Osteochondral tissue engineering: scaffolds, stem cells and applications

Abstract

Osteochondral tissue engineering has shown an increasing development to provide suitable strategies for the regeneration of damaged cartilage and underlying subchondral bone tissue. For reasons of the limitation in the capacity of articular cartilage to self‐repair, it is essential to develop approaches based on suitable scaffolds made of appropriate engineered biomaterials. The combination of biodegradable polymers and bioactive ceramics in a variety of composite structures is promising in this area, whereby the fabrication methods, associated cells and signalling factors determine the success of the strategies. The objective of this review is to present and discuss approaches being proposed in osteochondral tissue engineering, which are focused on the application of various materials forming bilayered composite scaffolds, including polymers and ceramics, discussing the variety of scaffold designs and fabrication methods being developed. Additionally, cell sources and biological protein incorporation methods are discussed, addressing their interaction with scaffolds and highlighting the potential for creating a new generation of bilayered composite scaffolds that can mimic the native interfacial tissue properties, and are able to adapt to the biological environment.

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References 146

1. 1.

   Spalazzi JP, Doty SB, Moffat KL, et al. Development of controlled matrix heterogeneity on a triphasic scaffold for orthopedic interface tissue engineering. Tissue Eng. 2006;12:12.

   Not in our library10.1089/ten.2006.12.3497

2. 2.

   Martin I, Miot S, Barbero A, et al. Osteochondral tissue engineering. J Biomech. 2007;40:750-65.

   Not in our library10.1016/j.jbiomech.2006.03.008

3. 3.

   Lu HH, Subramony SD, Boushell MK, et al. Tissue engineering strategies for the regeneration of orthopedic interface. Ann Biomed Eng. 2010;38:2142-54.

   Not in our library10.1007/s10439-010-0046-y

4. 4.

   Yang PJ, Johnna S. Engineering orthopedic tissue interface. Tissue eng: Part B. 2009;15:2.

   Not in our library10.1089/ten.teb.2008.0371

5. 5.

   Keeney M, Pandit A. The osteochondral junction and its repair via biphasic tissue engineering scaffolds. Tissue Eng: Part B. 2009;15:1.

   Not in our library10.1089/ten.teb.2008.0388

6. 6.

   Arvidson K, Abdallah BM, Applegate LA, et al. Bone regeneration and stem cells. J Cell Mol Med. 2011;15:718-46.

   Not in our library10.1111/j.1582-4934.2010.01224.x

7. 7.

   Stoop R. Smart biomaterials for tissue engineering of cartilage. Injury Int J Care Injured. 2008;39S1:77-87.

   Not in our library10.1016/j.injury.2008.01.036

8. 8.

   Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthr Cartilage. 2001;10:432-63.

   Not in our library10.1053/joca.2002.0801

9. 9.

   Timonthy MO, Xigeng M. Bilayered scaffolds for osteochondral tissue engineering. Tissue Eng: Part B. 2008;14:4.

   Not in our library10.1089/ten.teb.2008.0327

10. 10.

    Mano JF, Reis RL. Osteochondral defects: present situation and tissue engineering approaches. J Tissue Eng Regen Med. 2007;1:261-73.

    Not in our library10.1002/term.37

11. 11.

    Tuli R, Li WJ, Tuan RS. Current state of cartilage tissue engineering. Arthritis Res Ther. 2003;5:235-8.

    Not in our library10.1186/ar991

12. 12.

    Hutmacher DW. Scaffolds in tissue engineering bone and cartilage. Biomaterials. 2000;21:2529-43.

    Not in our library10.1016/s0142-9612(00)00121-6

13. 13.

    Sharma B, Elisseeff JH. Engineering structurally organized cartilage and bone tissues. Ann Biomed Eng. 2004;32:148-59.

    Not in our library10.1023/b:abme.0000007799.60142.78

14. 14.

    Beris AE, Lykissas MG, Papageorgiou CD, et al. Advances in articular cartilage repair. Injury Int J Care Injured. 2005;36:14-23.

