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Total synthesis of TMG-chitotriomycin based on an automated electrochemical assembly of a disaccharide building block

Yuta Isoda, Norihiko Sasaki, Kei Kitamura and 6 more

Beilstein Journal of Organic Chemistry · 2017

doi:10.3762/bjoc.13.93 (opens in a new tab)

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Abstract

The total synthesis of TMG-chitotriomycin using an automated electrochemical synthesizer for the assembly of carbohydrate building blocks is demonstrated. We have successfully prepared a precursor of TMG-chitotriomycin, which is a structurally-pure tetrasaccharide with typical protecting groups, through the methodology of automated electrochemical solution-phase synthesis developed by us. The synthesis of structurally well-defined TMG-chitotriomycin has been accomplished in 10-steps from a disaccharide building block.

Abstract licence: CC BY

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