Solubility and Bioavailability Enhancement of Oridonin: A Review
Yuanyuan Zhang, Shaohua Wang, Mengmeng Dai and 3 more
Molecules · 2020
doi:10.3390/molecules25020332 (opens in a new tab)
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Abstract
Oridonin (ORI), an ent-kaurene tetracyclic diterpenoid compound, is isolated from Chinese herb <i>Rabdosia rubescens</i> with various biological and pharmacological activities including anti-tumor, anti-microbial and anti-inflammatory effects. However, the clinical application of ORI is limited due to its low solubility and poor bioavailability. In order to overcome these shortcomings, many strategies have been explored such as structural modification, new dosage form, etc. This review provides a detailed discussion on the research progress to increase the solubility and bioavailability of ORI.
Abstract licence: CC BY
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