New γ -Halo- δ -lactones and δ -Hydroxy- γ -lactones with Strong Cytotoxic Activity
Angelika Kamizela, Barbara Gawdzik, Mariusz Urbaniak and 5 more
Molecules · 2019
doi:10.3390/molecules24101875 (opens in a new tab)
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Abstract
This paper presents the synthesis of γ -halo- δ -lactones, δ -iodo- γ -lactones and δ -hydroxy- γ -lactones from readily available organic substrates such as trans-crotonaldehyde and aryl bromides. Crystal structure analysis was carried out for lactones that were obtained in crystalline form. All halo- δ -lactones and δ -hydroxy- γ -lactones were highly cytotoxic against gastric cancer AGS cells with I C 50 values in the range of 0.0006–0.0044 mM. Some lactones showed high bactericidal activity against E. coli ATCC 8739 and S. aureus ATCC 65389, which reduced the number of CFU/mL by 70–83% and 87% respectively.
Abstract licence: CC BY
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