DNA Mismatch Repair in Eukaryotes and Bacteria

Abstract

DNA mismatch repair (MMR) corrects mismatched base pairs mainly caused by DNA replication errors. The fundamental mechanisms and proteins involved in the early reactions of MMR are highly conserved in almost all organisms ranging from bacteria to human. The significance of this repair system is also indicated by the fact that defects in MMR cause human hereditary nonpolyposis colon cancers as well as sporadic tumors. To date, 2 types of MMRs are known: the human type and Escherichia coli type. The basic features of the former system are expected to be universal among the vast majority of organisms including most bacteria. Here, I review the molecular mechanisms of eukaryotic and bacterial MMR, emphasizing on the similarities between them.

Cited by papers we hold 4

• Microsatellite instability in colorectal cancer · 2018
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• The structural impact of DNA mismatches · 2015
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• DNA Methylation and Cancer Diagnosis · 2013
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• Escherichia coli frameshift mutation rate depends on the chromosomal context but not on the GATC content near the mutation site. · 2012
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