Parkinson's disease as a result of aging

Abstract

Summary It is generally considered that Parkinson's disease is induced by specific agents that degenerate a clearly defined population of dopaminergic neurons. Data commented in this review suggest that this assumption is not as clear as is often thought and that aging may be critical for Parkinson's disease. Neurons degenerating in Parkinson's disease also degenerate in normal aging, and the different agents involved in the etiology of this illness are also involved in aging. Senescence is a wider phenomenon affecting cells all over the body, whereas Parkinson's disease seems to be restricted to certain brain centers and cell populations. However, reviewed data suggest that Parkinson's disease may be a local expression of aging on cell populations which, by their characteristics (high number of synaptic terminals and mitochondria, unmyelinated axons, etc.), are highly vulnerable to the agents promoting aging. The development of new knowledge about Parkinson's disease could be accelerated if the research on aging and Parkinson's disease were planned together, and the perspective provided by gerontology gains relevance in this field.

References 388

1. 1.

   Abeliovich A, Schmitz Y, Farinas I, Choi-Lundberg D, Ho WH, Castillo PE, Shinsky N, Verdugo JM, Armanini M, Ryan A, Hynes M, Phillips H, Sulzer D, Rosenthal A. Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron. 2000;25:239-252.

   Not in our library10.1016/s0896-6273(00)80886-7

2. 2.

   Ahlskog JE. Challenging conventional wisdom: the etiologic role of dopamine oxidative stress in Parkinson's disease. Mov. Disord. 2005;20:271-282.

   Not in our library10.1002/mds.20362

3. 3.

   Albanese A, Valente EM, Romito LM, Bellacchio E, Elia AE, Dallapiccola B. The PINK1 phenotype can be indistinguishable from idiopathic Parkinson disease. Neurology. 2005;64:1958-1960.

   Not in our library10.1212/01.wnl.0000163999.72864.fd

4. 4.

   Albani D, Polito L, Batelli S, De Mauro S, Fracasso C, Martelli G, Colombo L, Manzoni C, Salmona M, Caccia S, Negro A, Forloni G. The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide. J. Neurochem. 2009;110:1445-1456.

   Not in our library10.1111/j.1471-4159.2009.06228.x

5. 5.

   Allen NJ, Barres BA. Neuroscience: Glia – more than just brain glue. Nature. 2009;457:675-677.

   Not in our library10.1038/457675a

6. 6.

   Alonso J, Castellano MA, Rodriguez M. Behavioral lateralization in rats: prenatal stress effects on sex differences. Brain Res. 1991a;539:45-50.

   Not in our library10.1016/0006-8993(91)90684-n

7. 7.

   Alonso SJ, Castellano MA, Afonso D, Rodriguez M. Sex differences in behavioral despair: relationships between behavioral despair and open field activity. Physiol. Behav. 1991b;49:69-72.

   Not in our library10.1016/0031-9384(91)90232-d

8. 8.

   Alvira D, Yeste-Velasco M, Folch J, Verdaguer E, Canudas AM, Pallas M, Camins A. Comparative analysis of the effects of resveratrol in two apoptotic models: inhibition of complex I and potassium deprivation in cerebellar neurons. Neuroscience. 2007;147:746-756.

   Not in our library10.1016/j.neuroscience.2007.04.029

9. 9.
   Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins · 2011

   No notice
10. 10.

    Amiri M, Hollenbeck PJ. Mitochondrial biogenesis in the axons of vertebrate peripheral neurons. Dev. Neurobiol. 2008;68:1348-1361.

    Not in our library10.1002/dneu.20668

11. 11.

    Arango V, Underwood MD, Pauler DK, Kass RE, Mann JJ. Differential age-related loss of pigmented locus coeruleus neurons in suicides, alcoholics, and alcoholic suicides. Alcohol. Clin. Exp. Res. 1996;20:1141-1147.

    Not in our library10.1111/j.1530-0277.1996.tb01102.x

12. 12.

    Arevalo R, Afonso D, Castro R, Rodriguez M. Fetal brain serotonin synthesis and catabolism is under control by mother intake of tryptophan. Life Sci. 1991;49:53-66.

    Not in our library10.1016/0024-3205(91)90579-z

13. 13.

    Asanuma M, Hirata H, Cadet JL. Attenuation of 6-hydroxydopamine-induced dopaminergic nigrostriatal lesions in superoxide dismutase transgenic mice. Neuroscience. 1998;85:907-917.

    Not in our library10.1016/s0306-4522(97)00665-9

14. 14.

    Atzmon G, Schechter C, Greiner W, Davidson D, Rennert G, Barzilai N. Clinical phenotype of families with longevity. J. Am. Geriatr. Soc. 2004;52:274-277.

    Not in our library10.1111/j.1532-5415.2004.52068.x

15. 15.

    Austad SN. Is aging programed? Aging Cell. 2004;3:249-251.

    Not in our library10.1111/j.1474-9728.2004.00112.x

16. 16.

    Ayyadevara S, Alla R, Thaden JJ, Shmookler Reis RJ. Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell. 2008;7:13-22.

    Not in our library10.1111/j.1474-9726.2007.00348.x

17. 17.

