What brain signals are suitable for feedback control of deep brain stimulation in Parkinson's disease?

Abstract

Feedback control of deep brain stimulation (DBS) in Parkinson's disease has great potential to improve efficacy, reduce side effects, and decrease the cost of treatment. In this, the timing and intensity of stimulation are titrated according to biomarkers that capture current clinical state. Stimulation may be at standard high frequency or intelligently patterned to directly modify specific pathological rhythms. The search for and validation of appropriate feedback signals are therefore crucial. Signals recorded from the DBS electrode currently appear to be the most promising source of feedback. In particular, beta‐frequency band oscillations in the local field potential recorded at the stimulation target may capture variation in bradykinesia and rigidity across patients, but this remains to be confirmed within patients. Biomarkers that reliably reflect other impairments, such as tremor, also need to be established. Finally, whether brain signals are causally important needs to be established before stimulation can be specifically patterned rather than delivered at empirically defined high frequency.

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References 88

1. 1.
   Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): a randomised, open-label trial · 2010

   No notice
2. 2.

   Chen CC, et al. Deep brain stimulation of the subthalamic nucleus: a two-edged sword. Curr. Biol. 2006;16:952-953.

   Not in our library10.1016/j.cub.2006.10.013

3. 3.

   Morrell MJ. Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology. 2011;77:1295-304.

   Not in our library10.1212/wnl.0b013e3182302056

4. 4.

   Fisher R, et al. Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy. Epilepsia. 2010;51:899-908.

   Not in our library10.1111/j.1528-1167.2010.02536.x

5. 5.

   Jobst BC, Darcey TM, Thadani VM, Roberts DW. Brain stimulation for the treatment of epilepsy. Epilepsia. 2010;51(Suppl 3):88-92.

   Not in our library10.1111/j.1528-1167.2010.02618.x

6. 6.

   Sutton R, Fisher JD, Linde C, Benditt DG. History of electrical therapy for the heart. Eur. Heart J. Suppl. 2007;9:I3-I10.

   Not in our library

7. 7.

   Rivlin-Etzion M, et al. Basal ganglia oscillations and pathophysiology of movement disorders. Curr. Opin. Neurobiol. 2006;16:629-637.

   Not in our library10.1016/j.conb.2006.10.002

8. 8.

   Brown P. Oscillatory nature of human basal ganglia activity: relationship to the pathophysiology of Parkinson's disease. Movement Disord. 2003;18:357-363.

   Not in our library10.1002/mds.10358

9. 9.

   Rossi L, et al. An electronic device for artefact suppression in human local field potential recordings during deep brain stimulation. J. Neural Eng. 2007;4:96-106.

   Not in our library10.1088/1741-2560/4/2/010

10. 10.

    Eusebio A, et al. Deep brain stimulation can suppress pathological synchronisation in parkinsonian patients. J. Neurol. Neurosurg. Psychiatr. 2011;82:569-573.

    Not in our library10.1136/jnnp.2010.217489

11. 11.

    Curran EA, Stokes MJ. Learning to control brain activity: a review of the production and control of EEG components for driving brain-computer interface (BCI) systems. Brain Cogn. 2003;51:326-336.

    Not in our library10.1016/s0278-2626(03)00036-8

12. 12.

    Müller V, Lutzenberger W, Pulvermüller F, et al. Investigation of brain dynamics in Parkinson's disease by methods derived from nonlinear dynamics. Exp. Brain Res. 2001;137:103-110.

    Not in our library10.1007/s002210000638

13. 13.

    Pezard L. Investigation of non-linear properties of multichannel EEG in the early stages of Parkinson's disease. Clin. Neurophysiol. 2001;112:38-45.

    Not in our library10.1016/s1388-2457(00)00512-5

14. 14.

    Silberstein P, et al. Cortico-cortical coupling in Parkinson's disease and its modulation by therapy. Brain. 2005;128:1277-1291.

    Not in our library10.1093/brain/awh480

15. 15.

    Stoffers D, et al. Increased cortico-cortical functional connectivity in early-stage Parkinson's disease: an MEG study. Neuro Image. 2008;41:212-222.

    Not in our library10.1016/j.neuroimage.2008.02.027

16. 16.

