Clinical use of lactate monitoring in critically ill patients

Abstract

Increased blood lactate levels (hyperlactataemia) are common in critically ill patients. Although frequently used to diagnose inadequate tissue oxygenation, other processes not related to tissue oxygenation may increase lactate levels. Especially in critically ill patients, increased glycolysis may be an important cause of hyperlactataemia. Nevertheless, the presence of increased lactate levels has important implications for the morbidity and mortality of the hyperlactataemic patients. Although the term lactic acidosis is frequently used, a significant relationship between lactate and pH only exists at higher lactate levels. The term lactate associated acidosis is therefore more appropriate. Two recent studies have underscored the importance of monitoring lactate levels and adjust treatment to the change in lactate levels in early resuscitation. As lactate levels can be measured rapidly at the bedside from various sources, structured lactate measurements should be incorporated in resuscitation protocols.

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Cited by papers we hold 3

• Tissue oxygen saturation changes and postoperative complications in cardiac surgery: a prospective observational study · 2019
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• A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals · 2019
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• Hemodynamic consequences of severe lactic acidosis in shock states: from bench to bedside · 2015
  Corrected

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