    Bai XY, Ma Y, Ding R, Fu B, Shi S, Chen XM. miR-335 and miR-34a Promote renal senescence by suppressing mitochondrial antioxidative enzymes. J. Am. Soc. Nephrol. 2011;22:1252-1261.

    Not in our library10.1681/asn.2010040367

18. 18.

    Baker KG, Tork I, Hornung JP, Halasz P. The human locus coeruleus complex: an immunohistochemical and three dimensional reconstruction study. Exp. Brain Res. 1989;77:257-270.

    Not in our library10.1007/bf00274983

19. 19.

    Ballard PA, Tetrud JW, Langston JW. Permanent human parkinsonism due to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): seven cases. Neurology. 1985;35:949-956.

    Not in our library10.1212/wnl.35.7.949

20. 20.
    Nuclear Outsourcing of RNA Interference Components to Human Mitochondria · 2011

    No notice
21. 21.

    Barcia C, Sanchez Bahillo A, Fernandez-Villalba E, Bautista V, Poza YPM, Fernandez-Barreiro A, Hirsch EC, Herrero MT. Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure. Glia. 2004;46:402-409.

    Not in our library10.1002/glia.20015

22. 22.

    Barja G. Endogenous oxidative stress: relationship to aging, longevity and caloric restriction. Ageing Res. Rev. 2002a;1:397-411.

    Not in our library10.1016/s1568-1637(02)00008-9

23. 23.

    Barja G. Rate of generation of oxidative stress-related damage and animal longevity. Free Radic. Biol. Med. 2002b;33:1167-1172.

    Not in our library10.1016/s0891-5849(02)00910-3

24. 24.

    Barja G, Herrero A. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. Faseb J. 2000;14:312-318.

    Not in our library10.1096/fasebj.14.2.312

25. 25.

    Barrio JR, Huang SC, Melega WP, Yu DC, Hoffman JM, Schneider JS, Satyamurthy N, Mazziotta JC, Phelps ME. 6-[18F]fluoro-L-dopa probes dopamine turnover rates in central dopaminergic structures. J. Neurosci. Res. 1990;27:487-493.

    Not in our library10.1002/jnr.490270408

26. 26.

    Beal MF. Mitochondrial dysfunction in neurodegenerative diseases. Biochim. Biophys. Acta. 1998;1366:211-223.

    Not in our library10.1016/s0005-2728(98)00114-5

27. 27.

    Belanger M, Allaman I, Magistretti PJ. Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab. 2011;14:724-738.

    Not in our library10.1016/j.cmet.2011.08.016

28. 28.
    Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain · 2011

    No notice
29. 29.

    Benarroch EE. Astrocyte-neuron interactions: implications for epilepsy. Neurology. 2009;73:1323-1327.

    Not in our library10.1212/wnl.0b013e3181bd432d

30. 30.

    Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T, Taylor RW, Turnbull DM. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat. Genet. 2006;38:515-517.

    Not in our library10.1038/ng1769

31. 31.

    Berg D, Hochstrasser H. Iron metabolism in Parkinsonian syndromes. Mov. Disord. 2006;21:1299-1310.

    Not in our library10.1002/mds.21020

32. 32.

    Bertrand E, Lechowicz W, Szpak GM, Dymecki J. Qualitative and quantitative analysis of locus coeruleus neurons in Parkinson's disease. Folia Neuropathol. 1997;35:80-86.

    Not in our library

33. 33.

    Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 2000;3:1301-1306.

    Not in our library10.1038/81834

34. 34.

    Bokov A, Chaudhuri A, Richardson A. The role of oxidative damage and stress in aging. Mech. Ageing Dev. 2004;125:811-826.

    Not in our library10.1016/j.mad.2004.07.009

35. 35.

    Bonifati V, Rizzu P, Squitieri F, Krieger E, Vanacore N, van Swieten JC, Brice A, van Duijn CM, Oostra B, Meco G, Heutink P. DJ-1(PARK7), a novel gene for autosomal recessive, early onset parkinsonism. Neurol. Sci. 2003a;24:159-160.

    Not in our library10.1007/s10072-003-0108-0

36. 36.

    Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, Heutink P. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science. 2003b;299:256-259.

    Not in our library10.1126/science.1077209

37. 37.

    Bonilla E, Tanji K, Hirano M, Vu TH, DiMauro S, Schon EA. Mitochondrial involvement in Alzheimer's disease. Biochim. Biophys. Acta. 1999;1410:171-182.

    Not in our library10.1016/s0005-2728(98)00165-0

38. 38.

    Boore JL. Animal mitochondrial genomes. Nucleic Acids Res. 1999;27:1767-1780.

    Not in our library10.1093/nar/27.8.1767

39. 39.

    Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P, Lerner RA, Kelly JW. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization. Nat. Chem. Biol. 2006;2:249-253.

    Not in our library10.1038/nchembio782

40. 40.

    Bossy-Wetzel E, Schwarzenbacher R, Lipton SA. Molecular pathways to neurodegeneration. Nat. Med. 2004;10(Suppl):S2-S9.

    Not in our library10.1038/nm1067

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