Skip to content
naulon

No retraction, correction or concern found when last checked on Oct 19, 2026.

Polarisation optics for biomedical and clinical applications: a review

Chao He, Honghui He, Jintao Chang and 3 more

Light: Science & Applications · 2021 · Review · CC BY

doi:10.1038/s41377-021-00639-x

Abstract

Many polarisation techniques have been harnessed for decades in biological and clinical research, each based upon measurement of the vectorial properties of light or the vectorial transformations imposed on light by objects. Various advanced vector measurement/sensing techniques, physical interpretation methods, and approaches to analyse biomedically relevant information have been developed and harnessed. In this review, we focus mainly on summarising methodologies and applications related to tissue polarimetry, with an emphasis on the adoption of the Stokes–Mueller formalism. Several recent breakthroughs, development trends, and potential multimodal uses in conjunction with other techniques are also presented. The primary goal of the review is to give the reader a general overview in the use of vectorial information that can be obtained by polarisation optics for applications in biomedical and clinical research.

Full text

Its licence does not allow us to show the full text. Read it at PubMed Central:

Read at PubMed Central

References 289

  1. 1.

    Ronchi, V. & Barocas, V. The Nature of Light: An Historical Survey (Harvard University Press, 1970).

    Not in our library

  2. 2.

    Huard, S. Polarization of Light (Wiley, 1997).

    Not in our library

  3. 3.

    Goldstein, D. Polarized Light 2nd edn (Marcel Dekker, 2003).

    Not in our library

  4. 4.

    Chipman, R. A., Lam, W. S. T. & Young, G. Polarized Light and Optical Systems (CRC Press, 2018).

    Not in our library

  5. 5.

    Pérez, J. J. G. & Ossikovski, R. Polarized Light and the Mueller Matrix Approach (CRC Press, 2017).

    Not in our library

  6. 6.

    Zhan QW. Cylindrical vector beams: from mathematical concepts to applications. Adv. Opt. Photonics. 2009;1:1-57.

    Not in our library10.1364/aop.1.000001

  7. 7.

    Rosales-Guzmán C, Ndagano B, Forbes A. A review of complex vector light fields and their applications. J. Opt. 2018;20:123001.

    Not in our library10.1088/2040-8986/aaeb7d

  8. 8.

    Forbes A, De Oliveira M, Dennis MR. Structured light. Nat. Photonics. 2021;15:253-262.

    Not in our library10.1038/s41566-021-00780-4

  9. 9.

    Wang JW, Castellucci F, Franke-Arnold S. Vectorial light–matter interaction: exploring spatially structured complex light fields. AVS Quantum Sci. 2020;2:031702.

    Not in our library10.1116/5.0016007

  10. 10.

    Slussarenko S, et al. Guiding light via geometric phases. Nat. Photonics. 2016;10:571-575.

    Not in our library10.1038/nphoton.2016.138

  11. 11.

    Cloude, S. Polarisation: Applications in Remote Sensing (OUP Oxford, 2009).

    Not in our library

  12. 12.

    Ndagano B, et al. Characterizing quantum channels with non-separable states of classical light. Nat. Phys. 2017;13:397-402.

    Not in our library10.1038/nphys4003

  13. 13.

    Marrucci L, Manzo C, Paparo D. Optical spin-to-orbital angular momentum conversion in inhomogeneous anisotropic media. Phys. Rev. Lett. 2006;96:163905.

    Not in our library10.1103/physrevlett.96.163905

  14. 14.

    Bliokh KY, et al. Spin-orbit interactions of light. Nat. Photonics. 2015;9:796-808.

    Not in our library10.1038/nphoton.2015.201

  15. 15.
  16. 16.

    He HH, et al. Mueller matrix polarimetry—an emerging new tool for characterizing the microstructural feature of complex biological specimen. J. Lightwave Technol. 2019;37:2534-2548.

    Not in our library10.1109/jlt.2018.2868845

  17. 17.

    Oldenbourg R. A new view on polarization microscopy. Nature. 1996;381:811-812.

    Not in our library10.1038/381811a0

  18. 18.

    Gurjar RS, et al. Imaging human epithelial properties with polarized light-scattering spectroscopy. Nat. Med. 2001;7:1245-1248.

    Not in our library10.1038/nm1101-1245

  19. 19.

    Qiu L, et al. Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett’s esophagus. Nat. Med. 2010;16:603-606.

    Not in our library10.1038/nm.2138

  20. 20.

    Ghosh N, Vitkin IA. Tissue polarimetry: concepts, challenges, applications, and outlook. J. Biomed. Opt. 2011;16:110801.

    Not in our library10.1117/1.3652896

  21. 21.

