Redox biology of hydrogen sulfide: Implications for physiology, pathophysiology, and pharmacology

Abstract

Hydrogen sulfide (H2S) has emerged as a critical mediator of multiple physiological processes in mammalian systems. The pathways involved in the production, consumption, and mechanism of action of H2S appear to be sensitive to alterations in the cellular redox state and O2 tension. Indeed, the catabolism of H2S through a putative oxidation pathway, the sulfide quinone oxido-reductase system, is highly dependent on O2 tension. Dysregulation of H2S homeostasis has also been implicated in numerous pathological conditions and diseases. In this review, the chemistry and the main physiological actions of H2S are presented. Some examples highlighting the cytoprotective actions of H2S within the context of cardiovascular disease are also reported. Elucidation of the redox biology of H2S will enable the development of new pharmacological agents based on this intriguing new redox cellular signal.

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Cited by papers we hold 4

• Homocysteine and Mitochondria in Cardiovascular and Cerebrovascular Systems · 2020
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• The Effects of Nutrition on the Gastrointestinal Microbiome of Cats and Dogs: Impact on Health and Disease · 2020
  No notice
• Role of Hydrogen Sulfide in Ischemia-Reperfusion Injury · 2015
  No notice
• Launch of Redox Biology: A new venue for studies in translational, basic and applied research in the fields of antioxidants, cell signaling and redox therapeutics · 2013
  Not checked

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