Specificity of the Spectrophotometry for Detecting Aminopolyether K2.2.2 in 18F-FDG

氨基聚醚(K2.2.2)含量是18F-FDG质控中的关键指标，比较了两种常用测量K2.2.2方法的专属性。分别采用分光光度计和半定量TLC 碘显色法测量了14个样品，其中9个阴性样品、2个阳性样品和3个供试品，并与LC-MS/MS测量对比。结果显示：9个阴性样品经分光光度计法测量均为阳性，K2.2.2的测量结果在6.7～470.0 μg/mL；2个阳性样品结果偏高（53，73 μg/mL），3个供试品的K2.2.2含量在14.3~19.2 μg/mL；半定量TLC 碘显色法测量9个阴性样品结果为阴性,2个阳性样品半定量结果与实际一致,3个供试品的K2.2.2含量低于10 μg/mL;LC-MS/MS法测量的14个样品的结果与半定量TLC 碘显色法的结果一致。以上结果表明，半定量TLC 碘显色法测量K2.2.2的专属性较好，适用于测量18F-FDG溶液中K2.2.2含量。

Abstract licence: CC BY-NC-ND

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