of these changes. Around the planet, in both developed and developing countries, environments are undergoing profound changes. Many of these changes are considered to have negative effects on respiratory health and to enhance the frequency and severity of respiratory diseases such as asthma in the general population. Increased concentrations of greenhouse gases, and especially carbon dioxide (CO2), in the atmosphere have already warmed the planet substantially, causing more severe and prolonged heat waves, variability in temperature, increased air pollution, forest fires, droughts, and floods - all of which can put the respiratory health of the public at risk. These changes in climate and air quality have a measurable impact not only on the morbidity but also the mortality of patients with asthma and other respiratory diseases. The massive increase in emissions of air pollutants due to economic and industrial growth in the last century has made air quality an environmental problem of the first order in a large number of regions of the world. A body of evidence suggests that major changes to our world are occurring and involve the atmosphere and its associated climate. These changes, including global warming induced by human activity, have an impact on the biosphere, biodiversity, and the human environment. Mitigating this huge health impact and reversing the effects of these changes are major challenges. This statement of the World Allergy Organization (WAO) raises the importance of this health hazard and highlights the facts on climate-related health impacts, including: deaths and acute morbidity due to heat waves and extreme meteorological events; increased frequency of acute cardio-respiratory events due to higher concentrations of ground level ozone; changes in the frequency of respiratory diseases due to trans-boundary particle pollution; altered spatial and temporal distribution of allergens (pollens, molds, and mites); and some infectious disease vectors. According to this report, these impacts will not only affect those with current asthma but also increase the incidence and prevalence of allergic respiratory conditions and of asthma. The effects of climate change on respiratory allergy are still not well defined, and more studies addressing this topic are needed. Global warming is expected to affect the start, duration, and intensity of the pollen season on the one hand, and the rate of asthma exacerbations due to air pollution, respiratory infections, and/or cold air inhalation, and other conditions on the other hand.
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References 419
- 1.
Lombardi C, Canonica GW, Passalacqua G. IGRAM, Italian group on respiratory allergy in migrants. The possible influence of the environment on respiratory allergy: a survey on immigrants to Italy. Ann Allergy Asthma Immunol. 2011;106:407-11.
Not in our library10.1016/j.anai.2011.01.023
- 2.
Cecchi L, Morabito M, Domeneghetti MP, Crisci A, Onorari M, Orlandini S. Long-distance transport of ragweed pollen as a potential cause of allergy in central Italy. Ann Allergy Asthma Immunol. 2006;96:86-91.
Not in our library10.1016/s1081-1206(10)61045-9
- 3.
- 4.
Mayer D, Branscheid D. Exposure of human lung fibroblasts to ozone: cell mortality and hyaluronan metabolism. J Toxicol Environ Health. 1992;35:235-46.
Not in our library10.1080/15287399209531614
- 5.
Samet JM, Noah TL, Devlin RB, Yankaskas JR, McKinnon K, Dailey LA, et al. Effect of ozone on platelet activating factor production in phorbol-differentiated HL60 cells, a human bronchial epithelial cell line (BEAS S6) and primary human bronchial epithelial cells. Am J Respir Cell Mol Biol. 1992;7:514-22.
Not in our library10.1165/ajrcmb/7.5.514
- 6.
Arsalane K, Gosset P, Vanhee D, Voisin C, Hamid Q, Tonnel AB, et al. Ozone stimulates synthesis of inflammatory cytokines by alveolar macrophages in vitro. Am J Respir Cell Mol Biol. 1995;13:60-8.
Not in our library10.1165/ajrcmb.13.1.7598938
- 7.
Bachoual R, Boczkowski J, Goven D, Amara N, Tabet L, On D, et al. Biological effects of particles from the Paris subway system. Chem Res Toxicol. 2007;20:1426-33.
Not in our library10.1021/tx700093j
- 8.
Diaz-Sanchez D. The role of diesel exhaust particles and their associated polyaromatic hydrocarbons in the induction of allergic airway disease. Allergy. 1997;52(suppl 38):52-6.
Not in our library10.1111/j.1398-9995.1997.tb04871.x
- 9.
Devalia JL, Bayram H, Rusznak C, Calderón M, Sapsford RJ, Abdelaziz MA, et al. Mechanisms of pollution-induced airways disease - in vitro studies in the upper and lower airways. Allergy. 1997;52(suppl 38):45-51.
Not in our library10.1111/j.1398-9995.1997.tb04870.x
- 10.
