The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

Abstract

The neuroprotective role of phenolic acids from food has previously been reported by many authors. In this review, the role of phenolic acids in ameliorating depression, ischemia/reperfusion injury, neuroinflammation, apoptosis, glutamate-induced toxicity, epilepsy, imbalance after traumatic brain injury, hyperinsulinemia-induced memory impairment, hearing and vision disturbances, Parkinson’s disease, Huntington’s disease, anti-amyotrophic lateral sclerosis, Chagas disease and other less distributed diseases is discussed. This review covers the in vitro, ex vivo and in vivo studies concerning the prevention and treatment of neurological disorders (on the biochemical and gene expression levels) by phenolic acids.

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    Not in our library10.1007/s11064-015-1646-6

83. 83.

    Yin X., Su X.Y., Wang X.H., Su J.L., Lian Y., Zhang X.L. Effects of protocatechuic acid on expression of D2DR, iNOS, and TH in striatum and midbrain of Parkinson’s disease model mice. Chin. Trad. Herb. Drugs. 2015;46:866-870.

    Not in our library

84. 84.

    Ju D.T., Kuo W.W., Ho T.J. Protocatechuic acid from Alpinia oxyphylla induces Schwann cell migration via ERK1/2, JNK and p38 activation. Am. J. Chin. Med. 2015;43:653-665.

    Not in our library10.1142/s0192415x15500408

85. 85.

    Naghizadeh B., Mansouri M.T. Protective effects of gallic acid against streptozotocin-induced oxidative damage in rat striatum. Drug Res. 2015;65:515-520.

    Not in our library10.1055/s-0034-1377012

86. 86.

    Pemminati S. Effect of gallic acid on antioxidative enzymes activities in depression. Indian J. Psychiat. 2015;57:S125.

    Not in our library

87. 87.

    Hajimoradi M., Fazilati M., Gharib-Naseri M.K., Sarkaki A. Gallic acid and exercise training improve motor function, nerve conduction velocity but not pain sense reflex after experimental sciatic nerve crush in male rats. Avicenna J. Phytomed. 2015;5:288-297.

    Not in our library

88. 88.

    Moghadas M., Edalatmanesh M.A., Robati R. Histopathological analysis from gallic acid administration on hippocampal cell density, depression, and anxiety related behaviors in a trimethyltin intoxication model. Cell. J. 2016;17:659-667.

    Not in our library10.22074/cellj.2016.3838

89. 89.

    Oyagbemi A.A., Omobowale T.O., Saba A.B., Olowu E.R., Dada R.O., Akinrinde A.S. Gallic acid ameliorates cyclophosphamide-induced neurotoxicity in Wistar rats through free radical scavenging activity and improvement in antioxidant defense system. J. Diet. Suppl. 2016;13:402-419.

    Not in our library10.3109/19390211.2015.1103827

90. 90.

    Hsu S.S., Chou C.T., Liao W.C., Shieh P., Kuo D.H., Kuo C.C., Jan C.R., Liang W.Z. The effect of gallic acid on cytotoxicity, Ca2+ homeostasis and ROS production in DBTRG-05MG human glioblastoma cells and CTX TNA2 rat astrocytes. Chem. Biol. Interact. 2016;252:61-73.

    Not in our library10.1016/j.cbi.2016.04.010

91. 91.

    Tüzmen M.N., Yücel N.C., Kalburcu T., Demiryas N. Effects of curcumin and tannic acid on the aluminum-and lead-induced oxidative neurotoxicity and alterations in NMDA receptors. Toxicol. Mech. Method. 2015;25:120-127.

    Not in our library10.3109/15376516.2014.997947

92. 92.

    Ashafaq M., Tabassum H., Vishnoi S., Salman M., Raisuddin S., Parvez S. Tannic acid alleviates lead acetate-induced neurochemical perturbations in rat brain. Neurosci. Lett. 2016;617:94-100.

    Not in our library10.1016/j.neulet.2016.02.001

93. 93.

    Sen H.M., Ozkan A., Güven M., Akman T., Aras A.B., Sehitoglu I., Alacam H., Silan C., Cosar M., Ozisik Karaman H.I. Effects of tannic acid on the ischemic brain tissue of rats. Inflammation. 2015;38:1624-1630.

    Not in our library10.1007/s10753-015-0138-9

94. 94.

