Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai <i>Marasmius</i> sp.
Birthe Sandargo, Leon Kaysan, Rémy B. Teponno and 4 more
Beilstein Journal of Organic Chemistry · 2021
doi:10.3762/bjoc.17.97 (opens in a new tab)
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Abstract
A recent find of a <i>Marasmius</i> species in Northern Thailand led to the isolation of five unprecedented derivatives of the carotane antibiotic fulvoferruginin (<b>1</b>), fulvoferruginins B–F (<b>2</b>–<b>6</b>). The structures of these sesquiterpenoids were elucidated using HRESIMS, 1D and 2D NMR, as well as CD spectroscopy. Assessing the bioactivity, fulvoferruginin emerged as a potent cytotoxic agent of potential pharmaceutical interest.
Abstract licence: CC BY
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