Multimodal sensory integration in single cerebellar granule cells in vivo

Abstract

The mammalian cerebellum is a highly multimodal structure, receiving inputs from multiple sensory modalities and integrating them during complex sensorimotor coordination tasks. Previously, using cell-type-specific anatomical projection mapping, it was shown that multimodal pathways converge onto individual cerebellar granule cells (Huang et al., 2013). Here we directly measure synaptic currents using in vivo patch-clamp recordings and confirm that a subset of single granule cells receive convergent functional multimodal (somatosensory, auditory, and visual) inputs via separate mossy fibers. Furthermore, we show that the integration of multimodal signals by granule cells can enhance action potential output. These recordings directly demonstrate functional convergence of multimodal signals onto single granule cells.

Cited by papers we hold 3

• Cerebellar Modules and Their Role as Operational Cerebellar Processing Units · 2018
  Corrected
• Recent advances in understanding the mechanisms of cerebellar granule cell development and function and their contribution to behavior [version 1; referees: 3 approved] · 2018
  Not checked
• Sparse synaptic connectivity is required for decorrelation and pattern separation in feedforward networks · 2017
  No notice

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