Monocyte heterogeneity and functions in cancer

Abstract

Monocytes are innate immune cells of the mononuclear phagocyte system that have emerged as important regulators of cancer development and progression. Our understanding of monocytes has advanced from viewing these cells as a homogenous population to a heterogeneous system of cells that display diverse responses to different stimuli. During cancer, different monocyte subsets perform functions that contribute to both pro- and antitumoral immunity, including phagocytosis, secretion of tumoricidal mediators, promotion of angiogenesis, remodeling of the extracellular matrix, recruitment of lymphocytes, and differentiation into tumor-associated macrophages and dendritic cells. The ability of cancer to evade immune recognition and clearance requires protumoral signals to outweigh ongoing attempts by the host immune system to prevent tumor growth. This review discusses current understanding of monocyte heterogeneity during homeostasis, highlights monocyte functions in cancer progression, and describes monocyte-targeted therapeutic strategies for cancer treatment.

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References 146

1. 1.

   Shi C, Pamer EG. Monocyte recruitment during infection and inflammation. Nat Rev Immunol. 2011;11:762–774.

   Not in our library10.1038/nri3070

2. 2.

   Qian B‐Z, Li J, Zhang H, et al. CCL2 recruits inflammatory monocytes to facilitate breast‐tumour metastasis. Nature. 2011;475:222–225.

   Not in our library10.1038/nature10138

3. 3.

   Hanna RN, Cekic C, Sag D, et al. Patrolling monocytes control tumor metastasis to the lung. Science. 2015;350:985–990.

   Not in our library10.1126/science.aac9407

4. 4.

   Engblom C, Pfirschke C, Pittet MJ. The role of myeloid cells in cancer therapies. Nat Rev Cancer. 2016;16:447–462.

   Not in our library10.1038/nrc.2016.54

5. 5.

   Ziegler‐Heitbrock L, Ancuta P, Crowe S, et al. Nomenclature of monocytes and dendritic cells in blood. Blood. 2010;116:e74–e80.

   Not in our library10.1182/blood-2010-02-258558

6. 6.

   Passlick B, Flieger D, Ziegler‐Heitbrock HW. Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood. 1989;74:2527–2534.

   Not in our library

7. 7.

   Palframan RT, Jung S, Cheng G, et al. Inflammatory chemokine transport and presentation in hev: A remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J Exp Med. 2001;194:1361–1374.

   Not in our library10.1084/jem.194.9.1361

8. 8.

   Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003;19:71–82.

   Not in our library10.1016/s1074-7613(03)00174-2

9. 9.

   Sunderkötter C, Nikolic T, Dillon MJ, et al. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol. 2004;172:4410–4417.

   Not in our library10.4049/jimmunol.172.7.4410

10. 10.

    Ingersoll MA, Spanbroek R, Lottaz C, et al. Comparison of gene expression profiles between human and mouse monocyte subsets. Blood. 2010;115:e10–e19.

    Not in our library10.1182/blood-2009-07-235028

11. 11.

    Mildner A, Schönheit J, Giladi A, et al. Genomic characterization of murine monocytes reveals C/EBPβ transcription factor dependence of Ly6C− cells. Immunity. 2017;46:849–862.

    Not in our library10.1016/j.immuni.2017.04.018

12. 12.

    Cros J, Cagnard N, Woollard K, et al. Human CD14dim monocytes patrol and sense nucleic acids and viruses via TLR7 and TLR8 receptors. Immunity. 2010;33:375–386.

    Not in our library10.1016/j.immuni.2010.08.012

13. 13.

    Thomas GD, Hamers AAJ, Nakao C, et al. Human blood monocyte subsets: a new gating strategy defined using cell surface markers identified by mass cytometry. Arterioscler Thromb Vasc Biol. 2017;37:1548–1558.

    Not in our library10.1161/atvbaha.117.309145

14. 14.

    Jakubzick CV, Randolph GJ, Henson PM. Monocyte differentiation and antigen‐presenting functions. Nat Rev Immunol. 2017;2018:349–362.

    Not in our library10.1038/nri.2017.28

15. 15.

    Briseño CG, Haldar M, Kretzer NM, et al. Distinct transcriptional programs control cross‐priming in classical and monocyte‐derived dendritic cells. Cell Rep. 2016;15:2462–2474.

    Not in our library10.1016/j.celrep.2016.05.025

16. 16.

    Villani A‐C, Satija R, Reynolds G, et al. Single‐cell RNA‐seq reveals new types of human blood dendritic cells, monocytes, and progenitors. Science. 2017;356:eaah4573.

    Not in our library10.1126/science.aah4573

17. 17.
    The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells · 2016

    No notice
18. 18.

    Hettinger J, Richards DM, Hansson J, et al. Origin of monocytes and macrophages in a committed progenitor. Nat Immunol. 2013;14:821–830.

    Not in our library10.1038/ni.2638

19. 19.

