Mucoadhesive drug delivery systems

Abstract

Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Over the past few decades, mucosal drug delivery has received a great deal of attention. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive first-pass metabolism. The mucoadhesive ability of a dosage form is dependent upon a variety of factors, including the nature of the mucosal tissue and the physicochemical properties of the polymeric formulation. This review article aims to provide an overview of the various aspects of mucoadhesion, mucoadhesive materials, factors affecting mucoadhesion, evaluating methods, and finally various mucoadhesive drug delivery systems (buccal, nasal, ocular, gastro, vaginal, and rectal).

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     Not in our library10.1016/j.ijpharm.2006.09.021

113. 113.

     Salman HH, Gamazo C, Agueros M, Irache JM. Bioadhesive capacity and immunoadjuvant properties of thiamine-coated nanoparticles. Vaccine. 2007;48:8123-32.

     Not in our library10.1016/j.vaccine.2007.09.044

Cited by papers we hold 6

• Smart bioadhesives for wound healing and closure · 2023
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• Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements · 2020
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• Chitosan and its Derivatives for Ocular Delivery Formulations: Recent Advances and Developments · 2020
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• Penetration Enhancers in Ocular Drug Delivery · 2019
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• Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview · 2018
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• Ophthalmic Drug Dosage Forms: Characterisation and Research Methods · 2014
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