Polymorphism of the prion protein gene (PRNP) in Polish Merino and Suffolk sheep flocks

<b>The aim of the study was to investigate the distribution of prion protein <i>PRNP</i> alleles in flocks of Polish Merino and Suffolk sheep. The research was conducted in 2012-2017 on ewes and rams kept in the Golina Wielka sheepfold (Greater Poland Voivodeship, Poland). All animals (264 ♀ and 64 ♂ Polish Merino; 98 ♀ and 73 ♂ Suffolk) were up to one year old. <i>PRNP</i> gene polymorphism was identified in the sheep. The frequency of scrapie alleles and genotypes was found to be highly significantly influenced by the breed and significantly influenced by the year in the case of Polish Merino sheep. Five alleles (ALRR, ALRQ, ALHQ, AFRQ and VLRQ) were detected in Polish Merino sheep, leading to the identification of 10 <i>PRNP</i> genotypes. In the Suffolk breed, three alleles (ALRR, ALRQ and ALHQ) and three genotypes were identified. In the Polish Merino breed, the frequency of the ALRR/ALRQ genotype was high and was the highest among all genotypes, followed by ALRR/ALRR. The level of genotypes containing valine at codon 136 was very low. In the Suffolk breed, the frequency of the ALRR/ALRR genotype was very high, and there were no alleles with valine at codon 136. In addition, in Polish Merino sheep, phenylalanine at codon 141 was detected only in the AFRQ allele, which appeared in two genotypes (in combination with ALRR and ALRQ).</b>

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