Of Mice and Men: The Coronavirus MHV and Mouse Models as a Translational Approach to Understand SARS-CoV-2

Abstract

The fatal acute respiratory coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since COVID-19 was declared a pandemic by the World Health Organization in March 2020, infection and mortality rates have been rising steadily worldwide. The lack of a vaccine, as well as preventive and therapeutic strategies, emphasize the need to develop new strategies to mitigate SARS-CoV-2 transmission and pathogenesis. Since mouse hepatitis virus (MHV), severe acute respiratory syndrome coronavirus (SARS-CoV), and SARS-CoV-2 share a common genus, lessons learnt from MHV and SARS-CoV could offer mechanistic insights into SARS-CoV-2. This review provides a comprehensive review of MHV in mice and SARS-CoV-2 in humans, thereby highlighting further translational avenues in the development of innovative strategies in controlling the detrimental course of SARS-CoV-2. Specifically, we have focused on various aspects, including host species, organotropism, transmission, clinical disease, pathogenesis, control and therapy, MHV as a model for SARS-CoV and SARS-CoV-2 as well as mouse models for infection with SARS-CoV and SARS-CoV-2. While MHV in mice and SARS-CoV-2 in humans share various similarities, there are also differences that need to be addressed when studying murine models. Translational approaches, such as humanized mouse models are pivotal in studying the clinical course and pathology observed in COVID-19 patients. Lessons from prior murine studies on coronavirus, coupled with novel murine models could offer new promising avenues for treatment of COVID-19.

References 201

1. 1.

   World Health Organization. WHO Director-General’s Opening Remarks at the Media Briefing on COVID-19—11 March 2020.

   Not in our library

2. 2.

   WHO. Coronavirus Disease (COVID-19), Situation Report-162. 2020.

   Not in our library

3. 3.

   International Committee on Taxonomy of Viruses. Virus Taxonomy: 2019 Release, EC 51.

   Not in our library

4. 4.
   Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2 · 2020

   No notice
5. 5.

   MacLachlan N.J.D.E. Coronaviridae. Fenner’s Veterinary Virology. 2017;435-461.

   Not in our library10.1016/b978-0-12-800946-8.00024-6

6. 6.

   Liu D.X., Fung T.S., Chong K.K., Shukla A., Hilgenfeld R. Accessory proteins of SARS-CoV and other coronaviruses. Antivir. Res. 2014;109:97-109.

   Not in our library10.1016/j.antiviral.2014.06.013

7. 7.

   Ji W., Wang W., Zhao X., Zai J., Li X. Cross-species transmission of the newly identified coronavirus 2019-nCoV. J. Med. Virol. 2020;92:433-440.

   Not in our library10.1002/jmv.25682

8. 8.
   On the origin and continuing evolution of SARS-CoV-2 · 2020

   Corrected
9. 9.

   Walls A.C., Park Y.J., Tortorici M.A., Wall A., McGuire A.T., Veesler D. Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell. 2020;181:281-292.e6.

   Not in our library10.1016/j.cell.2020.02.058

10. 10.

    Shang J., Ye G., Shi K., Wan Y., Luo C., Aihara H., Geng Q., Auerbach A., Li F. Structural basis of receptor recognition by SARS-CoV-2. Nature. 2020;581:221-224.

    Not in our library10.1038/s41586-020-2179-y

11. 11.

    Andersen K.G., Rambaut A., Lipkin W.I., Holmes E.C., Garry R.F. The proximal origin of SARS-CoV-2. Nat. Med. 2020;26:450-452.

    Not in our library10.1038/s41591-020-0820-9

12. 12.
    Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine · 2020

    No notice
13. 13.
    A pneumonia outbreak associated with a new coronavirus of probable bat origin · 2020

    No notice
14. 14.

    Williams R.K., Jiang G.S., Holmes K.V. Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins. Proc. Natl. Acad. Sci. USA. 1991;88:5533-5536.

    Not in our library10.1073/pnas.88.13.5533

15. 15.

    Lu H., Stratton C.W., Tang Y.W. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J. Med. Virol. 2020;92:401-402.

    Not in our library10.1002/jmv.25678

16. 16.

    Lam T.T., Jia N., Zhang Y.W., Shum M.H., Jiang J.F., Zhu H.C., Tong Y.G., Shi Y.X., Ni X.B., Liao Y.S., et al. Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins. Nature. 2020;583:282-285.

    Not in our library10.1038/s41586-020-2169-0

17. 17.

    Cheever F.S., Daniels J.B., Pappenheimer A.M., Bailey O.T. A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin. J. Exp. Med. 1949;90:181-210.

    Not in our library10.1084/jem.90.3.181

18. 18.

    MacPhee P.J., Dindzans V.J., Fung L.S., Levy G.A. Acute and chronic changes in the microcirculation of the liver in inbred strains of mice following infection with mouse hepatitis virus type 3. Hepatology. 1985;5:649-660.

    Not in our library10.1002/hep.1840050422

19. 19.

    Singh M., Khan R.S., Dine K., Das Sarma J., Shindler K.S. Intracranial Inoculation Is More Potent Than Intranasal Inoculation for Inducing Optic Neuritis in the Mouse Hepatitis Virus-Induced Model of Multiple Sclerosis. Front. Cell. Infect. Microbiol. 2018;8:311.

    Not in our library10.3389/fcimb.2018.00311

20. 20.

