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Thermic Cope reaction of 2-azetidinone-tethered 1,5-dienes: synthesis of tetrahydroazocinones

Pedro Almendros, Cristina Aragoncillo, Gema Cabrero and 10 more

ARKIVOC · 2009

doi:10.3998/ark.5550190.0011.308 (opens in a new tab)

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Abstract

We report herein full details of the first example of a Cope rearrangement in which the C3-C4 bond of the -lactam nucleus is the central bond of the 1,5-hexadiene system, thus providing an easy and efficient entry to novel, and in some cases optically pure functionalized azocinones.

Abstract licence: CC BY

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