Advances in the Sensing and Treatment of Wound Biofilms

Abstract

Wound biofilms represent a particularly challenging problem in modern medicine. They are increasingly antibiotic resistant and can prevent the healing of chronic wounds. However, current treatment and diagnostic options are hampered by the complexity of the biofilm environment. In this review, we present new chemical avenues in biofilm sensors and new materials to treat wound biofilms, offering promise for better detection, chemical specificity, and biocompatibility. We briefly discuss existing methods for biofilm detection and focus on novel, sensor‐based approaches that show promise for early, accurate detection of biofilm formation on wound sites and that can be translated to point‐of‐care settings. We then discuss technologies inspired by new materials for efficient biofilm eradication. We focus on ultrasound‐induced microbubbles and nanomaterials that can both penetrate the biofilm and simultaneously carry active antimicrobials and discuss the benefits of those approaches in comparison to conventional methods.

References 340

1. 1.

   U. Römling, S. Kjelleberg, S. Normark, L. Nyman, B. E. Uhlin, B. Åkerlund, J. Intern. Med. 2014, 276, 98–110.

   Not in our library10.1111/joim.12242

2. 2.

   R. Wolcott, D. Rhoads, M. Bennett, B. Wolcott, L. Gogokhia, J. Costerton, S. Dowd, J. Wound Care 2010, 19, 45–53.

   Not in our library10.12968/jowc.2010.19.2.46966

3. 3.

   J. D. Bryers, Biotechnol. Bioeng. 2008, 100, 1–18.

   Not in our library10.1002/bit.21838

4. 4.
   Biofilms: Microbial Life on Surfaces · 2002

   No notice
5. 5.

   S. Fulaz, S. Vitale, L. Quinn, E. Casey, Trends Microbiol. 2019, 27, 915–926.

   Not in our library10.1016/j.tim.2019.07.004

6. 6.

   J. W. Costerton, P. S. Stewart, E. P. Greenberg, Science 1999, 284, 1318–1322.

   Not in our library10.1126/science.284.5418.1318

7. 7.

   This reference’s wording can’t be shown under the paper’s licence.

   Not in our library

8. 8.

   G. A. James, E. Swogger, R. Wolcott, E. d. Pulcini, P. Secor, J. Sestrich, J. W. Costerton, P. S. Stewart, Wound Repair Regen. 2008, 16, 37–44;

   Not in our library10.1111/j.1524-475x.2007.00321.x

9. 9.

   S. L. Percival, Wounds 2004, 16, 234–240;

   Not in our library

10. 10.

    S. G. Jones, R. Edwards, D. W. Thomas, Int. J. Low. Extrem. Wounds 2004, 3, 201–208.

    Not in our library10.1177/1534734604271810

11. 11.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

12. 12.

    A. Pormohammad, N. K. Monych, S. Ghosh, D. L. Turner, R. J. Turner, Antibiotics 2021, 10, 473;

    Not in our library10.3390/antibiotics10050473

13. 13.

    G. LuTheryn, P. Glynne-Jones, J. S. Webb, D. Carugo, Microb. Biotechnol. 2020, 13, 613–628;

    Not in our library10.1111/1751-7915.13471

14. 14.

    Y.-K. Wu, N.-C. Cheng, C.-M. Cheng, Trends Biotechnol. 2019, 37, 505–517;

    Not in our library10.1016/j.tibtech.2018.10.011

15. 15.

    J. Shepherd, Emerging Top. Life Sci. 2020, 4, 567–580.

    Not in our library10.1042/etls20200155

16. 16.
    Biofilm delays wound healing: A review of the evidence · 2013

    No notice
17. 17.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

18. 18.

    S. L. Percival, S. M. McCarty, B. Lipsky, Adv. Wound Care 2015, 4, 373–381;

    Not in our library10.1089/wound.2014.0557

19. 19.

    L. Karygianni, Z. Ren, H. Koo, T. Thurnheer, Trends Microbiol. 2020, 28, 668–681.

    Not in our library10.1016/j.tim.2020.03.016

20. 20.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

21. 21.

    L. S. Miller, R. M. O'Connell, M. A. Gutierrez, E. M. Pietras, A. Shahangian, C. E. Gross, A. Thirumala, A. L. Cheung, G. Cheng, R. L. Modlin, Immunity 2006, 24, 79–91;

    Not in our library10.1016/j.immuni.2005.11.011

22. 22.

