GSK3 Function in the Brain during Development, Neuronal Plasticity, and Neurodegeneration

Abstract

GSK3 has diverse functions, including an important role in brain pathology. In this paper, we address the primary functions of GSK3 in development and neuroplasticity, which appear to be interrelated and to mediate age‐associated neurological diseases. Specifically, GSK3 plays a pivotal role in controlling neuronal progenitor proliferation and establishment of neuronal polarity during development, and the upstream and downstream signals modulating neuronal GSK3 function affect cytoskeletal reorganization and neuroplasticity throughout the lifespan. Modulation of GSK3 in brain areas subserving cognitive function has become a major focus for treating neuropsychiatric and neurodegenerative diseases. As a crucial node that mediates a variety of neuronal processes, GSK3 is proposed to be a therapeutic target for restoration of synaptic functioning and cognition, particularly in Alzheimer′s disease.

Cited by papers we hold 4

• Localised streptozotocin-induced structural and cognitive changes in the hippocampal cornu ammonis 1 (CA-1) neurons and mitigating effects of Zingiber officinale · 2022
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• GSK3β and Tau Protein in Alzheimer’s Disease and Epilepsy · 2020
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• Brain Insulin Resistance and Hippocampal Plasticity: Mechanisms and Biomarkers of Cognitive Decline · 2019
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• GSK3α and GSK3β Phosphorylate Arc and Regulate its Degradation · 2017
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