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100 papers95 with full text

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A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial
Nurulamin M Noor, James C Lee, Simon Bond et al. · The Lancet Gastroenterology & Hepatology · 2024 · Randomised trial
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Corrected
Updated safety results from phase 3 lecanemab study in early Alzheimer’s disease
Lawrence S. Honig, Marwan N. Sabbagh, Christopher H. van Dyck et al. · Alzheimer's Research & Therapy · 2024 · Randomised trial
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Corrected
Adjuvant nivolumab in resected stage IIB/C melanoma: primary results from the randomized, phase 3 CheckMate 76K trial
John M. Kirkwood, Michele Del Vecchio, Jeffrey Weber et al. · Nature Medicine · 2023 · Randomised trial
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Tirzepatide after intensive lifestyle intervention in adults with overweight or obesity: the SURMOUNT-3 phase 3 trial
Thomas A. Wadden, Ariana M. Chao, Sriram Machineni et al. · Nature Medicine · 2023 · Randomised trial
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Corrected
The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial
Lu Ma, Xin Hu, Lili Song et al. · The Lancet · 2023 · Randomised trial
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Corrected
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial
Catherine J. Mummery, Anne Börjesson-Hanson, Daniel J. Blackburn et al. · Nature Medicine · 2023 · Randomised trial
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Corrected
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial
R. Waziry, C. P. Ryan, D. L. Corcoran et al. · Nature Aging · 2023 · Randomised trial
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Corrected
MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial
Jennifer M. Mitchell, Marcela Ot’alora G., Bessel van der Kolk et al. · Nature Medicine · 2023 · Randomised trial
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Corrected
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial
Karim Fizazi, Arun A. Azad, Nobuaki Matsubara et al. · Nature Medicine · 2023 · Randomised trial
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Corrected
Avacincaptad pegol for geographic atrophy secondary to age-related macular degeneration: 18-month findings from the GATHER1 trial
Sunil S. Patel, David R. Lally, Jason Hsu et al. · Eye · 2023 · Randomised trial
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Corrected
Cabotegravir for the prevention of HIV-1 in women: results from HPTN 084, a phase 3, randomised clinical trial
Sinead Delany-Moretlwe, James P Hughes, Peter Bock et al. · The Lancet · 2022 · Randomised trial
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Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial
Solomon Tesfaye, Gordon Sloan, Jennifer Petrie et al. · The Lancet · 2022 · Randomised trial
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Corrected
The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial
Anthony Marson, Girvan Burnside, Richard Appleton et al. · The Lancet · 2021 · Randomised trial
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A phase 1 trial of lipid-encapsulated mRNA encoding a monoclonal antibody with neutralizing activity against Chikungunya virus
Allison August, Husain Z. Attarwala, Sunny Himansu et al. · Nature Medicine · 2021 · Randomised trial
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Corrected
A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Aβ protofibril antibody
Chad J. Swanson, Yong Zhang, Shobha Dhadda et al. · Alzheimer's Research & Therapy · 2021 · Randomised trial
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Corrected
Composite type-2 biomarker strategy versus a symptom–risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial
Liam G Heaney, John Busby, Catherine E Hanratty et al. · The Lancet Respiratory Medicine · 2021 · Randomised trial
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Home and Online Management and Evaluation of Blood Pressure (HOME BP) using a digital intervention in poorly controlled hypertension: randomised controlled trial
Richard J McManus, Paul Little, Beth Stuart et al. · BMJ · 2021 · Randomised trial
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Adjunctive host-directed therapies for pulmonary tuberculosis: a prospective, open-label, phase 2, randomised controlled trial
Robert S Wallis, Sibuse Ginindza, Trevor Beattie et al. · The Lancet Respiratory Medicine · 2021 · Randomised trial
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Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial
Evdoxia Kyriazopoulou, Garyfallia Poulakou, Haralampos Milionis et al. · Nature Medicine · 2021 · Randomised trial
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Long-term outcomes with frontline nilotinib versus imatinib in newly diagnosed chronic myeloid leukemia in chronic phase: ENESTnd 10-year analysis
Hagop M. Kantarjian, Timothy P. Hughes, Richard A. Larson et al. · Leukemia · 2021 · Randomised trial
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