    Kawamura S, Onai N, Miya F, et al. Identification of a human clonogenic progenitor with strict monocyte differentiation potential: a counterpart of mouse cMoPs. Immunity. 2017;46:835–848.

    Not in our library10.1016/j.immuni.2017.04.019

20. 20.

    Zhu YP, Thomas GD, Hedrick CC. 2014 Jeffrey M. Hoeg award lecture: transcriptional control of monocyte development. Arterioscler Thromb Vasc Biol. 2016;36:1722–1733.

    Not in our library10.1161/atvbaha.116.304054

21. 21.

    Scott EW, Simon MC, Anastasi J, Singh H. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science. 1994;265:1573–1577.

    Not in our library10.1126/science.8079170

22. 22.

    Kurotaki D, Yamamoto M, Nishiyama A, et al. IRF8 inhibits C/EBPα activity to restrain mononuclear phagocyte progenitors from differentiating into neutrophils. Nat Commun. 2014;5:4978.

    Not in our library10.1038/ncomms5978

23. 23.

    Kurotaki D, Osato N, Nishiyama A, et al. Essential role of the IRF8‐KLF4 transcription factor cascade in murine monocyte differentiation. Blood. 2013;121:1839–1849.

    Not in our library10.1182/blood-2012-06-437863

24. 24.

    Lee J, Breton G, Oliveira TYK, et al. Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow. J Exp Med. 2015;212:385–399.

    Not in our library10.1084/jem.20141442

25. 25.

    Yáñez A, Coetzee SG, Olsson A, et al. Granulocyte‐Monocyte progenitors and monocyte‐dendritic cell progenitors independently produce functionally distinct monocytes. Immunity. 2017;47:890–902.

    Not in our library10.1016/j.immuni.2017.10.021

26. 26.

    Yona S, Kim K‐W, Wolf Y, et al. Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity. 2013;38:79–91.

    Not in our library10.1016/j.immuni.2012.12.001

27. 27.

    Varol C, Landsman L, Fogg DK, et al. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med. 2007;204:171–180.

    Not in our library10.1084/jem.20061011

28. 28.
    The fate and lifespan of human monocyte subsets in steady state and systemic inflammation · 2017

    No notice
29. 29.

    Hanna RN, Carlin LM, Hubbeling HG, et al. The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes. Nat Immunol. 2011;12:778–785.

    Not in our library10.1038/ni.2063

30. 30.

    Thomas GD, Hanna RN, Vasudevan NT, et al. Deleting an Nr4a1 super‐enhancer subdomain ablates Ly6Clow monocytes while preserving macrophage gene function. Immunity. 2016;45:975–987.

    Not in our library10.1016/j.immuni.2016.10.011

31. 31.

    Tamura A, Hirai H, Yokota A, et al. C/EBPβ is required for survival of Ly6C− monocytes. Blood. 2017;130:1809–1818.

    Not in our library10.1182/blood-2017-03-772962

32. 32.
    Regulation of monocyte cell fate by blood vessels mediated by Notch signalling · 2016

    Corrected
33. 33.

    Satoh T, Nakagawa K, Sugihara F, et al. Identification of an atypical monocyte and committed progenitor involved in fibrosis. Nature. 2017;541:96–101.

    Not in our library10.1038/nature20611

34. 34.

    Serbina NV, Pamer EG. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat Immunol. 2006;7:311–317.

    Not in our library10.1038/ni1309

35. 35.

    Jakubzick C, Gautier EL, Gibbings SL, et al. Minimal differentiation of classical monocytes as they survey steady‐state tissues and transport antigen to lymph nodes. Immunity. 2013;39:599–610.

    Not in our library10.1016/j.immuni.2013.08.007

36. 36.

    Auffray C, Fogg D, Garfa M, et al. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science. 2007;317:666–670.

    Not in our library10.1126/science.1142883

37. 37.

    Debien E, Mayol K, Biajoux V, et al. S1PR5 is pivotal for the homeostasis of patrolling monocytes. Eur J Immunol. 2013;43:1667–1675.

    Not in our library10.1002/eji.201343312

38. 38.

    Lavin Y, Kobayashi S, Leader A, et al. Innate immune landscape in early lung adenocarcinoma by paired single‐cell analyses. Cell. 2017;169:750–765.

    Not in our library10.1016/j.cell.2017.04.014

39. 39.

    Azizi E, Carr AJ, Plitas G, et al. Single‐Cell map of diverse immune phenotypes in the breast tumor microenvironment. Cell. 2018;174:1293–1308.

    Not in our library10.1016/j.cell.2018.05.060

40. 40.

    Jakubzick C, Tacke F, Ginhoux F, et al. Blood monocyte subsets differentially give rise to CD103+ and CD103− pulmonary dendritic cell populations. J Immunol. 2008;180:3019–3027.

    Not in our library10.4049/jimmunol.180.5.3019

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