Renal involvement in children with tuberous sclerosis

Objectives: Tuberous sclerosis (TS) is a multisystemic disease with a genetic component. The central nervous system is most commonly involved. Renal involvement is also common. In this study, renal involvement was investigated descriptively and analytically in children with TS. Methods: A retrospective cohort study was performed on TS patients followed in a neurology clinic. The result variable is renal involvement. Other demographic, health-related, and family characteristics were examined as independent variables. Other system involvements in children with TS were presented analytically. Descriptive and analytical statistics were performed with SPSS 24.0 software. Results: The total number of children diagnosed with TS was 52. Renal involvement was found in 9 (17.3%) of these children. Frequency of renal involvement was not statistically increased according to independent characteristics which were obtained from patient files (demographic characteristics, presence of neurological problems in the family, weight and height percentiles, and other system involvements in children with TS). Conclusion: In our study, renal involvement was found to be less frequent than the reported in the literature. It may be more relevant to conduct studies with higher number of children with TS for risk assessment of renal involvement.

Abstract licence: CC BY-NC-SA

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