    Schwartz AB, Cui XT, Weber DJ, Moran DW. Brain-controlled interfaces: movement restoration with neural prosthetics. Neuron. 2006;52:205-220.

    Not in our library10.1016/j.neuron.2006.09.019

17. 17.

    Weinberger M, et al. Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease. J. Neurophysiol. 2006;96:3248-3256.

    Not in our library10.1152/jn.00697.2006

18. 18.

    Moran A, Bergman H, Israel Z, Bar-Gad I. Subthalamic nucleus functional organization revealed by parkinsonian neuronal oscillations and synchrony. Brain. 2008;131:3395-409.

    Not in our library10.1093/brain/awn270

19. 19.

    Kilpatrick M, et al. Intracerebral microdialysis during deep brain stimulation surgery. J. Neurosci. Methods. 2010;190:106-111.

    Not in our library10.1016/j.jneumeth.2010.04.013

20. 20.

    Shon Y, et al. High frequency stimulation of the subthalamic nucleus evokes striatal dopamine release in a large animal model of human DBS neurosurgery. Neurosci. Lett. 2010;475:136-140.

    Not in our library10.1016/j.neulet.2010.03.060

21. 21.

    Kühn AA, et al. The relationship between local field potential and neuronal discharge in the subthalamic nucleus of patients with Parkinson's disease. Exp. Neurol. 2005;194:212-220.

    Not in our library10.1016/j.expneurol.2005.02.010

22. 22.

    Andersen R, Musallam S, Pesaran B. Selecting the signals for a brain-machine interface. Curr. Opin. Neurobiol. 2004;14:720-726.

    Not in our library10.1016/j.conb.2004.10.005

23. 23.

    Kühn AA, Kupsch A, Schneider G, Brown P. Reduction in subthalamic 8–35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease. Eur. J. Neurosci. 2006;23:1956-1960.

    Not in our library10.1111/j.1460-9568.2006.04717.x

24. 24.

    Kühn AA, et al. Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity. Exp. Neurol. 2009;215:380-387.

    Not in our library10.1016/j.expneurol.2008.11.008

25. 25.

    Ray NJ, et al. Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation. Exp. Neurol. 2008;213:108-113.

    Not in our library10.1016/j.expneurol.2008.05.008

26. 26.

    Kühn AA, et al. High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson's disease in parallel with improvement in motor performance. J. Neurosci. 2008;28:6165-6173.

    Not in our library10.1523/jneurosci.0282-08.2008

27. 27.

    Bronte-Stewart H, et al. The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation. Exp. Neurol. 2009;215:20-28.

    Not in our library10.1016/j.expneurol.2008.09.008

28. 28.

    Foffani G, et al. Subthalamic oscillatory activities at beta or higher frequency do not change after high-frequency DBS in Parkinson's disease. Brain Res. Bull. 2006;69:123-130.

    Not in our library10.1016/j.brainresbull.2005.11.012

29. 29.

    Rossi L, et al. Subthalamic local field potential oscillations during ongoing deep brain stimulation in Parkinson's disease. Brain Res. Bull. 2008;76:512-521.

    Not in our library10.1016/j.brainresbull.2008.01.023

30. 30.

    Wingeier B, et al. Intra-operative STN DBS attenuates the prominent beta rhythm in the STN in Parkinson's disease. Exp. Neurol. 2006;197:244-251.

    Not in our library10.1016/j.expneurol.2005.09.016

31. 31.

    Rosa M, et al. Subthalamic local field beta oscillations during ongoing deep brain stimulation in Parkinson's disease in hyperacute and chronic phases. Neuro-Signals. 2011;19:151-162.

    Not in our library10.1159/000328508

32. 32.

    Rosa M, et al. Time dependent subthalamic local field potential changes after DBS surgery in Parkinson's disease. Exp. Neurol. 2010;222:184-190.

    Not in our library10.1016/j.expneurol.2009.12.013

33. 33.

    Amirnovin R, Williams ZM, Cosgrove GR, Eskandar EN. Visually guided movements suppress subthalamic oscillations in Parkinson's disease patients. J. Neurosci. 2004;24:11302-11306.

    Not in our library10.1523/jneurosci.3242-04.2004

34. 34.

    Cassidy M, et al. Movement-related changes in synchronization in the human basal ganglia. Brain. 2002;125:1235-1246.