    L. Mölne, M. Verdrengh, A. Tarkowski, Infect. Immun. 2000, 68, 6162–6167.

    Not in our library10.1128/iai.68.11.6162-6167.2000

23. 23.

    T. Bjarnsholt, K. Kirketerp-Møller, P. Ø. Jensen, K. G. Madsen, R. Phipps, K. Krogfelt, N. Høiby, M. Givskov, Wound Repair Regen. 2008, 16, 2–10.

    Not in our library10.1111/j.1524-475x.2007.00283.x

24. 24.

    T. Bjarnsholt, P. Ø. Jensen, M. Burmølle, M. Hentzer, J. A. Haagensen, H. P. Hougen, H. Calum, K. G. Madsen, C. Moser, S. Molin, Microbiology 2005, 151, 373–383.

    Not in our library10.1099/mic.0.27463-0

25. 25.

    N. T. Thet, J. Mercer-Chalmers, R. J. Greenwood, A. E. Young, K. Coy, S. Booth, A. Sack, A. T. Jenkins, ACS Sens. 2020, 5, 2652–2657.

    Not in our library10.1021/acssensors.0c01265

26. 26.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

27. 27.
    Advanced Hydrogels as Wound Dressings · 2020

    No notice
28. 28.

    A. Banfi, W. Holnthoner, M. M. Martino, S. Ylä-Herttuala, Front. Bioeng. Biotechnol. 2018, 6, 175.

    Not in our library10.3389/fbioe.2018.00175

29. 29.

    A. Persat, C. D. Nadell, M. K. Kim, F. Ingremeau, A. Siryaporn, K. Drescher, N. S. Wingreen, B. L. Bassler, Z. Gitai, H. A. Stone, Cell 2015, 161, 988–997.

    Not in our library10.1016/j.cell.2015.05.005

30. 30.

    W. Li, X. Ying, Q. Lu, L. Chen, Genomics Proteomics Bioinf. 2012, 10, 276–284.

    Not in our library10.1016/j.gpb.2012.09.004

31. 31.

    H. Aiba, Curr. Opin. Microbiol. 2007, 10, 134–139.

    Not in our library10.1016/j.mib.2007.03.010

32. 32.

    H.-C. Flemming, J. Wingender, Nat. Rev. Microbiol. 2010, 8, 623–633.

    Not in our library10.1038/nrmicro2415

33. 33.

    P. Ø. Jensen, M. Kolpen, K. N. Kragh, M. Kühl, Apmis 2017, 125, 276–288.

    Not in our library10.1111/apm.12668

34. 34.

    H.-C. Flemming, J. Wingender, U. Szewzyk, P. Steinberg, S. A. Rice, S. Kjelleberg, Nat. Rev. Microbiol. 2016, 14, 563.

    Not in our library10.1038/nrmicro.2016.94

35. 35.

    K. Kirketerp-Møller, P. Ø. Jensen, M. Fazli, K. G. Madsen, J. Pedersen, C. Moser, T. Tolker-Nielsen, N. Høiby, M. Givskov, T. Bjarnsholt, J. Clin. Microbiol. 2008, 46, 2717–2722.

    Not in our library10.1128/jcm.00501-08

36. 36.

    A. Colsky, R. Kirsner, F. Kerdel, Ostomy Wound Manage. 1998, 44, 40.

    Not in our library

37. 37.

    This reference’s wording can’t be shown under the paper’s licence.

    Not in our library

38. 38.

    L. K. Rabe, D. Sheiness, S. L. Hillier, Clin. Infect. Dis. 1995, 20, S195–S197;

    Not in our library10.1093/clinids/20.supplement_2.s195

39. 39.

    J. L. Perry, J. Clin. Microbiol. 1997, 35, 1269–1271.

    Not in our library10.1128/jcm.35.5.1269-1271.1997

40. 40.

    S. M. Madsen, H. Westh, L. Danielsen, V. T. Rosdahl, Apmis 1996, 104, 895–899.

    Not in our library10.1111/j.1699-0463.1996.tb04955.x

Cited by papers we hold 1

• Current status and progress in research on dressing management for diabetic foot ulcer · 2023
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.