血尿酸水平与非痴呆性血管性认知功能障碍的相关性研究 Association between Serum Uric Acid Level and Vascular Cognitive Impairment with No Dementia

目的 旨在探讨血尿酸水平与非痴呆性血管性认知功能障碍（vascular cognitive impairment with no dementia，VCIND）的相关性。 方法 采用病例对照研究，选取邯郸市第一医院老年科VCIND患者100例，并选取认知功能正常者 100例作为对照组，收集其基线信息、既往病史、简易精神状态量表评分等，并检测血尿酸水平。采用 t 检验计算两组尿酸水平的差异，并采用多因素Logistic回归分析探讨血尿酸水平与VCIND的相关性。 结果 V C I N D组患者血尿酸水平较认知功能正常组高[（2 6 9. 2 5±5 7.9 0）μm o l / L v s （237.19±55.25）μm ol/L]，在校正混杂因素后尿酸水平仍与VCI N D存在相关性（比值比1.100， 95%可信区间1.042～1.161）。 结论 血尿酸水平与VCIND存在相关性，这将为血管性认知功能障碍的预防提供重要依据。 Abstract: Objective To investigate the association between serum uric acid level and vascular cognitive impairment with no dementia (VCIND). Methods This was a case-control study, which enrolled 100 VCIND patients in Handan first hospital as case group and 100 matched healthy persons as control group. Clinical baseline information, medical history, mini-mental state examination (MMSE) score and serum uric level were collected. Multivariable logistic regression analysis was used to investigate the association of blood uric acid with VCIND. Results The results showed that serum uric acid level in case group was higher [(269.25±57.90) μmol/L vs (237.19±55.25) μmol/L]. After adjusting for the confounding factors, the multivariable logistic analysis showed that the association between serum uric acid level and VCIND still remained (odds ratio 1.100, 95% confidence interval 1.042-1.161). Conclusions This study demonstrated that blood uric acid level was associated with VCIND, which provided theoretical guidance for prevention of vascular cognitive impairment.

Abstract licence: CC BY-NC

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