Bayram H, Devalia JL, Sapsford RJ, Ohtoshi T, Miyabara Y, Sagai M, et al. The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am J Respir Cell Mol Biol. 1998;18:441-8.
Not in our library10.1165/ajrcmb.18.3.2882
- 11.
Bayram H, Devalia JL, Khair OA, Abdelaziz MM, Sapsford RJ, Sagai M, et al. Comparison of ciliary activity and inflammatory mediator release from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients and the effect of diesel exhaust particles in vitro. J Allergy Clin Immunol. 1998;102:771-82.
Not in our library10.1016/s0091-6749(98)70017-x
- 12.
Bayram H, Devalia JL, Khair OA, Abdelaziz MM, Sapsford RJ, Czarlewski W, et al. Effect of loratadine on nitrogen dioxide (NO2)-induced changes in electrical resistance and release of inflammatory mediators from cultured human bronchial epithelial cells. J Allergy Clin Immunol. 1999;104:93-9.
Not in our library10.1016/s0091-6749(99)70119-3
- 13.
Bayram H, Rusznak C, Khair OA, Sapsford RJ, Abdelaziz MM. Effect of ozone and nitrogen dioxide on the permeability of bronchial epithelial cell cultures of non-asthmatic and asthmatic subjects. Clin Exp Allergy. 2002;32:1285-92.
Not in our library10.1046/j.1365-2745.2002.01435.x
- 14.
Rusznak C, Devalia JL, Sapsford RJ, Davies RJ. Ozone-induced mediator release from human bronchial epithelial cells in vitro and the influence of nedocromil sodium. Eur Respir J. 1996;9:2296-305.
Not in our library10.1183/09031936.96.09112298
- 15.
Bayram H, Sapsford RJ, Abdelaziz MM, Khair OA. Effect of ozone and nitrogen dioxide on the release of pro-inflammatory mediators from bronchial epithelial cells of non-atopic non-asthmatic subjects and atopic asthmatic patients, in vitro. J Allergy Clin Immunol. 2001;107:287-94.
Not in our library10.1067/mai.2001.111141
- 16.
Takizawa R, Pawankar R, Yamagishi S, Takenaka H, Yagi T. Increased expression of HLA-DR and CD86 in nasal epithelial cells in allergic rhinitis: antigen presentation to T cells and up-regulation by diesel exhaust particles. Clin Exp Allergy. 2007;37:420-33.
Not in our library10.1111/j.1365-2222.2007.02672.x
- 17.
Ercan H, Birben E, Dizdar EA, Keskin O, Karaaslan C, Soyer OU, et al. Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma. J Allergy Clin Immunol. 2006;118:1097-104.
Not in our library10.1016/j.jaci.2006.08.012
- 18.
Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al. Global initiative for chronic obstructive lung disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2007;176:532-55.
Not in our library10.1164/rccm.200703-456so
- 19.
Brunekreef B, Holgate ST. Air pollution and health. Lancet. 2002;360(9341):1233-42.
Not in our library10.1016/s0140-6736(02)11274-8
- 20.
Manzo ND, LaGier AJ, Slade R, Ledbetter AD, Richards JH, Dye JA. Nitric oxide and superoxide mediate diesel particle effects in cytokine-treated mice and murine lung epithelial cells – implications for susceptibility to traffic-related air pollution. Part Fibre Toxicol. 2012;15:9-43.
Not in our library10.1186/1743-8977-9-43
- 21.
Savov JD, Whitehead GS, Wang J, Liao G, Usuka J, Peltz G, et al. Ozone-induced acute pulmonary injury in inbred mouse strains. Am J Respir Cell Mol Biol. 2004;31:61-7.
Not in our library10.1165/rcmb.2003-0001oc
- 22.
Laumbach RJ, Kipen HM. Respiratory health effects of air pollution: update on biomass smoke and traffic pollution. J Allergy Clin Immunol. 2012;129:3-11.
Not in our library10.1016/j.jaci.2011.11.021
- 23.
Lundborg M, Johard U, Låstbom L, Gerde P, Camner P. Human alveolar macrophage phagocytic function is impaired by aggregates of ultrafine carbon particles. Environ Res. 2001;86:244-53.
Not in our library10.1006/enrs.2001.4269
- 24.
Stearns RC, Paulauskis JD, Godleski JJ. Endocytosis of ultrafine particles by A549 cells. Am J Respir Cell Mol Biol. 2001;24:108-15.
Not in our library10.1165/ajrcmb.24.2.4081
- 25.