    Not in our library10.1016/j.injury.2005.10.007

15. 15.

    Puppi D, Chiellini F, Piras AM, et al. Polymeric materials for bone and cartilage repair. Prog Polym Sci. 2010;35:403-40.

    Not in our library

16. 16.

    Mano JF, Silva GA, Azevedo HS, et al. Natural origin biodegradable systems in tissue engineering and regenerative medicine: present status and some moving trends. J R Soc Interface. 2007;4:999-1030.

    Not in our library10.1098/rsif.2007.0220

17. 17.

    Bonzani IC, George JH, Stevens MM. Novel materials for bone and cartilage regeneration. Curr Opin Chem Biol. 2006;10:568-75.

    Not in our library10.1016/j.cbpa.2006.09.009

18. 18.

    Frenkel SR, Toolan B, Menche D, et al. Chondrocyte transplantation using a collagen bilayered matrix for cartilage repair. J Bone Joint Surg. 1997;79B:831-6.

    Not in our library10.1302/0301-620x.79b5.7278

19. 19.

    Chung C, Burdick JA. Engineering cartilage tissue. Adv Drug Deliver Rev. 2008;60:243-62.

    Not in our library10.1016/j.addr.2007.08.027

20. 20.

    Chen QZ, Thompson ID, Boccaccini AR. 45S5 Bioglass®-derived glass-ceramic scaffolds for bone tissue engineering. Biomaterials. 2006;27:2414-25.

    Not in our library10.1016/j.biomaterials.2005.11.025

21. 21.

    Patel N, Best SM, Bonfield W, et al. A comparison study on the in vivo behavior of hydroxyapatite and silicon substituted hydroxyapatite granules. Mater Med. 2002;13:1199-206.

    Not in our library10.1023/a:1021114710076

22. 22.

    Leukers B, Lkan HLG, Irsen SH, et al. Hydroxyapatite scaffolds for bone tissue engineering made by 3D printing. J Mater Sci Mater Med. 2005;16:1121-4.

    Not in our library10.1007/s10856-005-4716-5

23. 23.

    Kokubo T. Bioactive glass ceramics: properties and applications. Biomaterials. 1991;12:155.

    Not in our library10.1016/0142-9612(91)90194-f

24. 24.

    Hench LL. Bioactive ceramics. Ann NY Acad Sci. 2006;523:1.

    Not in our library10.1111/j.1749-6632.1988.tb38500.x

25. 25.

    Lima EG, Mauck RL, Han SH, et al. Functional tissue engineering of chondral and osteochondral constructs. Biorheology. 2004;41:577-90.

    Not in our library

26. 26.

    Bal BS, Rahaman MN, Jayabalan P, et al. In vivo outcomes of tissue-engineered osteochondral grafts. J Biomed Mater Res Part B: Appl Biomater. 2010;93B:164-74.

    Not in our library10.1002/jbm.b.31571

27. 27.

    Frosch KH, Drengk A, Krause P, et al. Stem cell-coated titanium implants for the partial joint resurfacing of the knee. Biomaterials. 2006;27:2542-2549.

    Not in our library10.1016/j.biomaterials.2005.11.034

28. 28.

    Richardson SM, Hoyland JA, Mobasheri R, et al. Mesenchymal Stem Cells in Regenerative Medicine: opportunities and Challenges for Articular Cartilage and Intervertebral Disc Tissue Engineering. J Cell Physiol. 2010;222:23-32.

    Not in our library10.1002/jcp.21915

29. 29.

    Mueller MB, Tuan RS. Functional Characterization of Hypertrophy in Chondrogenesis of Human Mesenchymal Stem Cells. Arthritis Rheum. 2008;58:1377-88.

    Not in our library10.1002/art.23370

30. 30.

