Investigation of the Anticancer Activity of Coordination-Driven Self-AssembledTwo-Dimensional Ruthenium Metalla-Rectangle

Coordination-driven self-assembly is an effective synthetic tool for the construction of spatially and electronically tunable supramolecular coordination complexes (SCCs), which are useful in various applications. Herein, we report the synthesis of a two-dimensional discrete metalla-rectangle [(<i>&#951;</i>⁶-<i>p</i>-cymene)₄Ru₄(C₆H₂O₄)₂(<b>2</b>)₂](CF₃SO₃)₄ (<b>3</b>) by the reaction of a dinuclear half-sandwich ruthenium (II) complex [Ru₂(<i>&#951;</i>⁶-<i>p</i>-cymene)₂(C₆H₂O₄)Cl₂] (<b>1</b>) and bis-pyridyl amide linker (<b>2</b>) in the presence of AgO₃SCF₃. This cationic ruthenium metalla-rectangle (<b>3</b>) has been isolated as its triflate salt and characterized by analytical techniques including elemental analysis, Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy (¹H-NMR), carbon nuclear magnetic resonance spectroscopy (¹³C-NMR), ¹H-¹H correlation spectroscopy (COSY), ¹H-¹H nuclear Overhauser effect spectroscopy (NOESY), diffusion ordered spectroscopy (DOSY), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS). Significantly, the 2D cationic ruthenium metalla-rectangle showed better anticancer activity towards three different cell lines (A549, Caki-1 and Lovo) as compared with the parent ruthenium complex (<b>1</b>) and the commercially used drug, cisplatin.

Abstract licence: CC BY

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