Concise Review: Bone Marrow-Derived Stem/Progenitor Cells in Cutaneous Repair and Regeneration

Abstract

Our understanding of the role of bone marrow (BM)-derived cells in cutaneous homeostasis and wound healing had long been limited to the contribution of inflammatory cells. Recent studies, however, suggest that the BM contributes a significant proportion of noninflammatory cells to the skin, which are present primarily in the dermis in fibroblast-like morphology and in the epidermis in a keratinocyte phenotype; and the number of these BM-derived cells increases markedly after wounding. More recently, several studies indicate that mesenchymal stem cells derived from the BM could significantly impact wound healing in diabetic and nondiabetic animals, through cell differentiation and the release of paracrine factors, implying a profound therapeutic potential. This review discusses the most recent understanding of the contribution of BM-derived noninflammatory cells to cutaneous homeostasis and wound healing.

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109. 109.

     Rehman J, Li J, Orschell CM, et al. Peripheral blood “endothelial progenitor cells” are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation. 2003;107:1164-1169.

     Not in our library10.1161/01.cir.0000058702.69484.a0

110. 110.

     Edelberg JM, Tang L, Hattori K, et al. Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ Res. 2002;90:E89-E93.

     Not in our library10.1161/01.res.0000020861.20064.7e

111. 111.

     Barcelos LS, Duplaa C, Krankel N, et al. Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling. Circ Res. 2009;104:1095-1102.

     Not in our library10.1161/circresaha.108.192138

112. 112.

     Loomans CJ, de Koning EJ, Staal FJ, et al. Endothelial progenitor cell dysfunction: A novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes. 2004;53:195-199.

     Not in our library10.2337/diabetes.53.1.195

113. 113.

     Tepper OM, Galiano RD, Capla JM, et al. Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures. Circulation. 2002;106:2781-2786.

     Not in our library10.1161/01.cir.0000039526.42991.93

114. 114.

     Stepanovic V, Awad O, Jiao C, et al. Leprdb diabetic mouse bone marrow cells inhibit skin wound vascularization but promote wound healing. Circ Res. 2003;92:1247-1253.

     Not in our library10.1161/01.res.0000074906.98021.55

115. 115.

     Gallagher KA, Liu ZJ, Xiao M, et al. Diabetic impairments in NO-mediated endothelial progenitor cell mobilization and homing are reversed by hyperoxia and SDF-1 alpha. J Clin Invest. 2007;117:1249-1259.

     Not in our library10.1172/jci29710

116. 116.

     Chesney J, Bacher M, Bender A, et al. The peripheral blood fibrocyte is a potent antigen-presenting cell capable of priming naive T cells in situ. Proc Natl Acad Sci USA. 1997;94:6307-6312.

     Not in our library10.1073/pnas.94.12.6307

117. 117.

     Quan TE, Cowper S, Wu SP, et al. Circulating fibrocytes: Collagen-secreting cells of the peripheral blood. Int J Biochem Cell Biol. 2004;36:598-606.

     Not in our library10.1016/j.biocel.2003.10.005

118. 118.

     Bucala R, Spiegel LA, Chesney J, et al. Circulating fibrocytes define a new leukocyte subpopulation that mediates tissue repair. Mol Med. 1994;1:71-81.

     Not in our library

119. 119.

     Okada H, Kalluri R. Cellular and molecular pathways that lead to progression and regression of renal fibrogenesis. Curr Mol Med. 2005;5:467-474.

     Not in our library10.2174/1566524054553478

120. 120.

     Mori L, Bellini A, Stacey MA, et al. Fibrocytes contribute to the myofibroblast population in wounded skin and originate from the bone marrow. Exp Cell Res. 2005;304:81-90.

     Not in our library10.1016/j.yexcr.2004.11.011

121. 121.

     Yang L, Scott PG, Dodd C, et al. Identification of fibrocytes in postburn hypertrophic scar. Wound Repair Regen. 2005;13:398-404.

     Not in our library10.1111/j.1067-1927.2005.130407.x

122. 122.

     Wang J, Dodd C, Shankowsky HA, et al. Deep dermal fibroblasts contribute to hypertrophic scarring. Lab Invest. 2008;88:1278-1290.

     Not in our library10.1038/labinvest.2008.101

123. 123.

     Abe R, Donnelly SC, Peng T, et al. Peripheral blood fibrocytes: Differentiation pathway and migration to wound sites. J Immunol. 2001;166:7556-7562.

     Not in our library10.4049/jimmunol.166.12.7556

124. 124.

     Ortiz LA, Gambelli F, McBride C, et al. Mesenchymal stem cell engraftment in lung is enhanced in response to bleomycin exposure and ameliorates its fibrotic effects. Proc Natl Acad Sci USA. 2003;100:8407-8411.

     Not in our library10.1073/pnas.1432929100

Cited by papers we hold 5

• Mesenchymal stem cells as a double-edged sword in tumor growth: focusing on MSC-derived cytokines · 2021
  No notice
• Mesenchymal Stem Cell-Mediated Effects of Tumor Support or Suppression · 2015
  No notice
• Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors · 2013
  No notice
• Amniotic Mesenchymal Stem Cells Enhance Wound Healing in Diabetic NOD/SCID Mice through High Angiogenic and Engraftment Capabilities · 2012
  Corrected
• Epigenetic Dysregulation in Mesenchymal Stem Cell Aging and Spontaneous Differentiation · 2011
  No notice

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