    Novikova T, et al. Special section guest editorial: polarized light for biomedical applications. J. Biomed. Opt. 2016;21:071001.

    Not in our library10.1117/1.jbo.21.7.071001

  22. 22.

    Tuchin VV. Polarized light interaction with tissues. J. Biomed. Opt. 2016;21:071114.

    Not in our library10.1117/1.jbo.21.7.071114

  23. 23.

    Ramella-Roman JC, Saytashev I, Piccini M. A review of polarization-based imaging technologies for clinical and preclinical applications. J. Opt. 2020;22:123001.

    Not in our library10.1088/2040-8986/abbf8a

  24. 24.

    Qi J, Elson DS. Mueller polarimetric imaging for surgical and diagnostic applications: a review. J. Biophotonics. 2017;10:950-982.

    Not in our library10.1002/jbio.201600152

  25. 25.

    Fujiwara, H. Spectroscopic Ellipsometry: Principles and Applications (John Wiley & Sons, 2007).

    Not in our library

  26. 26.

    Azzam RMA, Bashara NM, Ballard SS. Ellipsometry and polarized light. Phys. Today. 1978;31:72.

    Not in our library10.1063/1.2994821

  27. 27.

    Mendoza-Galván A, et al. Mueller matrix spectroscopic ellipsometry study of chiral nanocrystalline cellulose films. J. Opt. 2018;20:024001.

    Not in our library10.1088/2040-8986/aa9e7d

  28. 28.

    Azzam RMA. Stokes-vector and Mueller-matrix polarimetry. J. Optical Soc. Am. A. 2016;33:1396-1408.

    Not in our library10.1364/josaa.33.001396

  29. 29.

    Azzam RMA. Mueller-matrix ellipsometry: a review. Proc. SPIE. 1997;3121:369-405.

    Not in our library

  30. 30.

    Song BK, et al. Broadband optical properties of graphene and HOPG investigated by spectroscopic Mueller matrix ellipsometry. Appl. Surf. Sci. 2018;439:1079-1087.

    Not in our library10.1016/j.apsusc.2018.01.051

  31. 31.

    Jiang H, et al. Characterization of volume gratings based on distributed dielectric constant model using Mueller matrix ellipsometry. Appl. Sci. 2019;9:698.

    Not in our library10.3390/app9040698

  32. 32.

    Chang JT, et al. Division of focal plane polarimeter-based 3×4 Mueller matrix microscope: a potential tool for quick diagnosis of human carcinoma tissues. J. Biomed. Opt. 2016;21:056002.

    Not in our library10.1117/1.jbo.21.5.056002

  33. 33.

    Fu YF, et al. Flexible 3×3 Mueller matrix endoscope prototype for cancer detection. IEEE Trans. Instrum. Meas. 2018;67:1700-1712.

    Not in our library10.1109/tim.2018.2803847

  34. 34.

    De Boer JF, Hitzenberger CK, Yasuno Y. Polarization sensitive optical coherence tomography—a review. Biomed. Opt. Express. 2017;8:1838-1873.

    Not in our library10.1364/boe.8.001838

  35. 35.

    Ghosh N, Patel HS, Gupta PK. Depolarization of light in tissue phantoms—effect of a distribution in the size of scatterers. Opt. Express. 2003;11:2198-2205.

    Not in our library10.1364/oe.11.002198

  36. 36.

    Kienle A, Hibst R. Light guiding in biological tissue due to scattering. Phys. Rev. Lett. 2006;97:018104.

    Not in our library10.1103/physrevlett.97.018104

  37. 37.

    Baravian C, Dillet J, Decruppe JP. Birefringence determination in turbid media. Phys. Rev. E. 2007;75:032501.

    Not in our library10.1103/physreve.75.032501

  38. 38.

    Wang XD, Wang LV. Propagation of polarized light in birefringent turbid media: a Monte Carlo study. J. Biomed. Opt. 2002;7:279-290.

    Not in our library10.1117/1.1483315

  39. 39.

    Wang XD, Wang LV. Propagation of polarized light in birefringent turbid media: time-resolved simulations. Opt. Express. 2001;9:254-259.

    Not in our library10.1364/oe.9.000254

  40. 40.

    Du E, et al. Two-dimensional backscattering Mueller matrix of sphere-cylinder birefringence media. J. Biomed. Opt. 2012;17:126016.

    Not in our library10.1117/1.jbo.17.12.126016

All 289 references

Cited by papers we hold 1

Reads

Read by people on this page

None yet.

Checked or read by AI through naulon

None yet.

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.

Are you an author?

Is this your paper?

Claim it to add your note and be paid when agents cite it. Free.