Baulig A, Garlatti M, Bonvallot V, Marchand A, Barouki R, Marano F, et al. Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2003;285:L671-9.
Not in our library10.1152/ajplung.00419.2002
- 26.
Nel AE, Diaz-Sanchez D, Li N. The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress. Curr Opin Pulm Med. 2001;7:20-6.
Not in our library10.1097/00063198-200101000-00004
- 27.
Bayram H, Ito K, Issa R, Ito M, Sukkar M, Chung KF. Regulation of human lung epithelial cell numbers by diesel exhaust particles. Eur Respir J. 2006;27:705-13.
Not in our library10.1183/09031936.06.00012805
- 28.
Wu W, Samet JM, Ghio AJ, Devlin RB. Activation of the EGF receptor signaling pathway in airway epithelial cells exposed to Utah Valley PM. Am J Physiol Lung Cell Mol Physiol. 2001;281:483-9.
Not in our library10.1152/ajplung.2001.281.2.l483
- 29.
Sakamoto N, Hayashi S, Gosselink J, Ishii H, Ishimatsu Y, Mukae H, et al. Calcium dependent and independent cytokine synthesis by air pollution particle-exposed human bronchial epithelial cells. Toxicol Appl Pharmacol. 2007;225:134-41.
Not in our library10.1016/j.taap.2007.07.006
- 30.
Devlin RB, McKinnon KP, Noah T, Becker S, Koren HS. Ozone-induced release of cytokines and fibronectin by alveolar macrophages in vitro. Am J Physiol. 1994;266:612-9.
Not in our library10.1152/ajplung.1994.266.6.l612
- 31.
Koike E, Watanabe H, Kobayashi T. Exposure to ozone enhances antigen-presenting activity concentration dependently in rats. Toxicology. 2004;197:37-46.
Not in our library10.1016/j.tox.2003.12.007
- 32.
Koike E, Hirano S, Shimojo N, Kobayashi T. cDNA microarray analysis of gene expression in rat alveolar macrophages in response to organic extract of diesel exhaust particles. Toxicol Sci. 2002;67:241-6.
Not in our library10.1093/toxsci/67.2.241
- 33.
Timblin CR, Shukla A, Berlanger I, BeruBe KA, Churg A, Mossman BT. Ultrafine airborne particles cause increases in protooncogene expression and proliferation in alveolar epithelial cells. Toxicol Appl Pharmacol. 2002;179:98-104.
Not in our library10.1006/taap.2001.9343
- 34.
Li N, Wang M, Oberley TD, Sempf JM, Nel AE. Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. J Immunol. 2002;169:4531-41.
Not in our library10.4049/jimmunol.169.8.4531
- 35.
Bayram H, Fakili F, Gögebakan B, Bayraktar R, Öztuzcu S, Dikensoy Ö, et al. Effect of serum on diesel exhaust particles (DEP)-induced apoptosis of airway epithelial cells in vitro. Toxicol Lett. 2013;218:215-23.
Not in our library10.1016/j.toxlet.2013.02.006
- 36.
Bayram H, Göğebakan B, Dikensoy O, Güldal S, Ekinci E. Effects of diesel exhaust particles on viability of primary bronchial epithelial cells of non-smokers, smokers and patients with COPD. Am J Respir Crit Care Med. 2009;179:A3162 (Abst).
Not in our library
- 37.
Cecchi L, D’Amato G, Annesi-Maesano I. Climate, urban air pollution, and respiratory allergy. Reference Module in Earth Systems and Environmental Sciences, from Climate Vulnerability, Volume 1. Elsevier; 2013. p. 105–13. Current as of 24 March 2014.
Not in our library
- 38.
Bentayeb M, Simoni M, Baiz N, Norback D, Baldacci S, Maio S, et al. Geriatric study in Europe on health effects of air quality in nursing homes group. Adverse respiratory effects of outdoor air pollution in the elderly. Int J Tuberc Lung Dis. 2012;16:1149-61.
Not in our library10.5588/ijtld.11.0666
- 39.
Perez L, Declercq C, Iñiguez C, Aguilera I, Badaloni C, Ballester F, et al. Chronic burden of near-roadway traffic pollution in 10 European cities (APHEKOM network). EurRespir J. 2013;42:594-605.
Not in our library10.1183/09031936.00031112
- 40.
Hulin M, Simoni M, Viegi G, Annesi-Maesano I. Respiratory health and indoor air pollutants based on quantitative exposure assessments. EurRespir J. 2012;40:1033-45.
Not in our library10.1183/09031936.00159011
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