Platelet Indices and Basic Coagulation Profile of Type 2 Diabetic Patients undergoing Haemodialysis in Rural Population

Introduction: Diabetes mellitus is rapidly growing and almost becoming epidemic, with currently 285 million people with diabetes worldwide. Chronic Kidney Disease (CKD) is evolving to be an important global disease, with diabetes playing a pivotal role behind this rapid outburst of CKD incidence. Aim: To evaluate platelet indices and to study the coagulation profile in haemodialysis patients having Type 2 diabetes with CKD and diabetic patients without CKD. Materials and Methods: This prospective study was conducted from March to December 2016 for 10 months. Two groups of patients were recruited. The first group (study group) consisted of 80 patients clinically diagnosed as CKD with Type 2 diabetes who were on haemodialysis treatment. The second group (controls) consisted of 80 cases diagnosed with Type 2 diabetes but without CKD, coming for routine checkups. Results: Male predominance was seen in both groups. The red blood cells and leukocyte counts were within the reference values and showed no statistical difference between the groups. Haemoglobin was slightly lowered in study group than controls. Although, platelet counts were similar between the groups, there was an increased in Mean Platelet Volume (MPV) in study group 9.84±2.28% and controls 6.59±1.69% with p-value 0.002 significant. Also, increased PDW in patient’s 17.93±2.79% and controls 15.15±1.39% with p-value 0.005 significant. Prothrombin Time (PT) and Activated Thromboplastin Time (APTT) both were increased in patients. Conclusion: Our study concluded that platelet indices play a crucial role in patients having diabetes with CKD. Basic coagulation profile aids in predicting the long term complications in such patients. Haemodialysis, in these patients have more advantageous effect with few preventable factors, which can be overcome with monitoring platelet indices and coagulation profile.

Abstract licence: CC BY-NC-ND

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