    Not in our library10.1093/brain/awf135

35. 35.

    Levy R. Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease. Brain. 2002;125:1196-1209.

    Not in our library10.1093/brain/awf128

36. 36.

    Alegre M, et al. Movement-related changes in cortical oscillatory activity in ballistic, sustained and negative movements. Exp. Brain Res. 2003;148:17-25.

    Not in our library10.1007/s00221-002-1255-x

37. 37.

    Androulidakis AG, et al. Amplitude modulation of oscillatory activity in the subthalamic nucleus during movement. Eur. J. Neurosci. 2008;27:1277-1284.

    Not in our library10.1111/j.1460-9568.2008.06085.x

38. 38.

    Foffani G, Bianchi A, Baselli G, Priori A. Movement-related frequency modulation of beta oscillatory activity in the human subthalamic nucleus. J. Physiol. 2005;568:699-711.

    Not in our library10.1113/jphysiol.2005.089722

39. 39.

    Urrestarazu E, et al. Beta activity in the subthalamic nucleus during sleep in patients with Parkinson's disease. Movement Disord. 2009;24:254-260.

    Not in our library10.1002/mds.22351

40. 40.

    De Cock VC, et al. Restoration of normal motor control in Parkinson's disease during REM sleep. Brain. 2007;130:450-456.

    Not in our library10.1093/brain/awl363

41. 41.

    Brown P, et al. Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease. J. Neurosci. 2001;21:1033-1038.

    Not in our library10.1523/jneurosci.21-03-01033.2001

42. 42.

    Fogelson N, et al. Reciprocal interactions between oscillatory activities of different frequencies in the subthalamic region of patients with Parkinson's disease. Eur. J. Neurosci. 2005;22:257-266.

    Not in our library10.1111/j.1460-9568.2005.04179.x

43. 43.

    Levy R, Hutchison WD, Lozano AM, Dostrovsky JO. High-frequency synchronization of neuronal activity in the subthalamic nucleus of parkinsonian patients with limb tremor. J. Neurosci. 2000;20:7766-7775.

    Not in our library10.1523/jneurosci.20-20-07766.2000

44. 44.

    Reck C, et al. Characterisation of tremor-associated local field potentials in the subthalamic nucleus in Parkinson's disease. Eur. J. Neurosci. 2009;29:599-612.

    Not in our library10.1111/j.1460-9568.2008.06597.x

45. 45.

    Timmermann L, et al. The cerebral oscillatory network of parkinsonian resting tremor. Brain. 2003;126:199-212.

    Not in our library10.1093/brain/awg022

46. 46.

    Tass P, et al. The causal relationship between subcortical local field potential oscillations and Parkinsonian resting tremor. J. Neural Eng. 2010;7:16009.

    Not in our library10.1088/1741-2560/7/1/016009

47. 47.

    Wang S, et al. Revealing the dynamic causal interdependence between neural and muscular signals in Parkinsonian tremor. J. Franklin Institute. 2007;344:180-195.

    Not in our library

48. 48.

    Alonso-Frech F, et al. Slow oscillatory activity and levodopa-induced dyskinesias in Parkinson's disease. Brain. 2006;129:1748-1757.

    Not in our library10.1093/brain/awl103

49. 49.

    Silberstein P, et al. Oscillatory pallidal local field potential activity inversely correlates with limb dyskinesias in Parkinson's disease. Exp. Neurol. 2005;194:523-529.

    Not in our library10.1016/j.expneurol.2005.03.014

50. 50.

    Stefani A, et al. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease. Brain. 2007;130:1596-1607.

    Not in our library10.1093/brain/awl346

51. 51.

    Weinberger M, et al. Pedunculopontine nucleus microelectrode recordings in movement disorder patients. Exp. Brain Res. 2008;188:165-174.

    Not in our library10.1007/s00221-008-1349-1

52. 52.

    Androulidakis AG, et al. Oscillatory activity in the pedunculopontine area of patients with Parkinson's disease. Exp. Neurol. 2008;211:59-66.

    Not in our library10.1016/j.expneurol.2008.01.002

53. 53.

    Friston KJ. The labile brain: I. Neuronal transients and nonlinear coupling. Philos. Trans. R. Soc. Lond. B. 2000;355:215-236.

