Application of the Domestic C-11 Multifunction Module in the Automated Synthesis of 11C-acetate

The domestic C-11 multifunction module was used to establish a simple, rapid, efficient synthetic technology for the fully automated synthesis of11C-acetate. Methyl magnesium bromide Grignard (0.1 mL of 1.5 mol/L) was used as a precursor to react with the 11C-CO2 in the Loop ring to produce intermediate acetyl bromide. The intermediate was first hydrolysis by acetic, and then purified, elution, and hydrochloric with acid. Then, the unreacted 11C-CO2 was removed by nitrogen. Finally, the product was neutralized with sodium phosphate and purified with sterile filtration membrane. The total synthesis time was about 10 minutes. The synthesis yield of 11C-acetate was (58.5±6.7)% (decay corrected), and the radiochemical purity was more than 99%. The residual solvents were analyzed by gas chromatography. Analysis results indicated that concentration of the acetonitrile and acetone were (0.007±0.002)% and (0.005±0.002)%, respectively. The whole synthesis process was automatically completed, and the operation was simple and flexible with high synthesis efficiency and radiochemical purity, it was suitable for clinical performance of PET.

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