    Ashafaq M., Tabassum H., Parvez S. Modulation of behavioral deficits and neurodegeneration by tannic acid in experimental stroke challenged Wistar rats. Mol. Neurobiol. 2016.

    Not in our library10.1007/s12035-016-0096-8

95. 95.

    Ibero-Baraibar I., Perez-Cornago A., Ramirez M.J., Martinez J.A., Zulet M.A. An increase in plasma homovanillic acid with cocoa extract consumption is associated with the alleviation of depressive symptoms in overweight or obese adults on an energy restricted diet in a randomized controlled trial. J. Nutr. 2016;146:897S-904S.

    Not in our library10.3945/jn.115.222828

96. 96.

    Neider D., Lindstrom L.H., Boden R. Risk factors for suicide among patients with schizophrenia: A cohort study focused on cerebrospinal fluid levels of homovanillic acid and 5-hydroxyindoleacetic acid. Neuropsych. Dis. Treat. 2016;12:1711-1714.

    Not in our library10.2147/ndt.s107178

97. 97.

    Van de Kerkhof N.W.A., Fekkes D., van der Heijden F.M.M.A., Egger J.I.M., Verhoeven W.M.A. Relationship between plasma homovanillic acid and outcome in patients with psychosis spectrum disorders. Neuropsychobiology. 2015;71:212-217.

    Not in our library10.1159/000431095

98. 98.

    Güven M., Aras A.B., Topaloğlu N., Özkan A., Şen H.M., Kalkan Y., Okuyucu A., Akbal A., Gökmen F., Coşar M. The protective effect of syringic acid on ischemia injury in rat brain. Turk. J. Med. Sci. 2015;45:233-240.

    Not in our library10.3906/sag-1402-71

99. 99.

    Tokmak M., Yuksel Y., Sehitoglu M.H., Güven M., Akman T., Aras A.B., Cosar M., Abbed K.M. The neuroprotective effect of syringic acid on spinal cord ischemia/reperfusion injury in rats. Inflammation. 2015;38:1969-1978.

    Not in our library10.1007/s10753-015-0177-2

100. 100.

     Song M., Du Z., Lu G., Li P., Wang L. Syringic acid protects retinal ganglion cells against H2O2-induced apoptosis through the activation of Pl3K/Akt signaling pathway. Cell. Mol. Biol. 2016;62:50-54.

     Not in our library

101. 101.

     Cao Y., Zhang L., Sun S., Yi Z., Jiang X., Jia D. Neuroprotective effects of syringic acid against OGD/R-induced injury in cultured hippocampal neuronal cells. Int. J. Mol. Med. 2016;38:567-573.

     Not in our library10.3892/ijmm.2016.2623

102. 102.

     Alfredsson C.F., Ding M., Liang Q.-L., Sundstrӧm B.E., Nånberg E. Ellagic acid induces a dose-and time-dependent depolarization of mitochondria and activation of caspase-9 and -3 in human neuroblastoma cells. Biomed. Pharmacother. 2014;68:129-135.

     Not in our library10.1016/j.biopha.2013.08.010

103. 103.

     Alfredsson C.F., Rendel F., Liang Q.L., Sundstrӧm B.E., Nånberg E. Altered sensitivity to ellagic acid in neuroblastoma cells undergoing differentiation with 12-O-tetradecynoylphorbol-13-acetate and all-trans retinoic acid. Biomed. Pharmacother. 2015;76:39-45.

     Not in our library10.1016/j.biopha.2015.10.008

104. 104.
     Ellagic acid inhibits proliferation and induces apoptosis in human glioblastoma cells · 2016

     Not checked
105. 105.

     Farbood Y., Sarkaki A., Dolatshahi M., Mansouri S.M.T., Khodadadi A. Ellagic acid protects the brain against 6-hydroxydopamine induced neuroinflammation in a rat model of Parkinson’s disease. Basic Clin. Neurosci. 2015;6:15-22.

     Not in our library

106. 106.

     Khatri D., Juvekar A. Abrogation of locomotor impairment in a rotenone-induced Drosophila melanogaster and zebrafish model of Parkinson’s disease by ellagic acid and curcumin. Int. J. Nutr. Pharm. Neurol. Dis. 2016;6:90-96.

     Not in our library

107. 107.

     Mansouri M.T., Farbood Y., Naghizadeh B., Shabani S., Mirshekar M.A., Sarkaki A. Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments. Pharm. Biol. 2016;54:1947-1953.

     Not in our library10.3109/13880209.2015.1137601

108. 108.

