Selective Serial Multi-Antibody Biosensing with TOPAS Microstructured Polymer Optical Fibers
Lars H. Pedersen, Ole Bang, Poul E. Høiby and 1 more
Sensors · 2013
doi:10.3390/s130303242 (opens in a new tab)
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Abstract
We have developed a fluorescence-based fiber-optical biosensor, which can selectively detect different antibodies in serial at preselected positions inside a single piece of fiber. The fiber is a microstructured polymer optical fiber fabricated from TOPAS cyclic olefin copolymer, which allows for UV activation of localized sensor layers inside the holes of the fiber. Serial fluorescence-based selective sensing of Cy3-labelled α-streptavidin and Cy5-labelled α-CRP antibodies is demonstrated.
Abstract licence: CC BY
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