Lipid Rafts: Linking Alzheimer′s Amyloid‐ β Production, Aggregation, and Toxicity at Neuronal Membranes

Abstract

Lipid rafts are membrane microdomains, enriched in cholesterol and sphingolipids, into which specific subsets of proteins and lipids partition, creating cell‐signalling platforms that are vital for neuronal functions. Lipid rafts play at least three crucial roles in Alzheimer′s Disease (AD), namely, in promoting the generation of the amyloid‐ β (A β ) peptide, facilitating its aggregation upon neuronal membranes to form toxic oligomers and hosting specific neuronal receptors through which the AD‐related neurotoxicity and memory impairments of the A β oligomers are transduced. Recent evidence suggests that A β oligomers may exert their deleterious effects through binding to, and causing the aberrant clustering of, lipid raft proteins including the cellular prion protein and glutamate receptors. The formation of these pathogenic lipid raft‐based platforms may be critical for the toxic signalling mechanisms that underlie synaptic dysfunction and neuropathology in AD.

Cited by papers we hold 6

• Alzheimer’s Disease as a Membrane Disorder: Spatial Cross-Talk Among Beta-Amyloid Peptides, Nicotinic Acetylcholine Receptors and Lipid Rafts · 2019
  No notice
• Extracellular vesicle-associated Aβ mediates trans-neuronal bioenergetic and Ca2+-handling deficits in Alzheimer’s disease models · 2016
  No notice
• Amyloid-β Receptors: The Good, the Bad, and the Prion Protein · 2016
  No notice
• Ceramides in Alzheimer’s Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and A β Accumulation · 2015
  No notice
• Binding, conformational transition and dimerization of amyloid-β peptide on GM1-containing ternary membrane: insights from molecular dynamics simulation. · 2013
  Not checked
• AlzPathway: a comprehensive map of signaling pathways of Alzheimer’s disease · 2012
  No notice

Reads

A person counts once a day per paper. We keep no cookie and no address: a reader is a hash that changes every day. Any month under five reads shows no number.