     Liu H.P., Ren T.W., Yan W.J., Liu J., Liu R.B. Ellagic acid alleviates inflammatory pain and paclitaxel-induced neuropathic pain in murine models. Int. J. Clin. Exp. Med. 2016;9:12514-12520.

     Not in our library

109. 109.

     Chen S.Y., Zheng K., Wang Z.Q. Neuroprotective effects of ellagic acid on neonatal hypoxic brain injury via inhibition of inflammatory mediators and down-regulation of JNK/p38 MAPK activation. Trop. J. Pharm. Res. 2016;15:241-251.

     Not in our library10.4314/tjpr.v15i2.4

110. 110.

     Liu Q.S., Li S.R., Li K., Li X., Yin X., Pang Z. Ellagic acid improves endogenous neural stem cells proliferation and neurorestoration through Wnt/β-catenin signaling in vivo and in vitro. Mol. Nutr. Food Res. 2017;61.

     Not in our library10.1002/mnfr.201600587

111. 111.

     Herrmann K. Occurrence and content of hydroxycinnamic and hydroxybenzoic acid compounds in foods. Crit. Rev. Sci. Food Nutr. 1989;28:315-347.

     Not in our library10.1080/10408398909527504

112. 112.

     Scalbert A., Williamson G. Dietary intake and bioavailability of polyphenols. J. Nutr. 2000;130:2073S-2085S.

     Not in our library10.1093/jn/130.8.2073s

113. 113.

     Bourne L.C., Rice-Evans C. Bioavailablility of ferulic acid. Biochem. Biophys. Res. Commun. 1998;253:222-227.

     Not in our library10.1006/bbrc.1998.9681

114. 114.

     Zamora-Ros R., Knaze V., Rothwell J.A., Hémon B., Moskal A., Overvad K., Tjønneland A., Kyrø C., Fagherazzi G., Boutron-Ruault M.C., et al. Dietary polyphenol intake in Europe: The European prospective investigation into cancer and nutrition (EPIC) study. Eur. J. Nutr. 2016;55:1359-1375.

     Not in our library10.1007/s00394-015-0950-x

115. 115.

     Tresserra-Rimbau A., Medina-Remón A., Pérez-Jiménez J., Martínez-González M.A., Covas M.I., Corella D., Salas-Salvadó J., Gómez-Gracia E., Lapetra J., Arós F., et al. Dietary intake and major food sources of polyphenols in a Spanish population at high cardiovascular risk: The PREDIMED study. Nutr. Metab. Cardiovasc. Dis. 2013;23:953-959.

     Not in our library10.1016/j.numecd.2012.10.008

116. 116.
     Estimated dietary intake and major food sources of polyphenols in the Polish arm of the HAPIEE study · 2014

     No notice
117. 117.

     Ferruzzi M.G., Lobo J.K., Janle E.M., Cooper B., Simon J.E., Wu Q.L., Welch C., Ho L., Weaver C., Pasinetti G.M. Bioavailability of gallic acid and catechins from grape seed polyphenol extract is improved by repeated dosing in rats: implications for treatment in Alzheimer’s disease. J. Alzheimers Dis. 2009;18:113-124.

     Not in our library10.3233/jad-2009-1135

118. 118.

     Zhang Y.J., Wu L., Zhang Q.L., Li J., Yin F.X., Yuan Y. Pharmacokinetics of phenolic compounds of Danshen extract in rat blood and brain by microdialysis sampling. J. Ethnopharmacol. 2011;136:129-136.

     Not in our library10.1016/j.jep.2011.04.023

119. 119.

     Margalef M., Pons Z., Bravo F.I., Muguerza B., Arola-Arnal A. Tissue distribution of rat flavanol metabolites at different doses. J. Nutr. Biochem. 2015;26:987-995.

     Not in our library10.1016/j.jnutbio.2015.04.006

120. 120.

     Del Bo C., Ciapellano S., Klimis-Zacas D., Martini D., Gardana C., Riso P., Porrini M. Anthocyanin absorption, metabolism, and distribution from a wild blueberry-enriched diet (Vaccinium angustifolium) is affected by diet duration in the Sprague-Dawley rat. J. Agric. Food Chem. 2010;58:2491-2497.

     Not in our library10.1021/jf903472x

121. 121.

