The need to achive a multimodal therapeutical approach in glioblastoma

It is well-known that of all the brain gliomas the glioblastoma multiforme has always caused serious difficulties regarding its therapeutic solution by means of different methods. Glioblastoma multiforme is the most frequent primary brain tumor in adults. The average survival time after the establishment of the diagnosis varies between 12 and 14 months and less than 5% of the patients survive for longer than five years. Despite the progresses recorded in the identification of the complex biology of these tumors, the prognosis has not been substantially improved over the last three decades. Therefore an important attention has to be paid to the continuous review of the therapy of this disease (surgical treatment, radiotherapy and chemotherapy),a special place belonging to the administration of temozolomide, as well as the cell- and gene therapies.

Abstract licence: CC BY

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