Non-conventional dysplastic subtypes in inflammatory bowel disease: a review of their diagnostic characteristics and potential clinical implications

Although pathologists have a good grasp of the morphologic criteria of conventional (intestinal type) dysplasia, several unfamiliar morphologic patterns of epithelial dysplasia have been recently described in inflammatory bowel disease (IBD).They are collectively referred to as "non-conventional" dysplasia, and there are at least seven subtypes that have been reported to date.This review summarizes their morphologic criteria as well as clinicopathologic and molecular features that distinguish them from conventional dysplasia or sporadic adenomas.The review is divided into three major parts: (1) clinical importance and management of invisible/flat dysplasia, (2) potential significance of non-conventional dysplasia, and (3) subtypes of non-conventional dysplasia-(a) hypermucinous dysplasia, (b) crypt cell dysplasia, (c) dysplasia with increased Paneth cell differentiation, (d) goblet cell deficient dysplasia, and (e) serrated dysplasia, including sessile serrated lesion (SSL)-like dysplasia, traditional serrated adenoma (TSA)-like dysplasia, and serrated dysplasia, not otherwise specified (NOS). CLINICAL IMPORTANCE AND MANAGEMENT OF INVISIBLE/FLAT DYSPLASIAIBD is a well-established risk factor for the development of dysplasia and/or colorectal cancer (CRC) [1-5].The risk of CRC is similar in both ulcerative colitis (UC) and Crohn's disease [3], but younger age, male gender, longer disease duration, and primary sclerosing cholangitis (PSC) are often associated with a higher risk of developing dysplasia and/or CRC [4,[6][7][8].Surveillance colonoscopy is typically initiated at eight years after IBD diagnosis to detect pre-invasive, dysplastic lesions to reduce mortality from CRC [9][10][11][12][13].Traditionally, the detection of IBD-related dysplasia has re-Non-conventional dysplastic subtypes in inflammatory bowel disease: a review of their diagnostic characteristics and potential clinical implications

Abstract licence: CC BY-NC

40 more references, whose wording the paper’s licence keeps private.

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.