Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation
Sambasivarao Kotha, Gaddamedi Sreevani, Lilya U. Dzhemileva and 3 more
Beilstein Journal of Organic Chemistry · 2019
doi:10.3762/bjoc.15.269 (opens in a new tab)
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Abstract
We report a new synthetic approach to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chemistry and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alcohol derivatives of thiazolidine-2,4-dione generated here are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562 cell lines.
Abstract licence: CC BY
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