     Wang D., Ho L., Faith J., Ono K., Janle E.M., Lachcik P.J., Cooper B.R., Jannasch A.H., D’Arcy B.R., Williams B.A., et al. Role of intestinal microbiota in the generation of polyphenol derived phenolic acid mediated attenuation of Alzheimer’s disease β-amyloid oligomerization. Mol. Nutr. Food. Res. 2015;59:1025-1040.

     Not in our library10.1002/mnfr.201400544

122. 122.

     Chang M.X., Xu L.Y., Tao J.S., Feng Y. Metabolism and pharmacokinetics of ferulic acid in rats. China J. Chin. Mater. Medica. 1993;18:300-2319.

     Not in our library

123. 123.

     Wu K., Wang Z.Z., Liu D., Qi X.R. Pharmacokinetics, brain distribution, release and blood-brain barrier transport of Shunaoxin pills. J. Ethnopharmacol. 2014;151:1133-1140.

     Not in our library10.1016/j.jep.2013.12.027

124. 124.

     Pinheiro Fernandes F.D., Fontenele Menezes A.P., de Sousa Neves J.C., Fonteles A.A., da Silva A.T., de Araújo R.P., Santos do Carmo M.R., de Souza C.M., de Andrade G.M. Caffeic acid protects mice from memory deficits induced by focal cerebral ischemia. Behav. Pharmacol. 2014;25:637-647.

     Not in our library10.1097/fbp.0000000000000076

125. 125.

     Ritschel W.A., Starzacher A., Sabouni A., Hussain A.S., Koch H.P. Percutaneous absorption of rosmarinic acid in the rat. Method. Find. Exp. Clin. Pharmacol. 1989;11:345-352.

     Not in our library

126. 126.

     Yan J.J., Cho J.Y., Kim H.S., Kim K.L., Jung J.S., Huh S.O., Suh H.W., Kim Y.H., Song D.K. Protection against b-amyloid peptide toxicity in vivo with long-term administration of ferulic acid. Br. J. Pharmacol. 2001;133:89-96.

     Not in our library10.1038/sj.bjp.0704047

127. 127.

     Zhao J., Pati S., Redell J.B., Zhang M., Moore A.N., Dash P.K. Caffeic acid phenethyl ester protects blood-brain barrier integrity and reduces contusion volume in rodent models of traumatic brain injury. J. Neurotraum. 2012;29:1209-1218.

     Not in our library10.1089/neu.2011.1858

128. 128.

     Vauzour D., Vafeiadou K., Corona G., Pollard S.E., Tzounis X., Spencer J.P. Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury. J. Agric. Food Chem. 2007;55:2854-2860.

     Not in our library10.1021/jf063304z

129. 129.

     Luan H., Kan Z., Xu Y., Lv C., Jiang W. Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response. J. Neuroinflamm. 2013;10.

     Not in our library10.1186/1742-2094-10-28

130. 130.

     Tarozzi A., Morroni F., Hrelia S., Angeloni C., Marchesi A., Cantelli-Forti G., Hrelia P. Neuroprotective effects of anthocyanins and their in vivo metabolites in SH-SY5Y cells. Neurosci. Lett. 2007;424:36-40.

     Not in our library10.1016/j.neulet.2007.07.017

131. 131.

     Scapagnini G., Foresti R., Calabrese V., Giuffrida Stella A.M., Green C.J., Motterlini R. Caffeic acid phenethyl ester and curcumin: A novel class of heme oxygenase-1 inducers. Mol. Pharmacol. 2002;3:554-561.

     Not in our library10.1124/mol.61.3.554

132. 132.

     Scapagnini G., Butterfield D.A., Colombrita C., Sultana R., Pascale A., Calabrese V. Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress. Antioxid. Redox Signal. 2004;6:811-818.

     Not in our library10.1089/ars.2004.6.811

Cited by papers we hold 7

• Polyphenols and Their Impact on the Prevention of Neurodegenerative Diseases and Development · 2023
  No notice
• Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia · 2022
  No notice
• Phenolic Acids and Prevention of Cognitive Decline: Polyphenols with a Neuroprotective Role in Cognitive Disorders and Alzheimer’s Disease · 2022
  No notice
• Trichoderma reesei fungal degradation boosted the potentiality of date pit extract in fighting scopolamine-induced neurotoxicity in male rats · 2021
  Not checked
• Polyphenols from Food and Natural Products: Neuroprotection and Safety · 2020
  No notice
• Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis · 2019
  No notice
• The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials · 2018
  No notice

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