    Not in our library10.1098/rstb.2000.0560

54. 54.

    Stam C. Nonlinear dynamical analysis of EEG and MEG: review of an emerging field. Clin. Neurophysiol. 2005;116:2266-2301.

    Not in our library10.1016/j.clinph.2005.06.011

55. 55.

    Bassett DS, Gazzaniga MS. Understanding complexity in the human brain. Trends Cogn. Sci. 2011;15:200-209.

    Not in our library10.1016/j.tics.2011.03.006

56. 56.

    Chen CC, et al. Complexity of subthalamic 13–35 Hz oscillatory activity directly correlates with clinical impairment in patients with Parkinson's disease. Exp. Neurol. 2010;224:234-240.

    Not in our library10.1016/j.expneurol.2010.03.015

57. 57.
    Beta band stability over time correlates with Parkinsonian rigidity and bradykinesia · 2012

    No notice
58. 58.

    Marceglia S, et al. Dopamine-dependent non-linear correlation between subthalamic rhythms in Parkinson's disease. J. Physiol. 2006;571:579-591.

    Not in our library10.1113/jphysiol.2005.100271

59. 59.

    López-Azcárate J, et al. Coupling between beta and high-frequency activity in the human subthalamic nucleus may be a pathophysiological mechanism in Parkinson's disease. J. Neurosci. 2010;30:6667-6677.

    Not in our library10.1523/jneurosci.5459-09.2010

60. 60.

    Ozkurt TE, et al. High frequency oscillations in the subthalamic nucleus: a neurophysiological marker of the motor state in Parkinson's disease. Exp. Neurol. 2011;229:324-331.

    Not in our library10.1016/j.expneurol.2011.02.015

61. 61.

    Pogosyan A, et al. Parkinsonian impairment correlates with spatially extensive subthalamic oscillatory synchronization. Neuroscience. 2010;171:245-257.

    Not in our library10.1016/j.neuroscience.2010.08.068

62. 62.

    Fries P. A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Trends Cogn. Sci. 2005;9:474-480.

    Not in our library10.1016/j.tics.2005.08.011

63. 63.

    De Solages C, Hill BC, Koop MM, et al. Bilateral symmetry and coherence of subthalamic nuclei beta band activity in Parkinson's disease. Exp. Neurol. 2010;221:260-266.

    Not in our library10.1016/j.expneurol.2009.11.012

64. 64.

    Litvak V, et al. Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease. Brain. 2011;134:359-374.

    Not in our library10.1093/brain/awq332

65. 65.

    Kühn AA, et al. Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance. Brain. 2004;127:735-746.

    Not in our library10.1093/brain/awh106

66. 66.

    Williams D, et al. Dopamine-dependent changes in the functional connectivity between basal ganglia and cerebral cortex in humans. Brain. 2002;125:1558-1569.

    Not in our library10.1093/brain/awf156

67. 67.
    EEGLAB, SIFT, NFT, BCILAB, and ERICA: New Tools for Advanced EEG Processing · 2011

    No notice
68. 68.

    Deuschl G, Raethjen J, Hellriegel H, Elble R. Treatment of patients with essential tremor. Lancet Neurol. 2011;10:148-161.

    Not in our library10.1016/s1474-4422(10)70322-7

69. 69.

    Allen D, et al. On the use of low-cost computer peripherals for the assessment of motor dysfunction in Parkinson's disease—quantification of bradykinesia using target tracking tasks. Neural Syst. Rehab. Eng. IEEE Trans. 2007;15:286-294.

    Not in our library10.1109/tnsre.2007.897020

70. 70.

    Kim J, et al. Quantification of bradykinesia during clinical finger taps using a gyrosensor in patients with Parkinson's disease. Med. Biol. Eng. Comput. 2011;49:365-371.

    Not in our library10.1007/s11517-010-0697-8

71. 71.

    Prochazka A, et al. Measurement of rigidity in Parkinson's disease. Movement Disord. 1997;12:24-32.

    Not in our library10.1002/mds.870120106

72. 72.

    Endo T, Okuno R, Yokoe M, et al. A novel method for systematic analysis of rigidity in Parkinson's disease. Movement Disord. 2009;24:2218-2224.

    Not in our library10.1002/mds.22752

73. 73.

