Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer
Xiangmei Wu, Lijiang Duan
Indian Journal of Pathology and Microbiology · 2025
doi:10.4103/ijpm.ijpm_277_24 (opens in a new tab)
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Abstract
Background: Investigation of a potential prognostic marker expressed in non-small cell lung cancer (NSCLC) can help patients benefit from new target therapeuticmodalities. Aims: To study the expression and correlation of P53 protein and epithelial–mesenchymal transition (EMT) related makers in NSCLC. Materials and Methods: 32 cases were selected for immunohistochemistry analysis to evaluate the expression of P53 and EMT-related makers. Results: The positive expression rate of P53 and the incidence of EMT in NSCLC were closely linked to TNM stages, differentiation degree, and lymph node metastasis ( P < 0.05). A positive association was found between P53 and EMT ( r = 0.380 , P < 0.05). Conclusions: There is a positive association between P53 , snail, and EMT. P53 may affect EMT in NSCLC by up-regulating the expression of Snail and further promoting cancer invasion and metastasis.
Abstract licence: CC BY-NC-SA
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