    Barthold S.W., Smith A.L. Mouse hepatitis virus S in weanling Swiss mice following intranasal inoculation. Lab. Anim. Sci. 1983;33:355-360.

    Not in our library

21. 21.

    Barthold S.W., Smith A.L. Mouse hepatitis virus strain—Related patterns of tissue tropism in suckling mice. Arch. Virol. 1984;81:103-112.

    Not in our library10.1007/bf01309300

22. 22.

    Barthold S.W., Smith A.L. Response of genetically susceptible and resistant mice to intranasal inoculation with mouse hepatitis virus JHM. Virus Res. 1987;7:225-239.

    Not in our library10.1016/0168-1702(87)90030-x

23. 23.

    Barthold S.W., Smith A.L. Viremic dissemination of mouse hepatitis virus-JHM following intranasal inoculation of mice. Arch. Virol. 1992;122:35-44.

    Not in our library10.1007/bf01321116

24. 24.

    Barthold S.W., Beck D.S., Smith A.L. Enterotropic coronavirus (mouse hepatitis virus) in mice: Influence of host age and strain on infection and disease. Lab. Anim. Sci. 1993;43:276-284.

    Not in our library

25. 25.

    Homberger F.R., Zhang L., Barthold S.W. Prevalence of enterotropic and polytropic mouse hepatitis virus in enzootically infected mouse colonies. Lab. Anim. Sci. 1998;48:50-54.

    Not in our library

26. 26.

    Homberger F.R. Enterotropic mouse hepatitis virus. Lab. Anim. 1997;31:97-115.

    Not in our library10.1258/002367797780600189

27. 27.

    Barthold S.W., Smith A.L., Fox J.G., Davisson M.T., Quimby F.W., Barthold S.W., Newcomer C.E., Smith A.L. Mouse Hepatitis Virus. The Mouse in Biomedical Research. 2007;Volume 2:141-178.

    Not in our library

28. 28.

    Barthold S.W., Smith A.L. Duration of mouse hepatitis virus infection: Studies in immunocompetent and chemically immunosuppressed mice. Lab. Anim. Sci. 1990;40:133-137.

    Not in our library

29. 29.

    Rehg J.E., Blackman M.A., Toth L.A. Persistent transmission of mouse hepatitis virus by transgenic mice. Comp. Med. 2001;51:369-374.

    Not in our library

30. 30.

    Barthold S.W., de Souza M.S., Smith A.L. Susceptibility of laboratory mice to intranasal and contact infection with coronaviruses of other species. Lab. Anim. Sci. 1990;40:481-485.

    Not in our library

31. 31.

    Barthold S.W., Beck D.S., Smith A.L. Mouse hepatitis virus and host determinants of vertical transmission and maternally-derived passive immunity in mice. Arch. Virol. 1988;100:171-183.

    Not in our library10.1007/bf01487681

32. 32.

    Lavi E., Gilden D.H., Highkin M.K., Weiss S.R. MHV-A59 pathogenesis in mice. Adv. Exp. Med. Biol. 1984;173:237-245.

    Not in our library10.1007/978-1-4615-9373-7_24

33. 33.

    Lavi E., Gilden D.H., Wroblewska Z., Rorke L.B., Weiss S.R. Experimental demyelination produced by the A59 strain of mouse hepatitis virus. Neurology. 1984;34:597-603.

    Not in our library10.1212/wnl.34.5.597

34. 34.

    Buchmeier M.J., Lewicki H.A., Talbot P.J., Knobler R.L. Murine hepatitis virus-4 (strain JHM)-induced neurologic disease is modulated in vivo by monoclonal antibody. Virology. 1984;132:261-270.

    Not in our library10.1016/0042-6822(84)90033-3

35. 35.

    Kyuwa S., Yamaguchi K., Toyoda Y., Fujiwara K., Hilgers J. Acute and late disease induced by murine coronavirus, strain JHM, in a series of recombinant inbred strains between BALB/cHeA and STS/A mice. Microb. Pathog. 1992;12:95-104.

    Not in our library10.1016/0882-4010(92)90112-2

36. 36.

    Barthold S.W., Smith A.L., Lord P.F., Bhatt P.N., Jacoby R.O., Main A.J. Epizootic coronaviral typhlocolitis in suckling mice. Lab. Anim. Sci. 1982;32:376-383.

    Not in our library

37. 37.

    Ding J.W., Ning Q., Liu M.F., Lai A., Leibowitz J., Peltekian K.M., Cole E.H., Fung L.S., Holloway C., Marsden P.A., et al. Fulminant hepatic failure in murine hepatitis virus strain 3 infection: Tissue-specific expression of a novel fgl2 prothrombinase. J. Virol. 1997;71:9223-9230.

    Not in our library10.1128/jvi.71.12.9223-9230.1997

38. 38.

    Piazza M. Experimental Viral Hepatitis. 1969.

    Not in our library

39. 39.

    Lucchiari M.A., Pereira C.A., Kuhn L., Lefkovits I. The pattern of proteins synthesized in the liver is profoundly modified upon infection of susceptible mice with mouse hepatitis virus 3. Res. Virol. 1992;143:231-240.

    Not in our library10.1016/s0923-2516(06)80111-1

40. 40.

    Tiensiwakul P., Husain S.S. Effect of mouse hepatitis virus infection on iron retention in the mouse liver. Br. J. Exp. Pathol. 1979;60:161-166.

    Not in our library

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