Concise Review: Bone Marrow-Derived Stem/Progenitor Cells in Cutaneous Repair and Regeneration

Abstract

Our understanding of the role of bone marrow (BM)-derived cells in cutaneous homeostasis and wound healing had long been limited to the contribution of inflammatory cells. Recent studies, however, suggest that the BM contributes a significant proportion of noninflammatory cells to the skin, which are present primarily in the dermis in fibroblast-like morphology and in the epidermis in a keratinocyte phenotype; and the number of these BM-derived cells increases markedly after wounding. More recently, several studies indicate that mesenchymal stem cells derived from the BM could significantly impact wound healing in diabetic and nondiabetic animals, through cell differentiation and the release of paracrine factors, implying a profound therapeutic potential. This review discusses the most recent understanding of the contribution of BM-derived noninflammatory cells to cutaneous homeostasis and wound healing.

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Cited by papers we hold 5

• Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines · 2021
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• Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression · 2015
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• Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors · 2013
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• Amniotic Mesenchymal Stem Cells Enhance Wound Healing in Diabetic NOD/SCID Mice through High Angiogenic and Engraftment Capabilities · 2012
  Corrected
• Epigenetic Dysregulation in Mesenchymal Stem Cell Aging and Spontaneous Differentiation · 2011
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