    Schiff SJ. Towards model-based control of Parkinson's disease. Philos. Trans. 2010;368:2269-2308.

    Not in our library10.1098/rsta.2010.0050

74. 74.

    Feng X, Greenwald B, Rabitz H, et al. Toward closed-loop optimization of deep brain stimulation for Parkinson's disease: concepts and lessons from a computational model. J. Neural Eng. 2007;4:14-21.

    Not in our library10.1088/1741-2560/4/2/l03

75. 75.

    Feng X, Shea-Brown E, Greenwald B, et al. Optimal deep brain stimulation of the subthalamic nucleus—a computational study. J. Comput. Neurosci. 2007;23:265-282.

    Not in our library10.1007/s10827-007-0031-0

76. 76.

    Rosin B, et al. Closed-loop deep brain stimulation is superior in ameliorating parkinsonism. Neuron. 2011;72:370-384.

    Not in our library10.1016/j.neuron.2011.08.023

77. 77.

    Jensen S, et al. Information, energy, and entropy: design principles for adaptive, therapeutic modulation of neural circuits. Solid-State Circuits Conf. 2008. 2008;32-39.

    Not in our library

78. 78.

    Stanslaski S, et al. An implantable bi-directional brain-machine interface system for chronic neuroprosthesis research. Conf. Proc.: Annu. Int. Conf. IEEE Eng. Med. Biol. Soc. 2009;2009:5494-5497.

    Not in our library10.1109/iembs.2009.5334562

79. 79.

    Silberstein P, et al. Patterning of globus pallidus local field potentials differs between Parkinson's disease and dystonia. Brain. 2003;126:2597-2608.

    Not in our library10.1093/brain/awg267

80. 80.

    Priori A, et al. Rhythm-specific pharmacological modulation of subthalamic activity in Parkinson's disease. Exp. Neurol. 2004;189:369-379.

    Not in our library10.1016/j.expneurol.2004.06.001

81. 81.

    Doyle LMF, et al. Levodopa-induced modulation of subthalamic beta oscillations during self-paced movements in patients with Parkinson's disease. Eur. J. Neurosci. 2005;21:1403-1412.

    Not in our library10.1111/j.1460-9568.2005.03969.x

82. 82.

    Kühn AA, et al. Modulation of beta oscillations in the subthalamic area during motor imagery in Parkinson's disease. Brain. 2006;129:695-706.

    Not in our library10.1093/brain/awh715

83. 83.

    Timmermann L, et al. Ten-Hertz stimulation of subthalamic nucleus deteriorates motor symptoms in Parkinson's disease. Movement Disord. 2004;19:1328-1333.

    Not in our library10.1002/mds.20198

84. 84.

    Fogelson N, et al. Frequency dependent effects of subthalamic nucleus stimulation in Parkinson's disease. Neurosci. Lett. 2005;382:5-9.

    Not in our library10.1016/j.neulet.2005.02.050

85. 85.

    Chen CC, et al. Stimulation of the subthalamic region at 20Hz slows the development of grip force in Parkinson's disease. Exp. Neurol. 2011;231:91-96.

    Not in our library10.1016/j.expneurol.2011.05.018

86. 86.
    Effects of low-frequency stimulation of the subthalamic nucleus on movement in Parkinson's disease · 2008

    No notice
87. 87.

    Little S, et al. A torque-based method demonstrates increased rigidity in Parkinson's disease during low-frequency stimulation. Exp. Brain Res. 2012.

    Not in our library10.1007/s00221-012-3107-7

88. 88.

    Zaidel A, Spivak A, Grieb B, et al. Subthalamic span of beta oscillations predicts deep brain stimulation efficacy for patients with Parkinson's disease. Brain. 2010;133:2007-2021.

    Not in our library10.1093/brain/awq144

Cited by papers we hold 5

• Advances in closed-loop deep brain stimulation devices · 2017
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• The modulatory effect of adaptive deep brain stimulation on beta bursts in Parkinson’s disease · 2017
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• Adaptive Deep Brain Stimulation for Movement Disorders: The Long Road to Clinical Therapy · 2017
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• Closed-Loop Neuroscience and Non-Invasive Brain Stimulation: A Tale of Two Loops · 2016
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• Closed-loop Neurostimulation: The Clinical Experience · 2014
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