    Petrenko YA, Ivanov RV, Petrenko AY, et al. Coupling of gelatin to inner surfaces of pore walls in spongy alginate-based scaffolds facilitates the adhesion, growth and differentiation of human bone marrow mesenchymal stromal cells. J Mater Sci: Mater Med. 2011;22:1529-40.

    Not in our library10.1007/s10856-011-4323-6

31. 31.

    Wang Y, Bian YZ, Wu Q, et al. Evaluation of three-dimentional scaffolds prepared from poly(3-hydroxybutyrate-co-3-hydroxy-hexanoate) for growth of allogeneic chondrocytes for cartilage repair in rabbits. Biomaterials. 2008;29:2858-68.

    Not in our library10.1016/j.biomaterials.2008.03.021

32. 32.

    Alves da Silva ML, Crawford A, Mundy JM, et al. Chitosan/polyester-based scaffolds for cartilage tissue engineering: assessment of extracellular matrix formation. Acta Biomater. 2010;6:1149-57.

    Not in our library10.1016/j.actbio.2009.09.006

33. 33.

    Malafaya PB, Pedro AJ, Peterbauer A, et al. Chitosan particles agglomerated scaffolds for cartilage and osteochondral tissue engineering approaches with adipose tissue derived stem cells. J Mater Sci-Mater Med. 2005;16:1077-85.

    Not in our library10.1007/s10856-005-4709-4

34. 34.

    Malafaya PB, Reis RL. Bilayered chitosan-based scaffolds for osteochondral tissue engineering: influence of hydroxyapatite on in vitro cytotoxicity and dynamic bioactivity studies in a specific double-chamber bioreactor. Acta Biomater. 2009;5:644-60.

    Not in our library10.1016/j.actbio.2008.09.017

35. 35.

    Chajra H, Rousseau CF, Cortial D, et al. Collagen-based biomaterials and cartilage engineering. Application to osteochondral defects. Biomed Mater Eng. 2008;18:33-45.

    Not in our library

36. 36.

    Galois L, Freyria AM, Grossin L, et al. Cartilage repair: surgical techniques and tissue engineering using polysaccharide- and collagen-based biomaterials. Biorheology. 2004;41:433-43.

    Not in our library

37. 37.

    Shafiee A, Soleimani M, Chamheidari GA, et al. Electrospun nanofiber-based regeneration of cartilage enhanced by mesenchymal stem cells. J Biomed Mater Res, Part A. 2011;99A:467-78.

    Not in our library10.1002/jbm.a.33206

38. 38.

    Huang X, Yang D, Yan W, et al. Osteochondral repair using the combination of fibroblast growth factor and amorphous calcium phosphate/poly(L-lactic acid) hybrid materials. Biomaterials. 2007;28:3091-100.

    Not in our library10.1016/j.biomaterials.2007.03.017

39. 39.

    Blaker JJ, Maquet V, Jérôme R, et al. Mechanical properties of highly porous PDLLA/Bioglass composite foams as scaffolds for bone tissue engineering. Acta Biomater. 2005;1:643-52.

    Not in our library10.1016/j.actbio.2005.07.003

40. 40.

    Ngiam M, Liao S, Patil AJ, et al. The fabrication of nano-hydroxyapatite on PLGA and PLGA/collagen nanofibrous composite scaffolds and their effects in osteoblastic behavior for bone tissue engineering. Bone. 2009;45:4-16.

    Not in our library10.1016/j.bone.2009.03.674

Cited by papers we hold 7

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• Silk fibroin-based biomaterials for cartilage/osteochondral repair · 2022
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• Osteochondral Injury, Management and Tissue Engineering Approaches · 2020
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• Ex vivo MRI cell tracking of autologous mesenchymal stromal cells in an ovine osteochondral defect model · 2019
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• Differential chondro- and osteo-stimulation in three-dimensional porous scaffolds with different topological surfaces provides a design strategy for biphasic osteochondral engineering · 2019
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• Bone biomaterials and interactions with stem cells · 2017
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• The use of PLDLA/PCL-T scaffold to repair osteochondral defects in vivo · 2012
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