Multicomponent synthesis of spiropyrrolidine analogues derived from vinylindole/indazole by a 1,3-dipolar cycloaddition reaction
Manjunatha Narayanarao, Lokesh Koodlur, Vijayakumar G. Revanasiddappa and 2 more
Beilstein Journal of Organic Chemistry · 2016
doi:10.3762/bjoc.12.288 (opens in a new tab)
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Abstract
A new series of spiropyrrolidine compounds containing indole/indazole moieties as side chains have been accomplished via a one-pot multicomponent synthesis. The method uses the 1,3-dipolar cycloaddition reaction between N-alkylvinylindole/indazole and azomethine ylides, prepared in situ from cyclic/acyclic amino acids. The 1,3-dipolar cycloaddition proceeds efficiently under thermal conditions to afford the regio- and stereospecific cyclic adducts.
Abstract licence: CC BY
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