Fractionated Antioxidant and Anti-inflammatory Kernel Oil from Torreya fargesii

Polymethylene-interrupted polyunsaturated fatty acids (PMI-PUFAs) are emerging functional lipids with proven antioxidant and anti-inflammatory effects. In this study, a typical PMI-PUFA, sciadonic acid (C20:3, 5c 11c 14c), was enriched in the kernel oil of <i>Torreya fargesii</i> (<i>T. fargesii</i>) by fractionation. Fractionated kernel oil of <i>T. fargesii</i> (containing 25% sciadonic acid) showed equal stability and similar radical scavenging ability compared with the non-fractionated oil. In anti-inflammatory tests, fractionated kernel oil was shown to inhibit the activity of phosphodiesterase (PDE-5, efficiency 80% at 133.7 &#956;g/mL) and lipoxygenase-5 (LOX-5, efficiency 65% at 66.7 &#956;g/mL) more effectively than the non-fractionated oil. This shows that increasing the amount of sciadonic acid can enhance the anti-inflammatory effect of the kernel oil. This research also indicates that fractionation is a feasible way to obtain sciadonic acid&#8722;rich functional oil with potential pharmacological effects.

Abstract licence: CC BY

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