Telomere Attrition and p53 Response 1 (TAPR1): a new player in cancer biology?

Dear editor, Telomeres are the physical ends of eukaryotic chromosomes, and their structures are essential to maintain genome stability and limit cell proliferation (). Normally, the replication of telomeric DNA is done by a molecule called telomerase, which is an enzyme that is inactive in the vast majority of somatic cells. Therefore, every time our cells go into mitosis, we lose pieces of the telomeres (). When telomeres become severely short (as a natural consequence of aging or due genotoxic [...]

Abstract licence: CC BY

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