Oxidative Stress and Autophagy in Cardiac Disease, Neurological Disorders, Aging and Cancer

Abstract

Autophagy is a catalytic process of the bulk degradation of long‐lived cellular components, ultimately resulting in lysosomal digestion within mature cytoplasmic compartments known as autophagolysosomes. Autophagy serves many functions in the cell, including maintaining cellular homeostasis, a means of cell survival during stress (e.g., nutrient deprivation or starvation) or conversely as a mechanism for cell death. Increased reactive oxygen species (ROS) production and the resulting oxidative cell stress that occurs in many disease states has been shown to induce autophagy. The following review focuses on the roles that autophagy plays in response to the ROS generated in several diseases.

Cited by papers we hold 8

• An Improved System to Evaluate Superoxide‐Scavenging Effects of Bioflavonoids · 2021
  Not checked
• The Impact of Aging on Macroautophagy in the Pre-ovulatory Mouse Oocyte · 2021
  Not checked
• Sympathetic, Metabolic Adaptations, and Oxidative Stress in Autism Spectrum Disorders: How Far From Physiology? · 2018
  Not checked
• The Antioxidative Function of Alpha-Ketoglutarate and Its Applications · 2018
  No notice
• Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development · 2013
  No notice
• Inflammatory cause of metabolic syndrome via brain stress and NF-κB · 2012
  No notice
• Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions · 2012
  No notice
• 2-Deoxy-D-Glucose Treatment of Endothelial Cells Induces Autophagy by Reactive Oxygen Species-Mediated Activation of the AMP-Activated Protein Kinase · 2011
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.