Effectiveness of high-flow inhalation anesthesia technique using isoflurane compared to low-flow inhalation anesthesia technique using sevoflurane and isoflurane in terms of cost and safety

Background: The low-flow technique could reduce the direct and indirect total cost as well as lower the pollution and glasshouse effects. This study aimed to compare the effectiveness of two inhalation anesthetic agents using low-flow techniques on the hemodynamic changes and cost needed. Subjects and Methods: This is an experimental study with posttest-only control group design and a cost minimization analysis on sixty patients, who had underwent surgery and met the inclusion and exclusion criteria. Patients were grouped into high-flow isoflurane (HIS), low-flow isoflurane (LIS), and low-flow sevoflurane (LSV) groups. The amount of anesthetic agent used was measured before and after the surgery. The cost needed was the main outcome of this research. Results: There was no significant difference in the hemodynamic changes between these three groups (P > 0.05). There was a significant cost difference between the three groups (P = 0.003). There was no significant cost difference between LIS and LSV groups (P = 0.353). There was a significant difference between the cost of high flow and low flow, but there was no significant difference between the cost of low-flow anesthetic agents. Conclusion: HIS resulted in a more expensive compared to the LIS and LSV. However, there was no significant cost difference between the use of low-flow techniques.

Abstract licence: CC BY-NC-SA

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